Non-alcoholic fatty liver disease laboratory findings: Difference between revisions
Jump to navigation
Jump to search
Aditya Ganti (talk | contribs) |
Aditya Ganti (talk | contribs) No edit summary |
||
| Line 3: | Line 3: | ||
{{CMG}}; {{AE}} {{VKG}} | {{CMG}}; {{AE}} {{VKG}} | ||
==Overview== | ==Overview== | ||
There are no | There are no specific diagnostic laboratory findings associated with non alcoholic fatty liver disease. Laboratory findings include abnormal liver function tests but are unspecific. Other laboratory tests are generally performed to rule out other diagnosis. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
*There is no | *There is no specific laboratory findings diagnostic for non alcoholic fatty liver disease.<ref name="urlNonalcoholic fatty liver disease: Indications for liver biopsy and noninvasive biomarkers - Noureddin - 2012 - Clinical Liver Disease - Wiley Online Library">{{cite web |url=http://onlinelibrary.wiley.com/doi/10.1002/cld.65/pdf |title=Nonalcoholic fatty liver disease: Indications for liver biopsy and noninvasive biomarkers - Noureddin - 2012 - Clinical Liver Disease - Wiley Online Library |format= |work= |accessdate=}}</ref><ref name="urlNonalcoholic fatty liver disease (NAFLD), including nonalcoholic steatohepatitis (NASH)">{{cite web |url=https://www.uptodate.com/contents/nonalcoholic-fatty-liver-disease-nafld-including-nonalcoholic-steatohepatitis-nash-beyond-the-basics |title=Nonalcoholic fatty liver disease (NAFLD), including nonalcoholic steatohepatitis (NASH) |format= |work= |accessdate=}}</ref> | ||
*Liver function tests | |||
**Typical finding include a 2-4 fold elevation of the [[ALT]] | |||
**An [[ALT]]/[[AST]] ratio of greater than 1. | |||
* | * Evaluation for alternative causes of liver disease should be performed. | ||
** These include [[HCV|HCV serology]] , serologies for [[autoimmune hepatitis]], and copper studies including serum [[ceruloplasmin]] and 24-hour urinary copper if [[Wilson's disease|Wilson disease]] is suspected. | |||
* [[Fasting plasma glucose]] testing following an overnight fast is important to look for [[hyperglycemia]], which is an indicator of [[insulin resistance]]. | |||
* | ** Fasting [[insulin]] levels can confirm [[hyperinsulinemia]] and [[insulin resistance]] | ||
* [[Lipid]] levels ( serum [[cholesterol]] and fasting [[triglycerides]] ) should be evaluated | |||
** [[Dyslipidemia]], beside being a very common finding in NAFLD, is a risk factor that can be modified by dietary and/or pharmacologic intervention. | |||
* [[ | * Iron studies (in particular elevated [[ferritin]] and transferring saturation) are often abnormal in NAFLD | ||
* | * Some patients with NAFLD may have low titers of [[Autoimmune disease|autoimmune]] [[antibodies]]. | ||
* | * [[Biomarkers]] | ||
* | ** CK18 represents a promising [[biomarker]] for evaluation of the presence of NASH. | ||
** A defining characteristic of NASH is [[cellular]] death, and [[serum]] CK18 levels had been shown to correlate with [[steatohepatitis]]. | |||
CK18 represents a promising [[biomarker]] for evaluation of the presence of NASH. A defining characteristic of NASH is [[cellular]] death, and [[serum]] CK18 levels had been shown to correlate with [[steatohepatitis]] | |||
==References== | ==References== | ||
Revision as of 19:08, 22 December 2017
|
Non-Alcoholic Fatty Liver Disease Microchapters |
|
Differentiating Non-Alcoholic Fatty Liver Disease from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case studies |
|
Non-alcoholic fatty liver disease laboratory findings On the Web |
|
American Roentgen Ray Society Images of Non-alcoholic fatty liver disease laboratory findings |
|
FDA on Non-alcoholic fatty liver disease laboratory findings |
|
CDC on Non-alcoholic fatty liver disease laboratory findings |
|
Non-alcoholic fatty liver disease laboratory findings in the news |
|
Blogs on Non-alcoholic fatty liver disease laboratory findings |
|
Directions to Hospitals Treating Non-alcoholic fatty liver disease |
|
Risk calculators and risk factors for Non-alcoholic fatty liver disease laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Overview
There are no specific diagnostic laboratory findings associated with non alcoholic fatty liver disease. Laboratory findings include abnormal liver function tests but are unspecific. Other laboratory tests are generally performed to rule out other diagnosis.
Laboratory Findings
- There is no specific laboratory findings diagnostic for non alcoholic fatty liver disease.[1][2]
- Liver function tests
- Evaluation for alternative causes of liver disease should be performed.
- These include HCV serology , serologies for autoimmune hepatitis, and copper studies including serum ceruloplasmin and 24-hour urinary copper if Wilson disease is suspected.
- Fasting plasma glucose testing following an overnight fast is important to look for hyperglycemia, which is an indicator of insulin resistance.
- Fasting insulin levels can confirm hyperinsulinemia and insulin resistance
- Lipid levels ( serum cholesterol and fasting triglycerides ) should be evaluated
- Dyslipidemia, beside being a very common finding in NAFLD, is a risk factor that can be modified by dietary and/or pharmacologic intervention.
- Iron studies (in particular elevated ferritin and transferring saturation) are often abnormal in NAFLD
- Some patients with NAFLD may have low titers of autoimmune antibodies.
- Biomarkers
- CK18 represents a promising biomarker for evaluation of the presence of NASH.
- A defining characteristic of NASH is cellular death, and serum CK18 levels had been shown to correlate with steatohepatitis.