Mast cell tumor natural history, complications and prognosis

Jump to: navigation, search

Mast cell tumor Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Mast Cell Tumor from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

Diagnostic criteria

Staging

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography or Ultrasound

CT Scan

MRI

Biopsy

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Mast cell tumor natural history, complications and prognosis On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Mast cell tumor natural history, complications and prognosis

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Mast cell tumor natural history, complications and prognosis

CDC on Mast cell tumor natural history, complications and prognosis

Mast cell tumor natural history, complications and prognosis in the news

Blogs on Mast cell tumor natural history, complications and prognosis

Directions to Hospitals Treating Mast cell tumor

Risk calculators and risk factors for Mast cell tumor natural history, complications and prognosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]

Overview

Common complications of mast cell tumor include episodes of anaphylaxis, osteoporosis, and progression to malignant mastocytosis or mast cell leukemia. The prognosis of mast cell tumor varies with the subtype, location, and extent of the tumor. The cutaneous mastocytosis is associated with the most favorable prognosis and mast cell leukemia is associated with poor prognosis.

Natural History

  • Mast cell tumor usually occurs as a sporadic disease that is often transient and limited in children and progressive in adults.[1]
  • Systemic mastocytosis may develop in childhood cases of urticaria pigmentosa that persist beyond puberty, and in approximately 40% of adults with urticaria pigmentosa, usually of long standing.
  • Patients with mast cell tumor often initially have symptom-free intervals interspersed among symptomatic periods.
  • Over time, symptom-free intervals shorten, and finally symptoms become chronic with intensity which fluctuates but with an overall trend toward steadily increasing intensity.

Complications

Common complications of mast cell tumor include:[1]

Prognosis

The prognosis varies with the location and extent of the tumor:[1]

Subtype Prognosis

Cutaneous mastocytosis

  • Childhood cases: resolve spontaneously
  • Adults: may progress to systemic form

Systemic mastocytosis

Prognosis varies with degree of hematological and organ involvement

  • Indolent systemic mastocytosis: good prognosis
  • Mast cell leukemia: poor prognosis

Localized mastocytosis

  • Mastocytoma: benign tumor with good prognosis
  • Mast cell sarcoma: poor prognosis

References

  1. 1.0 1.1 1.2 Mastocytosis and mast cell disorders.Patient info.http://patient.info/doctor/mastocytosis-and-mast-cell-disorders#ref-20 accessed on March 7th, 2016

Linked-in.jpg