Milk-alkali syndrome laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
* The following laboratory findings are seen in milk-alkali syndrome: | * The following laboratory findings are seen in milk-alkali syndrome:<ref name="pmid16702792">{{cite journal| author=Beall DP, Henslee HB, Webb HR, Scofield RH| title=Milk-alkali syndrome: a historical review and description of the modern version of the syndrome. | journal=Am J Med Sci | year= 2006 | volume= 331 | issue= 5 | pages= 233-42 | pmid=16702792 | doi=10.1097/00000441-200605000-00001 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16702792 }} </ref><ref name="pmid19252114">{{cite journal| author=Medarov BI| title=Milk-alkali syndrome. | journal=Mayo Clin Proc | year= 2009 | volume= 84 | issue= 3 | pages= 261-7 | pmid=19252114 | doi=10.1016/S0025-6196(11)61144-0 | pmc=2664604 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19252114 }} </ref><ref name="pmid3532984">{{cite journal| author=Kapsner P, Langsdorf L, Marcus R, Kraemer FB, Hoffman AR| title=Milk-alkali syndrome in patients treated with calcium carbonate after cardiac transplantation. | journal=Arch Intern Med | year= 1986 | volume= 146 | issue= 10 | pages= 1965-8 | pmid=3532984 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3532984 }} </ref> | ||
**[[Hypercalcemia]] | **[[Hypercalcemia]] | ||
**[[Metabolic alkalosis]] | **[[Metabolic alkalosis]] | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory Findings
Levels of serum calcium must be obtained, but a full workup must include total/ionized calcium, albumin, phosphate, PTH, PTHrP, vitamin D and TSH. In addition, evaluation of hypercalcemia must include an ECG, which may show a short QT interval.
Overview
Laboratory Findings
- The following laboratory findings are seen in milk-alkali syndrome:[1][2][3]
- Hypercalcemia
- Metabolic alkalosis
- Variable degrees of renal insufficiency
- Phosphorus may be normal or low (phosphorus levels used to be high in the classic milk-alkali syndrome due to the high phosphorus load from cream and milk and the development of acute and chronic renal injury.)
- Vitamin D is usually low, but may be normal or increased if vitamin D supplements are the cause to milk-alkali syndrome. 8
- Parathyroid hormone (PTH) is usually low, but is occasionally normal which may be because of renal insufficiency or a rapid decrease in serum calcium after aggressive therapy with intravenous saline . (7)
- PTH should be checked in order to rule out primary hyperparathyroidism.
References
- ↑ Beall DP, Henslee HB, Webb HR, Scofield RH (2006). "Milk-alkali syndrome: a historical review and description of the modern version of the syndrome". Am J Med Sci. 331 (5): 233–42. doi:10.1097/00000441-200605000-00001. PMID 16702792.
- ↑ Medarov BI (2009). "Milk-alkali syndrome". Mayo Clin Proc. 84 (3): 261–7. doi:10.1016/S0025-6196(11)61144-0. PMC 2664604. PMID 19252114.
- ↑ Kapsner P, Langsdorf L, Marcus R, Kraemer FB, Hoffman AR (1986). "Milk-alkali syndrome in patients treated with calcium carbonate after cardiac transplantation". Arch Intern Med. 146 (10): 1965–8. PMID 3532984.