IL1F10: Difference between revisions

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{{Infobox_gene}}
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'''Interleukin-1 family member 10''' is a [[protein]] that in humans is encoded by the ''IL1F10'' [[gene]].<ref name="pmid11747621">{{cite journal |vauthors=Bensen JT, Dawson PA, Mychaleckyj JC, Bowden DW | title = Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14 | journal = J Interferon Cytokine Res | volume = 21 | issue = 11 | pages = 899–904 |date=Dec 2001 | pmid = 11747621 | pmc =  | doi = 10.1089/107999001753289505 }}</ref><ref name="pmid11991723">{{cite journal |vauthors=Taylor SL, Renshaw BR, Garka KE, Smith DE, Sims JE | title = Genomic organization of the interleukin-1 locus | journal = Genomics | volume = 79 | issue = 5 | pages = 726–33 |date=May 2002 | pmid = 11991723 | pmc = | doi = 10.1006/geno.2002.6752 }}</ref><ref name="pmid11991722">{{cite journal |vauthors=Nicklin MJ, Barton JL, Nguyen M, FitzGerald MG, Duff GW, Kornman K | title = A sequence-based map of the nine genes of the human interleukin-1 cluster | journal = Genomics | volume = 79 | issue = 5 | pages = 718–25 |date=May 2002 | pmid = 11991722 | pmc =  | doi = 10.1006/geno.2002.6751 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: IL1F10 interleukin 1 family, member 10 (theta)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84639| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Interleukin 1 family, member 10 (theta)
| HGNCid = 15552
| Symbol = IL1F10
| AltSymbols =; FIL1-theta; FKSG75; IL-1HY2; IL1-theta; MGC119831; MGC119832; MGC119833
| OMIM =
| ECnumber =
| Homologene = 17690
  | MGIid = 2652548
| Function = {{GNF_GO|id=GO:0005152 |text = interleukin-1 receptor antagonist activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 84639
    | Hs_Ensembl = ENSG00000136697
    | Hs_RefseqProtein = NP_115945
    | Hs_RefseqmRNA = NM_032556
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 113542018
    | Hs_GenLoc_end = 113549896
    | Hs_Uniprot = Q8WWZ1
    | Mm_EntrezGene = 215274
    | Mm_Ensembl = ENSMUSG00000046845
    | Mm_RefseqmRNA = NM_153077
    | Mm_RefseqProtein = NP_694717
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 24113205
    | Mm_GenLoc_end = 24115829
    | Mm_Uniprot = Q3KNF2
  }}
}}
'''Interleukin 1 family, member 10 (theta)''', also known as '''IL1F10''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IL1F10 interleukin 1 family, member 10 (theta)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84639| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported.<ref name="entrez">{{cite web | title = Entrez Gene: IL1F10 interleukin 1 family, member 10 (theta)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84639| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Nicklin MJ, Weith A, Duff GW |title=A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes. |journal=Genomics |volume=19 |issue= 2 |pages= 382-4 |year= 1994 |pmid= 8188271 |doi= 10.1006/geno.1994.1076 }}
*{{cite journal  |vauthors=Nicklin MJ, Weith A, Duff GW |title=A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes. |journal=Genomics |volume=19 |issue= 2 |pages= 382–4 |year= 1994 |pmid= 8188271 |doi= 10.1006/geno.1994.1076 }}
*{{cite journal | author=Nothwang HG, Strahm B, Denich D, ''et al.'' |title=Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13. |journal=Genomics |volume=41 |issue= 3 |pages= 370-8 |year= 1997 |pmid= 9169134 |doi= 10.1006/geno.1997.4654 }}
*{{cite journal   |vauthors=Nothwang HG, Strahm B, Denich D, etal |title=Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13. |journal=Genomics |volume=41 |issue= 3 |pages= 370–8 |year= 1997 |pmid= 9169134 |doi= 10.1006/geno.1997.4654 }}
*{{cite journal | author=Mulero JJ, Pace AM, Nelken ST, ''et al.'' |title=IL1HY1: A novel interleukin-1 receptor antagonist gene. |journal=Biochem. Biophys. Res. Commun. |volume=263 |issue= 3 |pages= 702-6 |year= 1999 |pmid= 10512743 |doi= 10.1006/bbrc.1999.1440 }}
*{{cite journal   |vauthors=Mulero JJ, Pace AM, Nelken ST, etal |title=IL1HY1: A novel interleukin-1 receptor antagonist gene. |journal=Biochem. Biophys. Res. Commun. |volume=263 |issue= 3 |pages= 702–6 |year= 1999 |pmid= 10512743 |doi= 10.1006/bbrc.1999.1440 }}
*{{cite journal | author=Smith DE, Renshaw BR, Ketchem RR, ''et al.'' |title=Four new members expand the interleukin-1 superfamily. |journal=J. Biol. Chem. |volume=275 |issue= 2 |pages= 1169-75 |year= 2000 |pmid= 10625660 |doi=  }}
*{{cite journal   |vauthors=Smith DE, Renshaw BR, Ketchem RR, etal |title=Four new members expand the interleukin-1 superfamily. |journal=J. Biol. Chem. |volume=275 |issue= 2 |pages= 1169–75 |year= 2000 |pmid= 10625660 |doi=10.1074/jbc.275.2.1169 }}
*{{cite journal | author=Kumar S, McDonnell PC, Lehr R, ''et al.'' |title=Identification and initial characterization of four novel members of the interleukin-1 family. |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10308-14 |year= 2000 |pmid= 10744718 |doi=  }}
*{{cite journal   |vauthors=Kumar S, McDonnell PC, Lehr R, etal |title=Identification and initial characterization of four novel members of the interleukin-1 family. |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10308–14 |year= 2000 |pmid= 10744718 |doi=10.1074/jbc.275.14.10308 }}
*{{cite journal | author=Busfield SJ, Comrack CA, Yu G, ''et al.'' |title=Identification and gene organization of three novel members of the IL-1 family on human chromosome 2. |journal=Genomics |volume=66 |issue= 2 |pages= 213-6 |year= 2000 |pmid= 10860666 |doi= 10.1006/geno.2000.6184 }}
*{{cite journal   |vauthors=Busfield SJ, Comrack CA, Yu G, etal |title=Identification and gene organization of three novel members of the IL-1 family on human chromosome 2. |journal=Genomics |volume=66 |issue= 2 |pages= 213–6 |year= 2000 |pmid= 10860666 |doi= 10.1006/geno.2000.6184 }}
*{{cite journal | author=Barton JL, Herbst R, Bosisio D, ''et al.'' |title=A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities. |journal=Eur. J. Immunol. |volume=30 |issue= 11 |pages= 3299-308 |year= 2001 |pmid= 11093146 |doi=  }}
*{{cite journal   |vauthors=Barton JL, Herbst R, Bosisio D, etal |title=A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities. |journal=Eur. J. Immunol. |volume=30 |issue= 11 |pages= 3299–308 |year= 2001 |pmid= 11093146 |doi=10.1002/1521-4141(200011)30:11<3299::AID-IMMU3299>3.0.CO;2-S }}
*{{cite journal | author=Pan G, Risser P, Mao W, ''et al.'' |title=IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp. |journal=Cytokine |volume=13 |issue= 1 |pages= 1-7 |year= 2001 |pmid= 11145836 |doi= 10.1006/cyto.2000.0799 }}
*{{cite journal   |vauthors=Pan G, Risser P, Mao W, etal |title=IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp. |journal=Cytokine |volume=13 |issue= 1 |pages= 1–7 |year= 2001 |pmid= 11145836 |doi= 10.1006/cyto.2000.0799 }}
*{{cite journal | author=Lin H, Ho AS, Haley-Vicente D, ''et al.'' |title=Cloning and characterization of IL-1HY2, a novel interleukin-1 family member. |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 20597-602 |year= 2001 |pmid= 11278614 |doi= 10.1074/jbc.M010095200 }}
*{{cite journal   |vauthors=Lin H, Ho AS, Haley-Vicente D, etal |title=Cloning and characterization of IL-1HY2, a novel interleukin-1 family member. |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 20597–602 |year= 2001 |pmid= 11278614 |doi= 10.1074/jbc.M010095200 }}
*{{cite journal | author=Debets R, Timans JC, Homey B, ''et al.'' |title=Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. |journal=J. Immunol. |volume=167 |issue= 3 |pages= 1440-6 |year= 2001 |pmid= 11466363 |doi=  }}
*{{cite journal   |vauthors=Debets R, Timans JC, Homey B, etal |title=Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. |journal=Journal of Immunology |volume=167 |issue= 3 |pages= 1440–6 |year= 2001 |pmid= 11466363 |doi=  10.4049/jimmunol.167.3.1440}}
*{{cite journal | author=Sims JE, Nicklin MJ, Bazan JF, ''et al.'' |title=A new nomenclature for IL-1-family genes. |journal=Trends Immunol. |volume=22 |issue= 10 |pages= 536-7 |year= 2001 |pmid= 11574262 |doi=  }}
*{{cite journal   |vauthors=Sims JE, Nicklin MJ, Bazan JF, etal |title=A new nomenclature for IL-1-family genes. |journal=Trends Immunol. |volume=22 |issue= 10 |pages= 536–7 |year= 2001 |pmid= 11574262 |doi=10.1016/S1471-4906(01)02040-3 }}
*{{cite journal  | author=Bensen JT, Dawson PA, Mychaleckyj JC, Bowden DW |title=Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14. |journal=J. Interferon Cytokine Res. |volume=21 |issue= 11 |pages= 899-904 |year= 2002 |pmid= 11747621 |doi= 10.1089/107999001753289505 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Nicklin MJ, Barton JL, Nguyen M, ''et al.'' |title=A sequence-based map of the nine genes of the human interleukin-1 cluster. |journal=Genomics |volume=79 |issue= 5 |pages= 718-25 |year= 2002 |pmid= 11991722 |doi= 10.1006/geno.2002.6751 }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
*{{cite journal | author=Taylor SL, Renshaw BR, Garka KE, ''et al.'' |title=Genomic organization of the interleukin-1 locus. |journal=Genomics |volume=79 |issue= 5 |pages= 726-33 |year= 2002 |pmid= 11991723 |doi= 10.1006/geno.2002.6752 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Hillier LW, Graves TA, Fulton RS, etal |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
}}
}}
{{refend}}
{{refend}}


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{{Cytokines}}
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Latest revision as of 23:47, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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RefSeq (mRNA)

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Wikidata
View/Edit Human

Interleukin-1 family member 10 is a protein that in humans is encoded by the IL1F10 gene.[1][2][3][4]

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported.[4]

References

  1. ↑ Bensen JT, Dawson PA, Mychaleckyj JC, Bowden DW (Dec 2001). "Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14". J Interferon Cytokine Res. 21 (11): 899–904. doi:10.1089/107999001753289505. PMID 11747621.
  2. ↑ Taylor SL, Renshaw BR, Garka KE, Smith DE, Sims JE (May 2002). "Genomic organization of the interleukin-1 locus". Genomics. 79 (5): 726–33. doi:10.1006/geno.2002.6752. PMID 11991723.
  3. ↑ Nicklin MJ, Barton JL, Nguyen M, FitzGerald MG, Duff GW, Kornman K (May 2002). "A sequence-based map of the nine genes of the human interleukin-1 cluster". Genomics. 79 (5): 718–25. doi:10.1006/geno.2002.6751. PMID 11991722.
  4. ↑ 4.0 4.1 "Entrez Gene: IL1F10 interleukin 1 family, member 10 (theta)".

Further reading



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