Hepato-biliary diseases

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Normal Liver

View of Liver from the top View of Liver from the bottom

Histopathological Findings of a Normal Liver

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Viral hepatitis

Histopathological Findings in Viral hepatitis

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Histopathological Findings in Viral hepatitis with Fulminant Necrosis

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Liver Dysfunction in other Infectious Diseases [1] [2]

Other Inflammatory Liver Diseases

Alcoholic liver disease

This may cause fatty liver, hepatitis, fibrosis and sclerosis leading to cirrhosis and finally hepatic failure.

Histopathological Findings of Alcoholic Liver Disease

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Toxic Liver Disease

This includes mostly drug-induced hepatotoxicity, which may generate many different patterns over liver disease, including

Liver damage is part of Reye's syndrome.

Histopathological Findings: Liver: Centrilobular Necrosis from Chloroform

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Liver tumors

Malignant neoplasm of liver and intrahepatic bile ducts. The most frequent forms are metastatic malignant neoplasm of liver)

Benign neoplasm of liver include hepatic hemangiomas, hepatic adenomas, and focal nodular hyperplasia (FNH).

End-stage liver disease

Chronic liver diseases like chronic hepatitis, chronic alcohol abuse or chronic toxic liver disease may cause

Cirrhosis may also occur in primary biliary cirrhosis. Rarely, cirrhosis is congenital.

Metabolic diseases (Chapter E in ICD-10)

Vascular Disorders

Cysts

Others

Amyloid degeneration of liver

Gallbladder and biliary tract diseases

Diagnosis

In hepatology, important signs and symptoms include:

Complete Differential Diagnosis of Causes of Hepato-biliary diseases

Autoimmune, Systemic

Cholestatic

Infection

Liver Changes

Metabolic

Other

Treatment

Includes:

Histopathological Findings in Liver Diseases

Liver: Cryptococcosis

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Liver: Cytomegalic inclusion disease

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Liver: Echinococcus cyst

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Liver: Histoplasmosis

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Liver & Spleen in Malaria

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Liver: Alpha-1-antitrypsin deficiency

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Liver: Cardiac sclerosis (cardiac cirrhosis)

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Liver: Centrilobular necrosis from chloroform

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Liver: Chronic active hepatitis, cirrhosis

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Liver: Cirrhosis (micronodular)

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Liver: Congenital cytomegalovirus disease

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Liver: Erythroblastosis fetalis

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Fulminant hepatitis (massive hepatic necrosis)

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Liver: Hepatitis, yellow fever virus

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Herpes hepatitis

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Liver: Traumatic hemorrhage

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Liver: Viral hepatitis

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Liver: Viral hepatitis with fulminant necrosis

Fulminant hepatitis (massive hepatic necrosis) is an acute liver failure (<1 month) resulting in rapid hepatic compensation characterized by synthetic dysfunction (hypoglycemia, coagulopathy), coma (cerebral edema, hepatic encephalopathy) and associated with infectious, renal, pulmonary and metabolic complications.

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Liver: Wilson disease

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References

  1. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
  2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X


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