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{{Macrocytic anemia}}
{{Macrocytic anemia}}
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==Overview==
==Overview==
'''Macrocytosis''' is the enlargement of [[red blood cell]]s with near-constant [[haemoglobin]] concentration, and is defined by a [[mean corpuscular volume]] (MCV) of greater than 100 femtolitres (the precise criterion varies between laboratories).  
[[Macrocytic anemia]] are the [[anemia]] which has MCV>100fL. [[Macrocytic anemia]] may be classified into 2 subtypes/groups: [[Megaloblastic anemia]] and  non megaloblastic anemia.
==Classifcation==
 
'''Megaloblastic anemia''' is an [[anemia]] (of [[macrocytic anaemia|macrocytic]] classification) which results from inhibition of DNA synthesis in red blood cell production. It is often due to deficiency of [[vitamin B12]] and/or [[folic acid]]. It can be the result of a lack of [[intrinsic factor]] (which lack interferes with B12 absorption), causing [[pernicious anemia]], or with other antimetabolites which poison DNA production, such as chemotherapeutic agents. It is characterized by many large immature and dysfunctional red blood cells ([[megaloblasts]]) in the bone marrow, and also by hypersegmented or multisegmented [[neutrophil]]s. <ref>Babior BM, Bunn HF, Megaloblastic Anemias.  Harrison’s Principles of Internal Medicine. 13th Ed. 1994: 1726-1732. ISBN 0070323704</ref> <ref>Toh BH, van Driel IR, Gleeson PA.  Mechanisms of Disease: Pernicious Anemia. NEJM 1997;337:1441.</ref>
==Classification==
* [[Macrocytic anemia]] are the anemia which has MCV>100fL
 
* [[Macrocytic anemia]] may be classified into 2 subtypes/groups:<ref name="NaeimNagesh Rao2013">{{cite journal|last1=Naeim|first1=Faramarz|last2=Nagesh Rao|first2=P.|last3=Song|first3=Sophie X.|last4=Grody|first4=Wayne W.|title=Disorders of Red Blood Cells—Anemias|year=2013|pages=675–704|doi=10.1016/B978-0-12-385183-3.00061-9}}</ref><ref name="Erber2011">{{cite journal|last1=Erber|first1=WN|title=Investigation and classification of anemia|year=2011|pages=105–113|doi=10.1016/B978-0-7020-3147-2.00006-7}}</ref><ref name="pmid19787825">{{cite journal |vauthors=Moreno Chulilla JA, Romero Colás MS, Gutiérrez Martín M |title=Classification of anemia for gastroenterologists |journal=World J. Gastroenterol. |volume=15 |issue=37 |pages=4627–37 |date=October 2009 |pmid=19787825 |pmc=2754510 |doi= |url=}}</ref>
** [[Megaloblastic anemia]]
*** [[Vitamin B12 deficiency]]
*** [[Folate deficiency]]
** Non megaloblastic anemia
*** Intrinsic (Myelodyplasia)
*** Extrinsic ([[liver disease]], [[hypothyroidism]])


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
[[es:Anemia megaloblástica]]
 
[[gl:Anemia megaloblástica]]
[[he:אנמיה מגלובלסטית]]
[[it:Anemia megaloblastica]]
[[pl:Niedokrwistość megaloblastyczna]]
[[pt:Anemia megaloblástica]]
[[ru:Пернициозная анемия]]
[[sl:Megaloblastna anemija]]
[[sr:Мегалобластна анемија]]
[[tr:Megaloblastik anemi]]


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Latest revision as of 18:27, 6 November 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2], Omer Kamal, M.D.[3]

Overview

Macrocytic anemia are the anemia which has MCV>100fL. Macrocytic anemia may be classified into 2 subtypes/groups: Megaloblastic anemia and non megaloblastic anemia.

Classification

References

  1. Naeim, Faramarz; Nagesh Rao, P.; Song, Sophie X.; Grody, Wayne W. (2013). "Disorders of Red Blood Cells—Anemias": 675–704. doi:10.1016/B978-0-12-385183-3.00061-9.
  2. Erber, WN (2011). "Investigation and classification of anemia": 105–113. doi:10.1016/B978-0-7020-3147-2.00006-7.
  3. Moreno Chulilla JA, Romero Colás MS, Gutiérrez Martín M (October 2009). "Classification of anemia for gastroenterologists". World J. Gastroenterol. 15 (37): 4627–37. PMC 2754510. PMID 19787825.


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