Minimal change disease other diagnostic studies: Difference between revisions
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*[[Renal]] [[biopsy]] may be helpful in the diagnosis of [[minimal change disease]]. | *[[Renal]] [[biopsy]] may be helpful in the diagnosis of [[minimal change disease]]. | ||
*Within four weeks of treatment with steroid therapy most of the patients with [[minimal change disease]] (MCD) will respond positively. | *Within four weeks of treatment with [[steroid therapy]] most of the patients with [[minimal change disease]] (MCD) will respond positively. | ||
*Before considering renal biopsy steroid therapy can be initiated in patients who fulfill the following criteria because of the invasive process of the biopsy.<ref name="pmid7205481">{{cite journal |vauthors= |title=The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone. A report of the International Study of Kidney Disease in Children |journal=J. Pediatr. |volume=98 |issue=4 |pages=561–4 |date=April 1981 |pmid=7205481 |doi= |url=}}</ref><ref name="pmid9035508">{{cite journal |vauthors=Norero C, Delucchi A, Lagos E, Rosati P |title=[Initial therapy of primary nephrotic syndrome in children: evaluation in a period of 18 months of two prednisone treatment schedules. Chilean Co-operative Group of Study of Nephrotic Syndrome in Children] |language=Spanish; Castilian |journal=Rev Med Chil |volume=124 |issue=5 |pages=567–72 |date=May 1996 |pmid=9035508 |doi= |url=}}</ref> | *Before considering renal biopsy steroid therapy can be initiated in patients who fulfill the following criteria because of the [[Invasive (medical)|invasive]] process of the biopsy.<ref name="pmid7205481">{{cite journal |vauthors= |title=The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone. A report of the International Study of Kidney Disease in Children |journal=J. Pediatr. |volume=98 |issue=4 |pages=561–4 |date=April 1981 |pmid=7205481 |doi= |url=}}</ref><ref name="pmid9035508">{{cite journal |vauthors=Norero C, Delucchi A, Lagos E, Rosati P |title=[Initial therapy of primary nephrotic syndrome in children: evaluation in a period of 18 months of two prednisone treatment schedules. Chilean Co-operative Group of Study of Nephrotic Syndrome in Children] |language=Spanish; Castilian |journal=Rev Med Chil |volume=124 |issue=5 |pages=567–72 |date=May 1996 |pmid=9035508 |doi= |url=}}</ref> | ||
**Age | **[[Age]] | ||
***Patients must be older than 1 year and less than 12 years. | ***Patients must be older than 1 year and less than 12 years. | ||
**Normal complement levels | **Normal [[complement]] levels | ||
**No signs of hypertension, gross hematuria, or a marked increase in serum creatinine. | **No signs of [[hypertension]], gross [[hematuria]], or a marked increase in [[serum creatinine]]. | ||
* By following this protocol in patients with [[minimal change disease]] we can avoid unnecessary [[Invasive (medical)|invasive]] approach in almost 80% of the patients.<ref name="pmid7205481" /> | |||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Renal biopsy may be helpful in the diagnosis of minimal change disease.
Other Diagnostic Studies
- Renal biopsy may be helpful in the diagnosis of minimal change disease.
- Within four weeks of treatment with steroid therapy most of the patients with minimal change disease (MCD) will respond positively.
- Before considering renal biopsy steroid therapy can be initiated in patients who fulfill the following criteria because of the invasive process of the biopsy.[1][2]
- Age
- Patients must be older than 1 year and less than 12 years.
- Normal complement levels
- No signs of hypertension, gross hematuria, or a marked increase in serum creatinine.
- Age
- By following this protocol in patients with minimal change disease we can avoid unnecessary invasive approach in almost 80% of the patients.[1]
References
- ↑ 1.0 1.1 "The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone. A report of the International Study of Kidney Disease in Children". J. Pediatr. 98 (4): 561–4. April 1981. PMID 7205481.
- ↑ Norero C, Delucchi A, Lagos E, Rosati P (May 1996). "[Initial therapy of primary nephrotic syndrome in children: evaluation in a period of 18 months of two prednisone treatment schedules. Chilean Co-operative Group of Study of Nephrotic Syndrome in Children]". Rev Med Chil (in Spanish; Castilian). 124 (5): 567–72. PMID 9035508.