Liver mass history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]

Overview

The hallmark symptoms of liver mass, include: right upper quadrant abdominal pain, pruritus, and unintentional weight loss. However, in some cases, liver masses may be asymptomatic. A positive history of chronic hepatitis, cirrhosis, nonalcoholic fatty liver disease, prolonged contraceptive use, and alcohol abuse may be suggestive of a liver mass. Symptoms related with liver mass will vary depending on the size and location of the tumor. Other symptoms of liver mass may also include: loss of appetite, fatigue, nausea, and vomiting.

History

  • Obtaining the history is an important aspect of making a diagnosis of liver mass. Complete history will help determine the likelihood of malignancy, and the association with other conditions. Specific symptoms description such as duration, onset, and progression are important for making the diagnosis. Specific areas of focus when obtaining the history, are outlined below:
  • Age
  • Family history of cancer
  • Personal history of cancer
  • Positive family history of liver diseases, such as:
  • Crigler–Najjar
  • Gilbert syndrome
  • Dubin–Johnson syndrome
  • Rotors syndrome
  • Personal history of chronic hepatitis
  • Positive history of smoking/alcohol abuse
  • Number of alcoholic beverages per week
  • Number of years/months of active alcohol abuse
  • Number of years/months of alcohol cessation
  • Use of contraceptives
  • Previous hepatitis infection, such as:
  • Hepatitis C infection
  • Hepatitis B infection

Common Symptoms

  • In most cases, liver masses are asymptomatic and are usually found incidentally.
  • The hallmark symptoms of liver mass, may include: right upper quadrant abdominal pain, pruritus, and unintentional weight loss.
  • Other symptoms that suggest liver mass, include:
  • Dull pain
  • Pain radiating to the right scapular area or right shoulder

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