Hemophilia epidemiology and demographics
Hemophilia epidemiology and demographics On the Web
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The prevalence of hemophilia is estimated to be 20,000 cases in the United States annually. The age-adjusted prevalence of hemophilia in six US states (Oklahoma, Massachusetts, Colorado, Georgia, Louisiana, and New York) in 1994 was 13.4 cases per 100, 000 males. The incidence of hemophilia is estimated to be 1 in 5,000 male births for hemophilia A and 1 in 30,000 births for hemophilia B.
Epidemiology and Demographics
- The mean incidence of hemophilia from 1982-91 was 1 in 5,032 live male births.
- The incidence of congenital hemophilia A is 1 in 5000 boys/men.
- The incidence of congenital hemophilia B is about 1 in 30,000 boys/men.
- 400 hemophilic babies are born every year in the United States.
- The age-adjusted prevalence of hemophilia in six US states (Oklahoma, Massachusetts, Colorado, Georgia, Louisiana, and New York) in 1994 was 13.4 cases per 100, 000 males.
- The prevalence of hemophilia in Swedish population was 13.7 per 100, 000 males in 1980.
- The prevalence of hemophilia in other countries identified through contact with specialized hemophilia treatment centers range from 9.7 to 20.5 per 100, 000 males.
- In the United Kingdom, during 1977-1999, the all-cause mortality rate in severe hemophilia was higher than the corresponding age- and calendar year–specific all-cause mortality rate in the general male population by a factor of 2.69, while for patients with moderate/mild hemophilia it was increased by a factor of 1.19.
- The overall life expectancy of the patients with hemophilia did not notably change between 1972 and 2001.
- AIDS is the main cause of death (26%) and 22% of the deaths are because of hepatitis C.
- Hemophilia affects people from all racial and ethnic groups. However heterozygous factor XI deficiency occurs very frequently among Ashkenazi Jews.
- With an X-linked inheritance pattern, congenital hemophilia exclusively affects boys and/or men.
- Hemophilia C with an autosomal transmission can affect the male and as well as female population.
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