Hemophilia epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Epidemiology and Demographics
Prevalence:[1]
About 18,000 people in the United States have haemophilia. Currently, about 20,000 males in the United States are living with the disorder. Haemophilia A accounts for around 80% of cases.Haemophilia B (also known as Christmas disease) accounts for the remaining 20% of cases and results from a deficiency of coagulation Factor IX.
Incidence
Each year, about 400 babies are born with the disorder. Haemophilia usually occurs in males and less often in females. Haemophilia is rare, with only about 1 instance in every 10,000 births (or 1 in 5,000 male births) for haemophilia A and 1 in 50,000 births for haemophilia B. The incidence of Haemophilia B is around 1 in 25,000 male births. Haemophilia C (also known as plasma thromboplastin antecedent (PTA) deficiency or Rosenthal syndrome) is the fourth most common coagulation disorder after von Willebrand's disease and haemophilia A and B. In the USA it is thought to affect 1 in 100,000 of the adult population, making it 10% as common as haemophilia A.
Race
Hemophilia affects people from all racial and ethnic groups. However Hemophilia C predominantly occurs in Jews of Ashkenazi descent.
Gender
Hemophilia A and B occurs more often in males and less often in females. Hemophilia C is mild form of Hemophilia affecting both sexes equally.