Hereditary nonpolyposis colorectal cancer classification: Difference between revisions
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{{CMG}}{{AE}}{{MV}}{{Akram}} | {{CMG}}{{AE}}{{MV}}{{Akram}} | ||
==Overview== | ==Overview== | ||
Hereditary nonpolyposis colorectal cancer may be classified into 2 types: ''Lynch syndrome I'' (familial colon cancer) and ''Lynch syndrome II'' (hereditary nonpolyposis colorectal cancer associated with other cancers). | [[Hereditary nonpolyposis colorectal cancer]] may be classified into 2 types: ''Lynch syndrome I'' (familial colon cancer) and ''Lynch syndrome II'' (hereditary nonpolyposis colorectal cancer associated with other cancers). | ||
==Classification== | ==Classification== | ||
===Lynch Syndrome I | ===Lynch Syndrome I === | ||
* Site-specific colonic cancer | * Site-specific [[Colon cancer|colonic cancer]]. | ||
===Lynch Syndrome II=== | ===Lynch Syndrome II=== | ||
* Includes extracolonic cancer. | * Includes extracolonic [[cancer]]. | ||
* The most common cancer that develop among such patients is endometrial carcinoma | * The most common [[cancer]] that develop among such patients is [[endometrial carcinoma]]. | ||
===Variants=== | ===Variants=== | ||
'''Muir–Torre syndrome'''<ref name="pmid26527831">{{cite journal| author=Mintsoulis D, Beecker J| title=Muir-Torre syndrome. | journal=CMAJ | year= 2016 | volume= 188 | issue= 5 | pages= E95 | pmid=26527831 | doi=10.1503/cmaj.150171 | pmc=4786404 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26527831 }} </ref><ref name="pmid26892655">{{cite journal| author=John AM, Schwartz RA| title=Muir-Torre syndrome (MTS): An update and approach to diagnosis and management. | journal=J Am Acad Dermatol | year= 2016 | volume= 74 | issue= 3 | pages= 558-66 | pmid=26892655 | doi=10.1016/j.jaad.2015.09.074 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26892655 }} </ref><ref name="pmid28256262">{{cite journal| author=Velter C, Caussade P, Fricker JP, Cribier B| title=[Muir-Torre syndrome and Turcot syndrome]. | journal=Ann Dermatol Venereol | year= 2017 | volume= 144 | issue= 8-9 | pages= 525-529 | pmid=28256262 | doi=10.1016/j.annder.2017.01.017 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28256262 }} </ref> | '''Muir–Torre syndrome'''<ref name="pmid26527831">{{cite journal| author=Mintsoulis D, Beecker J| title=Muir-Torre syndrome. | journal=CMAJ | year= 2016 | volume= 188 | issue= 5 | pages= E95 | pmid=26527831 | doi=10.1503/cmaj.150171 | pmc=4786404 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26527831 }} </ref><ref name="pmid26892655">{{cite journal| author=John AM, Schwartz RA| title=Muir-Torre syndrome (MTS): An update and approach to diagnosis and management. | journal=J Am Acad Dermatol | year= 2016 | volume= 74 | issue= 3 | pages= 558-66 | pmid=26892655 | doi=10.1016/j.jaad.2015.09.074 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26892655 }} </ref><ref name="pmid28256262">{{cite journal| author=Velter C, Caussade P, Fricker JP, Cribier B| title=[Muir-Torre syndrome and Turcot syndrome]. | journal=Ann Dermatol Venereol | year= 2017 | volume= 144 | issue= 8-9 | pages= 525-529 | pmid=28256262 | doi=10.1016/j.annder.2017.01.017 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28256262 }} </ref> | ||
::*Hereditary [[autosomal dominant]] syndrome | ::*Hereditary [[autosomal dominant]] syndrome. | ||
::*Considered a subtype of hereditary nonpolyposis colorectal cancer | ::*Considered a subtype of [[Hereditary nonpolyposis colorectal cancer|hereditary nonpolyposis colorectal cancer.]] | ||
::*Individuals are prone to develop cancers of the colon, breast, and genitourinary tract, and skin lesions, such as [[keratoacanthoma]]s and sebaceous tumors | ::*Individuals are prone to develop [[Cancer|cancers]] of the [[Colon Cancer|colon]], [[Breast cancer|breast]], and [[genitourinary tract]], and [[skin lesions]], such as [[keratoacanthoma]]s and [[sebaceous]] [[tumors]]. | ||
::*Genes affected are [[MLH1]], [[MSH2]], and | ::*[[Genes]] affected are [[MLH1]], [[MSH2]], and [[MSH6]], which are involved in [[DNA mismatch repair]]. | ||
'''Turcot syndrome'''<ref name="pmid28256262">{{cite journal| author=Velter C, Caussade P, Fricker JP, Cribier B| title=[Muir-Torre syndrome and Turcot syndrome]. | journal=Ann Dermatol Venereol | year= 2017 | volume= 144 | issue= 8-9 | pages= 525-529 | pmid=28256262 | doi=10.1016/j.annder.2017.01.017 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28256262 }} </ref><ref name="pmid23119205">{{cite journal| author=Dipro S, Al-Otaibi F, Alzahrani A, Ulhaq A, Al Shail E| title=Turcot syndrome: a synchronous clinical presentation of glioblastoma multiforme and adenocarcinoma of the colon. | journal=Case Rep Oncol Med | year= 2012 | volume= 2012 | issue= | pages= 720273 | pmid=23119205 | doi=10.1155/2012/720273 | pmc=3479943 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23119205 }} </ref> | '''Turcot syndrome'''<ref name="pmid28256262">{{cite journal| author=Velter C, Caussade P, Fricker JP, Cribier B| title=[Muir-Torre syndrome and Turcot syndrome]. | journal=Ann Dermatol Venereol | year= 2017 | volume= 144 | issue= 8-9 | pages= 525-529 | pmid=28256262 | doi=10.1016/j.annder.2017.01.017 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28256262 }} </ref><ref name="pmid23119205">{{cite journal| author=Dipro S, Al-Otaibi F, Alzahrani A, Ulhaq A, Al Shail E| title=Turcot syndrome: a synchronous clinical presentation of glioblastoma multiforme and adenocarcinoma of the colon. | journal=Case Rep Oncol Med | year= 2012 | volume= 2012 | issue= | pages= 720273 | pmid=23119205 | doi=10.1155/2012/720273 | pmc=3479943 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23119205 }} </ref> | ||
::*Hereditary [[autosomal recessive]] syndrome | ::*Hereditary [[autosomal recessive]] syndrome. | ||
::*Considered a subtype of hereditary nonpolyposis colorectal cancer | ::*Considered a subtype of [[hereditary nonpolyposis colorectal cancer]]. | ||
::*Individuals are prone to develop intestinal polyposis in addition to CNS tumors such as glioblastoma or medulloblastoma | ::*Individuals are prone to develop intestinal polyposis in addition to [[Brain tumor|CNS tumors]] such as [[glioblastoma]] or [[medulloblastoma]]. | ||
==References== | ==References== | ||
Revision as of 05:26, 11 February 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]Ali Akram, M.B.B.S.[3]
Overview
Hereditary nonpolyposis colorectal cancer may be classified into 2 types: Lynch syndrome I (familial colon cancer) and Lynch syndrome II (hereditary nonpolyposis colorectal cancer associated with other cancers).
Classification
Lynch Syndrome I
- Site-specific colonic cancer.
Lynch Syndrome II
- Includes extracolonic cancer.
- The most common cancer that develop among such patients is endometrial carcinoma.
Variants
- Hereditary autosomal dominant syndrome.
- Considered a subtype of hereditary nonpolyposis colorectal cancer.
- Individuals are prone to develop cancers of the colon, breast, and genitourinary tract, and skin lesions, such as keratoacanthomas and sebaceous tumors.
- Genes affected are MLH1, MSH2, and MSH6, which are involved in DNA mismatch repair.
- Hereditary autosomal recessive syndrome.
- Considered a subtype of hereditary nonpolyposis colorectal cancer.
- Individuals are prone to develop intestinal polyposis in addition to CNS tumors such as glioblastoma or medulloblastoma.
References
- ↑ Mintsoulis D, Beecker J (2016). "Muir-Torre syndrome". CMAJ. 188 (5): E95. doi:10.1503/cmaj.150171. PMC 4786404. PMID 26527831.
- ↑ John AM, Schwartz RA (2016). "Muir-Torre syndrome (MTS): An update and approach to diagnosis and management". J Am Acad Dermatol. 74 (3): 558–66. doi:10.1016/j.jaad.2015.09.074. PMID 26892655.
- ↑ 3.0 3.1 Velter C, Caussade P, Fricker JP, Cribier B (2017). "[Muir-Torre syndrome and Turcot syndrome]". Ann Dermatol Venereol. 144 (8–9): 525–529. doi:10.1016/j.annder.2017.01.017. PMID 28256262.
- ↑ Dipro S, Al-Otaibi F, Alzahrani A, Ulhaq A, Al Shail E (2012). "Turcot syndrome: a synchronous clinical presentation of glioblastoma multiforme and adenocarcinoma of the colon". Case Rep Oncol Med. 2012: 720273. doi:10.1155/2012/720273. PMC 3479943. PMID 23119205.