Neurofibroma: Difference between revisions
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{{ | {{Neurofibroma}} | ||
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==[[Neurofibroma overview|Overview]]== | |||
==[[Neurofibroma historical perspective|Historical Perspective]]== | |||
==[[Neurofibroma classification|Classification]]== | |||
==[[Neurofibroma pathophysiology|Pathophysiology]]== | |||
==[[Neurofibroma causes|Causes]]== | |||
==[[Neurofibroma differential diagnosis|Differentiating Neurofibroma]]== | |||
==[[Neurofibroma epidemiology and demographics|Epidemiology and Demographics]]== | |||
==[[Neurofibroma risk factors|Risk Factors]]== | |||
==[[Neurofibroma screening|Screening]]== | |||
==[[Neurofibroma natural history, complications and prognosis|Natural History, Complications and Prognosis]]== | |||
==Diagnosis== | |||
[[Neurofibroma staging|Staging]] | [[Neurofibroma history and symptoms|History and Symptoms]] | [[Neurofibroma physical examination|Physical Examination]] | [[Neurofibroma laboratory findings|Laboratory Findings]] | [[Neurofibroma x ray|X Ray]] | [[Neurofibroma CT|CT]] | [[Neurofibroma MRI|MRI]] [[Neurofibroma ultrasound|Ultrasound]] | [[Neurofibroma other imaging findings|Other Imaging Findings]] | [[Neurofibroma other diagnostic studies|Other Diagnostic Studies]] | [[Neurofibroma biopsy|Biopsy]] | |||
==Treatment== | |||
[[Neurofibroma medical therapy|Medical therapy]] | [[Neurofibroma surgery|Surgery]] | [[Neurofibroma primary prevention|Primary prevention]] | [[Neurofibroma secondary prevention|Secondary prevention]] | [[Neurofibroma cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Neurofibroma future or investigational therapies|Future or Investigational Therapies]] | |||
==Case Studies== | |||
[[Neurofibroma case study one|Case #1]] | |||
==Overview== | ==Overview== | ||
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[[category:Dermatology]] | [[category:Dermatology]] | ||
[[Category:Oncology]] | [[Category:Oncology]] | ||
{{Nervous tissue tumors}} | {{Nervous tissue tumors}} | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
Revision as of 13:51, 12 November 2015
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Neurofibroma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Neurofibroma On the Web |
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American Roentgen Ray Society Images of Neurofibroma |
For patient information click here
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2] Shanshan Cen, M.D. [3]
Synonyms and keywords:
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Neurofibroma
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Staging | History and Symptoms | Physical Examination | Laboratory Findings | X Ray | CT | MRI Ultrasound | Other Imaging Findings | Other Diagnostic Studies | Biopsy
Treatment
Medical therapy | Surgery | Primary prevention | Secondary prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies
Case Studies
Overview
Neurofibroma is a type of nerve sheath tumor. In contrast to schwannomas - another type of tumor arising from the Schwann cells - neurofibromas incorporate all sorts of cells and structural elements in addition to the Schwann cells.[1]
Pathophysiology
Neurofibromas infiltrate the nerve and splay apart the individual nerve fibers. Although usually benign, Neurofibromas can sometimes degenerate into cancer.
Single neurofibromas often occur in middle and old age and grow at the margins of the peripheral nerves, displacing the nerve's main body.
The vestibulocochlear (acoustic) nerve is the most commonly affected, (see acoustic neuroma). Other cranial nerves and spinal nerves are less commonly involved.
Diagnosis
Physical Examination
Skin
Trunk
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![Neurofibroma. With permission from Dermatology Atlas.[2]](/images/1/12/Neurofibroma01.jpg)
Neurofibroma. With permission from Dermatology Atlas.[2]
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![Neurofibroma. With permission from Dermatology Atlas.[2]](/images/3/3b/Neurofibroma02.jpg)
Neurofibroma. With permission from Dermatology Atlas.[2]
![Neurofibroma. With permission from Dermatology Atlas.[2]](/index.php/File:Neurofibroma01.jpg)
![Neurofibroma. With permission from Dermatology Atlas.[2]](/index.php/File:Neurofibroma02.jpg)
Treatment
Surgical resection is curative, although tumors are not easily removable if they surround important nerves such as the optic nerve. There is a risk of functional damage due to interference with the nerve. Debulking may be helpful.[3]
References
- ↑ Miller RT. Immunohistochemistry in the differential diagnosis of schwannoma and neurofibroma. Propath 2004 Oct. http://www.ihcworld.com/_newsletter/2004/2004-10_NF_vs_schwannoma_v1.pdf
- ↑ 2.0 2.1 "Dermatology Atlas".
- ↑ Babovic S, Bite U, Karnes PS, Babovic-Vuksanovic D (2003). "Liposuction: a less invasive surgical method of debulking plexiform neurofibromas". Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 29 (7): 785–7. PMID 12828709.