Hereditary nonpolyposis colorectal cancer epidemiology and demographics

Jump to navigation Jump to search

Hereditary Nonpolyposis Colorectal Cancer Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Hereditary Nonpolyposis Colorectal Cancer from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Hereditary nonpolyposis colorectal cancer epidemiology and demographics On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Hereditary nonpolyposis colorectal cancer epidemiology and demographics

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Hereditary nonpolyposis colorectal cancer epidemiology and demographics

CDC on Hereditary nonpolyposis colorectal cancer epidemiology and demographics

Hereditary nonpolyposis colorectal cancer epidemiology and demographics in the news

Blogs on Hereditary nonpolyposis colorectal cancer epidemiology and demographics

Directions to Hospitals Treating Hereditary nonpolyposis colorectal cancer

Risk calculators and risk factors for Hereditary nonpolyposis colorectal cancer epidemiology and demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]Ali Akram, M.B.B.S.[3]

Overview

Incidence of HNPCC is not well known but it is estimated that 0.5 to 13% of the cases of colorectal cancer are due to hereditary nonpolyposis colorectal cancer. The prevalence of hereditary nonpolyposis colorectal cancer is approximately 2 - 7% of all the diagnosed cases of colorectal cancer. Hereditary nonpolyposis colorectal cancer commonly affects young adult population. The median age of diagnosis is between 40 to 45 years. Hereditary nonpolyposis colorectal cancer affects males and females equally. Hereditary nonpolyposis colorectal cancer usually affects individuals of the white race more commonly. Ethnically-diverse individuals are less likely to develop MMR mutations related with hereditary nonpolyposis colorectal cancer.

Epidemiology and Demographics

Incidence

  • Incidence of HNPCC is not well known but it is estimated that 0.5 to 13% of the cases of colorectal cancer are due to hereditary nonpolyposis colorectal cancer.[1][2]

Prevalence

Age

  • Hereditary nonpolyposis colorectal cancer commonly affects young adult population.
  • The median age of diagnosis is often less than 45 years.[3]

Gender

Race

  • Hereditary nonpolyposis colorectal cancer usually affects individuals of the white race more commonly.
  • Ethnically-diverse individuals are less likely to develop MMR mutations related with hereditary nonpolyposis colorectal cancer.

References

  1. Aaltonen LA, Sankila R, Mecklin JP, Järvinen H, Pukkala E, Peltomäki P; et al. (1994). "A novel approach to estimate the proportion of hereditary nonpolyposis colorectal cancer of total colorectal cancer burden". Cancer Detect Prev. 18 (1): 57–63. PMID 8162607.
  2. Houlston RS, Collins A, Slack J, Morton NE (1992). "Dominant genes for colorectal cancer are not rare". Ann Hum Genet. 56 (Pt 2): 99–103. PMID 1503398.
  3. 3.0 3.1 3.2 Aaltonen LA, Salovaara R, Kristo P, Canzian F, Hemminki A, Peltomäki P, Chadwick RB, Kääriäinen H, Eskelinen M, Järvinen H, Mecklin JP, de la Chapelle A (1998). "Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease". N. Engl. J. Med. 338 (21): 1481–7. doi:10.1056/NEJM199805213382101. PMID 9593786.


Template:WikiDoc Sources Template:WikiDoc Sources