Neuroblastoma history and symptoms: Difference between revisions

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__NOTOC__
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{{Neuroblastoma}}
{{Neuroblastoma}}
{{CMG}} {{AE}}{{HL}}
{{CMG}} {{AE}}{{ZAS}}{{HL}}


==Overview==
==Overview==
Symptoms of neuroblastoma include fever, abdominal distension, constipation, cough, and weakness.<ref name="wiki"> Neuroblastoma. Wikipedia (2015) https://en.wikipedia.org/wiki/Neuroblastoma Accessed on October, 7 2015</ref><ref name="O"> Neuroblastoma Childhood: Symptoms and Signs. Cancer.net http://www.cancer.net/cancer-types/neuroblastoma-childhood/symptoms-and-signs Accessed on October, 7 2015</ref><ref name="pmid21736987">{{cite journal| author=Colon NC, Chung DH| title=Neuroblastoma. | journal=Adv Pediatr | year= 2011 | volume= 58 | issue= 1 | pages= 297-311 | pmid=21736987 | doi=10.1016/j.yapd.2011.03.011 | pmc=PMC3668791 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21736987  }} </ref>
A detailed history of presenting [[symptoms]], [[family history]] and other associated [[Symptom|symptoms]] should be undertaken when evaluating a [[patient]] of neuroblastoma. General neuroblastoma symptoms include; [[fever]], [[irritability]], [[fatigue]], [[loss of appetite]] and [[weight loss]]. Other [[symptoms]] depending upon the [[anatomical]] location of neuroblastoma include [[abdominal pain]], [[distension]] and [[constipation]] ([[abdomen]]), [[Dyspnea|shortness of breath]], [[chronic cough]] & [[difficulty swallowing]] ([[posterior mediastinum]]), [[weakness]], [[numbness]], [[paralysis]] ([[retroperitoneum]]), visual defects, facial bruising ([[Head and neck anatomy|head & neck]]) and [[pallor]], [[bone pain]] ([[bone marrow]] [[Metastasis|metastases]]).


==History==
==History==
*When evaluating a patient for neuroblastoma, you should take a detailed history of the presenting symptom (duration, onset, progression), a thorough family history review, and a review of any other associated symptoms. When obtaining the history focus on possible associated syndromes such as:<ref name="wiki"> Medulloblastoma. Wikipedia (2015) https://en.wikipedia.org/wiki/Medulloblastoma Accessed on September 2015</ref>
* A detailed history of presenting [[symptoms]] (duration, onset, progression), a thorough [[family history]] and a review of other other associated [[symptoms]] should be undertaken when evaluating a [[patient]] of neuroblastoma. When obtaining the history focus on possible associated [[Syndrome|syndromes]] as well, such as:<ref>{{Cite journal
| author = [[Sidharth Mahapatra]] & [[Kishore B.. Challagundla]]
| title = Cancer, Neuroblastoma
| year = 2018
| month = January
| pmid = 28846355
}}</ref><ref>{{Cite journal
| author = [[John M. Maris]]
| title = Recent advances in neuroblastoma
| journal = [[The New England journal of medicine]]
| volume = 362
| issue = 23
| pages = 2202–2211
| year = 2010
| month = June
| doi = 10.1056/NEJMra0804577
| pmid = 20558371
}}</ref>
:* [[Neurofibromatosis type 1]] ([[von Recklinghausen disease]])
:* [[Neurofibromatosis type 1]] ([[von Recklinghausen disease]])
:* [[Beckwith-Wiedemann syndrome]]
:* [[Beckwith-Wiedemann syndrome]]
Line 16: Line 33:


==Symptoms==
==Symptoms==
* General symptoms of neuroblastoma include:
* General [[symptoms]] of neuroblastoma include:<ref>{{Cite journal
| author = [[J. W. Duckett]] & [[C. E. Koop]]
| title = Neuroblastoma
| journal = [[The Urologic clinics of North America]]
| volume = 4
| issue = 2
| pages = 285–295
| year = 1977
| month = June
| pmid = 331618
}}</ref><ref>{{Cite journal
| author = [[Nadja C. Colon]] & [[Dai H. Chung]]
| title = Neuroblastoma
| journal = [[Advances in pediatrics]]
| volume = 58
| issue = 1
| pages = 297–311
| year = 2011
| month =
| doi = 10.1016/j.yapd.2011.03.011
| pmid = 21736987
}}</ref>
:* [[Fever]]
:* [[Fever]]
:* [[Irritability]]
:* [[Irritability]]
Line 23: Line 61:
:* [[Weight loss]]
:* [[Weight loss]]


* However, the specific clinical presentation of neuroblastoma is determined by the exact anatomical location of the tumor such as:<ref name="wiki"> Neuroblastoma. Wikipedia (2015) https://en.wikipedia.org/wiki/Neuroblastoma Accessed on October, 7 2015</ref><ref name="O"> Neuroblastoma Childhood: Symptoms and Signs. Cancer.net http://www.cancer.net/cancer-types/neuroblastoma-childhood/symptoms-and-signs Accessed on October, 7 2015</ref><ref name="pmid21736987">{{cite journal| author=Colon NC, Chung DH| title=Neuroblastoma. | journal=Adv Pediatr | year= 2011 | volume= 58 | issue= 1 | pages= 297-311 | pmid=21736987 | doi=10.1016/j.yapd.2011.03.011 | pmc=PMC3668791 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21736987  }} </ref>
* However, the specific clinical presentation of neuroblastoma is determined by the exact [[anatomical]] location of the [[tumor]] such as:<ref name="O">Neuroblastoma Childhood: Symptoms and Signs. Cancer.net http://www.cancer.net/cancer-types/neuroblastoma-childhood/symptoms-and-signs Accessed on October, 7 2015</ref><ref name="pmid21736987">{{cite journal| author=Colon NC, Chung DH| title=Neuroblastoma. | journal=Adv Pediatr | year= 2011 | volume= 58 | issue= 1 | pages= 297-311 | pmid=21736987 | doi=10.1016/j.yapd.2011.03.011 | pmc=PMC3668791 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21736987  }} </ref><ref>{{Cite journal
| author = [[Titilope A. Ishola]] & [[Dai H. Chung]]
| title = Neuroblastoma
| journal = [[Surgical oncology]]
| volume = 16
| issue = 3
| pages = 149–156
| year = 2007
| month = November
| doi = 10.1016/j.suronc.2007.09.005
| pmid = 17976976
}}</ref>


:* '''Neuroblastomas located in the abdomen may present with:'''
:* '''Abdominal neuroblastoma symptoms:'''
::* [[Abdominal pain]]
::* [[Abdominal pain]]
::* [[Abdominal distension]]
::* [[Abdominal distension]]
::* [[Constipation]]
::* [[Constipation]]


:* '''Neuroblastomas located in the posterior mediastinum may present with:'''
:* '''Posterior mediastinum neuroblastoma symptoms:'''
::* [[Shortness of breath]]  
::* [[Shortness of breath]]  
::* Chronic [[cough]]
::* [[Chronic cough]]
::* Difficulty swallowing
::* [[Difficulty swallowing]]
::* Difficulty breathing
::* [[Difficulty breathing]]


:* '''Neuroblastomas located in the retroperitoneum may present with:'''
:* '''Retroperitoneal neuroblastoma symptoms:'''
::* [[Weakness]]
::* [[Weakness]]
::* [[Numbness]]  
::* [[Numbness]]  
::* [[Paralysis]]
::* [[Paralysis]]


:* '''Neuroblastomas located in the head and neck may present with:'''
:* '''Head & neck neuroblastoma symptoms:'''
::* Visual defects
::* Visual defects
::* [[Facial]] [[bruising]]
::* [[Facial]] [[bruising]]
::* [[Facial]] [[swelling]]
::* [[Facial]] [[swelling]]


:* '''Metastatic neuroblastomas lesions located in the bone marrow may present with:'''
:* '''Metastatic neuroblastomas lesions located in the bone marrow symptoms:'''
::* [[Pallor]]
::* [[Pallor]]
::* [[Bone pain]]
::* [[Bone pain]]

Latest revision as of 15:19, 6 March 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD[2]Haytham Allaham, M.D. [3]

Overview

A detailed history of presenting symptoms, family history and other associated symptoms should be undertaken when evaluating a patient of neuroblastoma. General neuroblastoma symptoms include; fever, irritability, fatigue, loss of appetite and weight loss. Other symptoms depending upon the anatomical location of neuroblastoma include abdominal pain, distension and constipation (abdomen), shortness of breath, chronic cough & difficulty swallowing (posterior mediastinum), weakness, numbness, paralysis (retroperitoneum), visual defects, facial bruising (head & neck) and pallor, bone pain (bone marrow metastases).

History

  • A detailed history of presenting symptoms (duration, onset, progression), a thorough family history and a review of other other associated symptoms should be undertaken when evaluating a patient of neuroblastoma. When obtaining the history focus on possible associated syndromes as well, such as:[1][2]

Symptoms

  • However, the specific clinical presentation of neuroblastoma is determined by the exact anatomical location of the tumor such as:[5][6][7]
  • Abdominal neuroblastoma symptoms:
  • Posterior mediastinum neuroblastoma symptoms:
  • Retroperitoneal neuroblastoma symptoms:
  • Head & neck neuroblastoma symptoms:
  • Metastatic neuroblastomas lesions located in the bone marrow symptoms:

References

  1. Sidharth Mahapatra & Kishore B.. Challagundla (2018). "Cancer, Neuroblastoma". PMID 28846355. Unknown parameter |month= ignored (help)
  2. John M. Maris (2010). "Recent advances in neuroblastoma". The New England journal of medicine. 362 (23): 2202–2211. doi:10.1056/NEJMra0804577. PMID 20558371. Unknown parameter |month= ignored (help)
  3. J. W. Duckett & C. E. Koop (1977). "Neuroblastoma". The Urologic clinics of North America. 4 (2): 285–295. PMID 331618. Unknown parameter |month= ignored (help)
  4. Nadja C. Colon & Dai H. Chung (2011). "Neuroblastoma". Advances in pediatrics. 58 (1): 297–311. doi:10.1016/j.yapd.2011.03.011. PMID 21736987.
  5. Neuroblastoma Childhood: Symptoms and Signs. Cancer.net http://www.cancer.net/cancer-types/neuroblastoma-childhood/symptoms-and-signs Accessed on October, 7 2015
  6. Colon NC, Chung DH (2011). "Neuroblastoma". Adv Pediatr. 58 (1): 297–311. doi:10.1016/j.yapd.2011.03.011. PMC 3668791. PMID 21736987.
  7. Titilope A. Ishola & Dai H. Chung (2007). "Neuroblastoma". Surgical oncology. 16 (3): 149–156. doi:10.1016/j.suronc.2007.09.005. PMID 17976976. Unknown parameter |month= ignored (help)

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