Milk-alkali syndrome historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

It is named for Charles Hoyt Burnett.^[1]^[2]

- There is limited information about the historical perspective of milk-alkali syndrome.

- In 1915, Sippy designed an antacid regimen to neutralize gastric acidity and promote the healing of peptic ulcer disease .

- The regimen included the hourly administration of milk or cream with Sippy powders (a powder containing 600 mg of magnesium carbonate and 600 mg sodium bicarbonate alternating with a powder containing 600 mg of bismuth subcarbonate and 1200 to 1800 mg of sodium bicarbonate)
- Toxic reactions associated with alkalosis and renal insufficiency were noted shortly thereafter, but the plasma calcium concentration was not measured.
- In 1936, a report associated hypercalcemia with the alkalosis and renal failure in patients treated with the Sippy regime.^[3]
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].

The following are a few famous cases of [disease name]:

↑ Template:WhoNamedIt
↑ Burnett CH, Commons RR, Albright F, Howard JE (1949). "Hypercalcemia without hypercalcuria or hypophosphatemia, calcinosis and renal insufficiency; a syndrome following prolonged intake of milk and alkali". N. Engl. J. Med. 240 (20): 787–94. PMID 18126919.
↑ Beall DP, Scofield RH (March 1995). "Milk-alkali syndrome associated with calcium carbonate consumption. Report of 7 patients with parathyroid hormone levels and an estimate of prevalence among patients hospitalized with hypercalcemia". Medicine (Baltimore). 74 (2): 89–96. PMID 7891547.