Liver mass historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]


Liver mass as a separate entity was first described in detail by Hippocrates. He was also the first to differentiate liver abscess from other liver masses. In 1843, Dr. Robert Liston, a British surgeon, was the first to describe hemangioma. In 1911, Yamagiwa suggested a new classification system based on the cell of origin and divided hepatobiliary cancers into hepatocellular cancer and cholangiocellular cancer, with the proposed terminology of hepatoma and cholangioma. In 1958, I Bartok discovered hepatoblastoma for the first time.

Historical Perspective


  1. Liston R (1843). "Case of erectile tumour in the popliteal space.-Removal". Med Chir Trans. 26: 120–32. PMC 2116921. PMID 20895766.
  2. Yamagiwa K. Zum Kenntniss des prim%ren parenchymatosen Leberkarzinoms (“Hepatoma”). Virchows Arch Path Anat 1911;203:75-131.
  3. Okuda K (2002). "Hepatocellular carcinoma--history, current status and perspectives". Dig Liver Dis. 34 (9): 613–6. PMID 12405244.
  4. Madabhavi, Irappa; Patel, Apurva; Choudhary, Mukesh; Aagre, Suhas; Revannasiddaiah, Swaroop; Modi, Gaurang; Anand, Asha; Panchal, Harsha; Parikh, Sonia; Raut, Shreeniwas (2014). "Paraneoplastic Recurrent Hypoglycaemic Seizures: An Initial Presentation of Hepatoblastoma in an Adolescent Male—A Rare Entity". Case Reports in Pediatrics. 2014: 1–5. doi:10.1155/2014/104543. ISSN 2090-6803.
  5. Barthelmes L, Tait IS (2005). "Liver cell adenoma and liver cell adenomatosis". HPB (Oxford). 7 (3): 186–96. doi:10.1080/13651820510028954. PMC 2023950. PMID 18333188.
  6. Baum JK, Bookstein JJ, Holtz F, Klein EW (1973). "Possible association between benign hepatomas and oral contraceptives". Lancet. 2 (7835): 926–9. PMID 4126557.