Optic nerve glioma epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

Optic nerve gliomas affects females and males equally. Optic nerve gliomas commonly affects individuals younger than twenty years of age. There is no racial predilection to the optic nerve glioma.[1]

Epidemiology and Demographics

  • Optic nerve gliomas typically present in children, and often in the setting of NF1 (10-63%).
  • In adults, optic nerve gliomas do occur but are very rare and usually aggressive tumors. In such cases no association with NF1 has been found.[2]
  • Five percentage (5%) of all childhood brain tumors account for optic nerve gliomas. About 1% of all intracranial tumors are comprised of optic-nerve gliomas.[3] It is most common in children who have the genetic condition neurofibromatosis 1 (NF1).

Incidence

The incidence of NF-1 among patients of optic nerve glioma is 10-70% and the incidence of optic nerve glioma in patients with NF-1 varies from 8% to 31%.[4]

Gender

Males and females are equally affected.

Age

The mean age of presentation of optic nerve glioma is 8.8 years.[5] The majority of optic nerve gliomas occur in children. They are usually slow-growing and noncancerous and almost always occur before age 20.[2]

Age of onset of optic nerve glioma Percentage of optic nerve glioma diagnosed
Before the age 18 months

25%

Before the age of 5

50%

Before the age of 10

75%

Before the age of 20

90%

Race

There is no racial predilection to the development of optic nerve glioma.

References

  1. Optic nerve glioma. Radiopedia(2015) http://radiopaedia.org/articles/optic-nerve-glioma Accessed on October 2 2015
  2. 2.0 2.1 Optic glioma. Medline Plus(2015) https://www.nlm.nih.gov/medlineplus/ency/article/001024.htm Accessed on October 5 2015
  3. Dutton JJ (1994). "Gliomas of the anterior visual pathway". Surv Ophthalmol. 38 (5): 427–52. PMID 8009427.
  4. Nair AG, Pathak RS, Iyer VR, Gandhi RA (2014). [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi? dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24736941 "Optic nerve glioma: an update"] Check |url= value (help). Int Ophthalmol. 34 (4): 999–1005. doi:10.1007/s10792-014-9942-8. PMID 24736941. line feed character in |url= at position 54 (help)
  5. Alvord EC, Lofton S (1988). "Gliomas of the optic nerve or chiasm. Outcome by patients' age, tumor site, and treatment". J Neurosurg. 68 (1): 85–98. doi:10.3171/jns.1988.68.1.0085. PMID 3275755.

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