Mast cell tumor classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]

Overview

Classification

Based on the affected organ(s), mast cell tumor may be classified into three subtypes:

  • Cutaneous mastocytosis
  • Systemic mastocytosis
  • Localized mastocytosis

Mast cell tumor may be classified according to WHO classification into seven subtypes:[1]

  • Cutaneous mastocytosis
  • Urticaria pigmentosa
  • Maculopapular cutaneous mastocytosis
  • Diffuse cutaneous mastocytosis
  • Mastocytoma of skin
  • Indolent systemic mastocytosis
  • Smoldering systemic mastocytosis
  • Isolated bone marrow mastocytosis
  • Systemic mastocytosis with an associated (clonal) hematologic non–mast cell lineage disease
  • Aggressive systemic mastocytosis
  • Lymphadenopathic systemic mastocytosis with eosinophilia
  • Mast cell leukemia
  • Typical mast cell leukemia
  • Aleukemic mast cell leukemia
  • Mast cell sarcoma
  • Extracutaneous mastocytoma

References

  1. Patnaik MM, Rindos M, Kouides PA, Tefferi A, Pardanani A (2007). "Systemic mastocytosis: a concise clinical and laboratory review". Arch Pathol Lab Med. 131 (5): 784–91. doi:10.1043/1543-2165(2007)131[784:SMACCA]2.0.CO;2. PMID 17488167.

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