Langerhans cell histiocytosis laboratory tests: Difference between revisions
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{{Langerhans cell histiocytosis}} | {{Langerhans cell histiocytosis}} | ||
{{CMG}} | {{CMG}} | ||
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== | ==Overview== | ||
==Laboratory Findings== | |||
Diagnosis of LCH is confirmed [[histologically]] by [[tissue]] [[biopsy]]. | Diagnosis of LCH is confirmed [[histologically]] by [[tissue]] [[biopsy]]. | ||
<br />Haemotoxilin-eosin stain of biopsy slide will show features of Langerhans cell e.g. distinct cell margin, pink granular [[cytoplasm]]. Presence of [[Birbeck granules]] on [[electron microscopy]] and [[immuno-cytochemistry|immuno-cytochemical]] features e. g. [[CD1]] positivity are more specific. | <br />Haemotoxilin-eosin stain of biopsy slide will show features of Langerhans cell e.g. distinct cell margin, pink granular [[cytoplasm]]. Presence of [[Birbeck granules]] on [[electron microscopy]] and [[immuno-cytochemistry|immuno-cytochemical]] features e. g. [[CD1]] positivity are more specific. | ||
<br />Initially routine blood tests e.g. full blood count, liver function test, U&Es, bone profile are done to determine disease extent and rule out other causes. | <br />Initially routine blood tests e.g. full blood count, liver function test, U&Es, bone profile are done to determine disease extent and rule out other causes. | ||
Assessment of [[endocrine]] function and | Assessment of [[endocrine]] function and bone marrow biopsy are also performed when indicated. | ||
==References== | ==References== | ||
Revision as of 19:12, 13 September 2012
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Overview
Laboratory Findings
Diagnosis of LCH is confirmed histologically by tissue biopsy.
Haemotoxilin-eosin stain of biopsy slide will show features of Langerhans cell e.g. distinct cell margin, pink granular cytoplasm. Presence of Birbeck granules on electron microscopy and immuno-cytochemical features e. g. CD1 positivity are more specific.
Initially routine blood tests e.g. full blood count, liver function test, U&Es, bone profile are done to determine disease extent and rule out other causes.
Assessment of endocrine function and bone marrow biopsy are also performed when indicated.