Landau-Kleffner syndrome
For patient information, click here Template:DiseaseDisorder infobox
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: Infantile acquired aphasia; acquired epileptic aphasia; aphasia with convulsive disorder
Overview
Landau-Kleffner syndrome is a rare, childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram (EEG). Landau-Kleffner syndrome affects the parts of the brain that control comprehension and speech. Typically, children with LKS develop normally but then lose their language skills. While many of the affected individuals have clinical seizures, some only have electrographic seizures, including electrographic status epilepticus of sleep (ESES).
Approximately 80 percent of the children with LKS have one or more epileptic seizures that usually occur at night. Behavioral disorders such as hyperactivity, aggressiveness and depression can also accompany this disorder.
Historical Perspective
This syndrome was first described in 1957 by Dr. William M. Landau and Dr. Frank R. Kleffner, who identified six children with the disorder.
Pathophysiology
All of the children with LKS appear to be perfectly normal until their first seizure or the start of language problems. There have been no reports of children who have a family history of LKS. Therefore, LKS is not likely to be an inherited disorder.
Causes
The cause of LKS is unknown. Some experts think there is more than one cause for this disorder.
Differential diagnosis
The syndrome can be difficult to diagnose and may be misdiagnosed as autism, pervasive developmental disorder, hearing impairment, learning disability, auditory/verbal processing disorder,attention deficit disorder, mental retardation, childhood schizophrenia, or emotional/behavioral problems. It can be confused with other epileptic disorders and can be differentiated depending upon the cognitive and behavioral regression.
| Disease | Clinical Features | EEG Patterns |
|---|---|---|
| Autistic epileptiform regression[1] | Global regression during the second year that encompasses social skills | Centrotemporal spikes |
| Acquired epileptic aphasia[2] | Developmental language disturbance, autistic features | Epileptic spikes, electrical status epilepticus of sleep |
| Electrical status epilepticus of sleep[3] | Global regression or auditory agnosia | Electrical status epilepticus of sleep |
Epidemiology and Demographics
Since description, almost 200 cases have been reported.[4]
Age
Over 50% of the affected children present between the ages of three and eight years.
Gender
There appears to be a male preponderance in an approximate male: female ratio of 2:1.
Natural History, Complications and Prognosis
Natural History
Generally, earlier manifestation of the disease correlates with poorer language recovery, and with the appearance of night seizures that last for longer than 36 months. LKS has a wide range of symptom differences and lacks a uniformity in diagnostic criteria between cases, and many studies don't include follow-ups on the patients, so no other relationships between symptoms and recovery have been made known
Prognosis
There have not been many long-term follow-up studies of children with LKS. This lack of evidence, along with the wide range of differences among affected children, makes it impossible to predict the outcome of this disorder. Complete language recovery has been reported; however, language problems usually continue into adulthood. The continued language problems can range from difficulty following simple commands to no verbal communication. If recovery takes place, it can occur within days or years. So far, no relationship has been found between the extent of the language impairment, the presence or absence of seizures and the amount of language recovery. Generally, the earlier the disorder begins, the poorer the language recovery.
Diagnosis
Symptoms
Physical Examination
Laboratory Findings=
LKS occurs most frequently in normally developing children who are between 3 and 7 years of age. For no apparent reason, these children begin having trouble understanding what is said to them. Doctors often refer to this problem as auditory agnosiaor "word deafness." The auditory agnosia may occur slowly or very quickly. Parents often think that the child is developing a hearing problem or has become suddenly deaf. Hearing tests, however, show normal hearing. Children may also appear to be autistic or developmentally delayed.
The inability to understand language eventually affects the child's spoken language which may progress to a complete loss of the ability to speak (mutism). Children who have learned to read and write before the onset of auditory agnosia can often continue communicating through written language. Some children develop a type of gestural communication or sign-like language. The communication problems may lead to behavioral or psychological problems. Intelligence usually appears to be unaffected.
The loss of language may be preceded by an epileptic seizure that usually occurs at night. At some time, 80 percent of children with LKS have one or more seizures. The seizures usually stop by the time the child becomes a teenager. All LKS children have abnormal electrical brain activity on both the right and left sides of their brains.
Treatment
Treatment for LKS usually consists of medications, such as anticonvulsants and corticosteroids, and speech therapy, which should be started early.
Medication to control the seizures and abnormal brain wave activity (anticonvulsants) usually has very little effect on language ability. Corticosteroid therapy has improved the language ability of some children. Sign language instruction has benefited others.
A controversial treatment option involves a surgical technique called multiple subpial transection in which multiple incisions are made through the cortex of the affected part of the brain, severing the axonal tracts in the subjacent white matter.
References
- "Landau-Kleffner syndrome information page". National Institute of Neurological Disorders and Stroke. 2007-02-13. Retrieved 2007-08-23.
- Pearl PL, Carrazana EJ, Holmes GL (2001). "The Landau-Kleffner syndrome". Epilepsy Curr. 1 (2): 39–45. PMID 15309183.
- Rotenberg J, Pearl PL (2003). "Landau-Kleffner syndrome". Arch Neurol. 60 (7): 1019–21. PMID 12873863.
de:Landau-Kleffner-Syndrom no:Landau-Kleffners syndrom fi:Landau-Kleffnerin oireyhtymä
- ↑ Canitano R, Zappella M (2006). "Autistic epileptiform regression". Funct. Neurol. 21 (2): 97–101. PMID 16796825.
- ↑ Deonna T, Roulet-Perez E (2010). "Early-onset acquired epileptic aphasia (Landau-Kleffner syndrome, LKS) and regressive autistic disorders with epileptic EEG abnormalities: the continuing debate". Brain Dev. 32 (9): 746–52. doi:10.1016/j.braindev.2010.06.011. PMID 20637551. Unknown parameter
|month=ignored (help) - ↑ Nickels K, Wirrell E (2008). "Electrical status epilepticus in sleep". Semin Pediatr Neurol. 15 (2): 50–60. doi:10.1016/j.spen.2008.03.002. PMID 18555191. Unknown parameter
|month=ignored (help) - ↑ Bhardwaj P, Sharma VK, Sharma R, Gautam P (2009). "Acquired epileptic aphasia: Landau-Kleffner syndrome". J Pediatr Neurosci. 4 (1): 52–3. doi:10.4103/1817-1745.49114. PMC 3162843. PMID 21887181. Unknown parameter
|month=ignored (help)