Mast cell tumor pathophysiology: Difference between revisions
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Revision as of 16:36, 12 September 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
A mast cell originates from the bone marrow and is normally found throughout the connective tissue of the body. It is a normal component of the immune system and as it releases histamine it is associated with allergic reactions. Mast cells also respond to tissue trauma. Mast cell granules contain histamine, heparin, platelet-activating factor, and other substances. Disseminated mastocytosis is rarely seen in young dogs and cats, while mast cell tumors are a common malignant tumor of the skin in older dogs and cats. Up to 20 to 25 percent of skin tumors in dogs are mast cell tumors,[1] with a similar number in cats.[2]
References
- ↑ Brière C (2002). "Use of a reverse saphenous skin flap for the excision of a grade II mast cell tumor on the hind limb of a dog". Can Vet J. 43 (8): 620–2. PMID 12170840.
- ↑ Johnson T, Schulman F, Lipscomb T, Yantis L (2002). "Histopathology and biologic behavior of pleomorphic cutaneous mast cell tumors in fifteen cats". Vet Pathol. 39 (4): 452–7. PMID 12126148.