Neuroblastoma history and symptoms: Difference between revisions
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==Overview== | ==Overview== | ||
A detailed history of presenting [[symptoms]], [[family history]] and other associated [[Symptom|symptoms]] should be undertaken when evaluating a [[patient]] of neuroblastoma. General neuroblastoma symptoms include; [[fever]], [[irritability]], [[fatigue]], [[loss of appetite]] and [[weight loss]]. Other [[symptoms]] depending upon the [[anatomical]] location of neuroblastoma include [[abdominal pain]], [[distension]] and [[constipation]] ([[abdomen]]), [[Dyspnea|shortness of breath]], [[chronic cough]] & [[difficulty swallowing]] ([[posterior mediastinum]]), [[weakness]], [[numbness]], [[paralysis]] ([[retroperitoneum]]), visual defects, facial bruising ([[Head and neck anatomy|head & neck]]) and [[pallor]], [[bone pain]] ([[bone marrow]] [[Metastasis|metastases]]). | |||
==History== | ==History== | ||
* A detailed history of presenting symptoms (duration, onset, progression), a thorough family history and a review of other other associated symptoms should be undertaken when evaluating a patient of neuroblastoma. When obtaining the history focus on possible associated syndromes as well, such as:<ref>{{Cite journal | * A detailed history of presenting [[symptoms]] (duration, onset, progression), a thorough [[family history]] and a review of other other associated [[symptoms]] should be undertaken when evaluating a [[patient]] of neuroblastoma. When obtaining the history focus on possible associated [[Syndrome|syndromes]] as well, such as:<ref>{{Cite journal | ||
| author = [[Sidharth Mahapatra]] & [[Kishore B.. Challagundla]] | | author = [[Sidharth Mahapatra]] & [[Kishore B.. Challagundla]] | ||
| title = Cancer, Neuroblastoma | | title = Cancer, Neuroblastoma | ||
| Line 13: | Line 13: | ||
| month = January | | month = January | ||
| pmid = 28846355 | | pmid = 28846355 | ||
}}</ref><ref>{{Cite journal | |||
| author = [[John M. Maris]] | |||
| title = Recent advances in neuroblastoma | |||
| journal = [[The New England journal of medicine]] | |||
| volume = 362 | |||
| issue = 23 | |||
| pages = 2202–2211 | |||
| year = 2010 | |||
| month = June | |||
| doi = 10.1056/NEJMra0804577 | |||
| pmid = 20558371 | |||
}}</ref> | }}</ref> | ||
:* [[Neurofibromatosis type 1]] ([[von Recklinghausen disease]]) | :* [[Neurofibromatosis type 1]] ([[von Recklinghausen disease]]) | ||
| Line 22: | Line 33: | ||
==Symptoms== | ==Symptoms== | ||
* General symptoms of neuroblastoma include:<ref>{{Cite journal | * General [[symptoms]] of neuroblastoma include:<ref>{{Cite journal | ||
| author = [[J. W. Duckett]] & [[C. E. Koop]] | | author = [[J. W. Duckett]] & [[C. E. Koop]] | ||
| title = Neuroblastoma | | title = Neuroblastoma | ||
| Line 32: | Line 43: | ||
| month = June | | month = June | ||
| pmid = 331618 | | pmid = 331618 | ||
}}</ref><ref>{{Cite journal | |||
| author = [[Nadja C. Colon]] & [[Dai H. Chung]] | |||
| title = Neuroblastoma | |||
| journal = [[Advances in pediatrics]] | |||
| volume = 58 | |||
| issue = 1 | |||
| pages = 297–311 | |||
| year = 2011 | |||
| month = | |||
| doi = 10.1016/j.yapd.2011.03.011 | |||
| pmid = 21736987 | |||
}}</ref> | }}</ref> | ||
:* [[Fever]] | :* [[Fever]] | ||
| Line 39: | Line 61: | ||
:* [[Weight loss]] | :* [[Weight loss]] | ||
* However, the specific clinical presentation of neuroblastoma is determined by the exact anatomical location of the tumor such as:<ref name="O"> Neuroblastoma Childhood: Symptoms and Signs. Cancer.net http://www.cancer.net/cancer-types/neuroblastoma-childhood/symptoms-and-signs Accessed on October, 7 2015</ref><ref name="pmid21736987">{{cite journal| author=Colon NC, Chung DH| title=Neuroblastoma. | journal=Adv Pediatr | year= 2011 | volume= 58 | issue= 1 | pages= 297-311 | pmid=21736987 | doi=10.1016/j.yapd.2011.03.011 | pmc=PMC3668791 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21736987 }} </ref> | * However, the specific clinical presentation of neuroblastoma is determined by the exact [[anatomical]] location of the [[tumor]] such as:<ref name="O">Neuroblastoma Childhood: Symptoms and Signs. Cancer.net http://www.cancer.net/cancer-types/neuroblastoma-childhood/symptoms-and-signs Accessed on October, 7 2015</ref><ref name="pmid21736987">{{cite journal| author=Colon NC, Chung DH| title=Neuroblastoma. | journal=Adv Pediatr | year= 2011 | volume= 58 | issue= 1 | pages= 297-311 | pmid=21736987 | doi=10.1016/j.yapd.2011.03.011 | pmc=PMC3668791 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21736987 }} </ref><ref>{{Cite journal | ||
| author = [[Titilope A. Ishola]] & [[Dai H. Chung]] | |||
| title = Neuroblastoma | |||
| journal = [[Surgical oncology]] | |||
| volume = 16 | |||
| issue = 3 | |||
| pages = 149–156 | |||
| year = 2007 | |||
| month = November | |||
| doi = 10.1016/j.suronc.2007.09.005 | |||
| pmid = 17976976 | |||
}}</ref> | |||
:* '''Abdominal neuroblastoma symptoms:''' | :* '''Abdominal neuroblastoma symptoms:''' | ||
| Line 48: | Line 81: | ||
:* '''Posterior mediastinum neuroblastoma symptoms:''' | :* '''Posterior mediastinum neuroblastoma symptoms:''' | ||
::* [[Shortness of breath]] | ::* [[Shortness of breath]] | ||
::* | ::* [[Chronic cough]] | ||
::* Difficulty swallowing | ::* [[Difficulty swallowing]] | ||
::* Difficulty breathing | ::* [[Difficulty breathing]] | ||
:* '''Retroperitoneal neuroblastoma symptoms:''' | :* '''Retroperitoneal neuroblastoma symptoms:''' | ||
Latest revision as of 15:19, 6 March 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD[2]Haytham Allaham, M.D. [3]
Overview
A detailed history of presenting symptoms, family history and other associated symptoms should be undertaken when evaluating a patient of neuroblastoma. General neuroblastoma symptoms include; fever, irritability, fatigue, loss of appetite and weight loss. Other symptoms depending upon the anatomical location of neuroblastoma include abdominal pain, distension and constipation (abdomen), shortness of breath, chronic cough & difficulty swallowing (posterior mediastinum), weakness, numbness, paralysis (retroperitoneum), visual defects, facial bruising (head & neck) and pallor, bone pain (bone marrow metastases).
History
- A detailed history of presenting symptoms (duration, onset, progression), a thorough family history and a review of other other associated symptoms should be undertaken when evaluating a patient of neuroblastoma. When obtaining the history focus on possible associated syndromes as well, such as:[1][2]
Symptoms
- However, the specific clinical presentation of neuroblastoma is determined by the exact anatomical location of the tumor such as:[5][6][7]
- Abdominal neuroblastoma symptoms:
- Posterior mediastinum neuroblastoma symptoms:
References
- ↑ Sidharth Mahapatra & Kishore B.. Challagundla (2018). "Cancer, Neuroblastoma". PMID 28846355. Unknown parameter
|month=ignored (help) - ↑ John M. Maris (2010). "Recent advances in neuroblastoma". The New England journal of medicine. 362 (23): 2202–2211. doi:10.1056/NEJMra0804577. PMID 20558371. Unknown parameter
|month=ignored (help) - ↑ J. W. Duckett & C. E. Koop (1977). "Neuroblastoma". The Urologic clinics of North America. 4 (2): 285–295. PMID 331618. Unknown parameter
|month=ignored (help) - ↑ Nadja C. Colon & Dai H. Chung (2011). "Neuroblastoma". Advances in pediatrics. 58 (1): 297–311. doi:10.1016/j.yapd.2011.03.011. PMID 21736987.
- ↑ Neuroblastoma Childhood: Symptoms and Signs. Cancer.net http://www.cancer.net/cancer-types/neuroblastoma-childhood/symptoms-and-signs Accessed on October, 7 2015
- ↑ Colon NC, Chung DH (2011). "Neuroblastoma". Adv Pediatr. 58 (1): 297–311. doi:10.1016/j.yapd.2011.03.011. PMC 3668791. PMID 21736987.
- ↑ Titilope A. Ishola & Dai H. Chung (2007). "Neuroblastoma". Surgical oncology. 16 (3): 149–156. doi:10.1016/j.suronc.2007.09.005. PMID 17976976. Unknown parameter
|month=ignored (help)