Hemophilia differential diagnosis: Difference between revisions

Latest revision as of 18:45, 13 August 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sabawoon Mirwais, M.B.B.S, M.D.[2]Simrat Sarai, M.D. [3]Vahid Eidkhani, M.D.Fahd Yunus, M.D. [4]

Overview

Hemophilia must be differentiated from other diseases leading to spontaneous bleeding and bleeding following injuries or surgery such as von Willebrand disease, hepatic failure, thrombocytopenia, vitamin K deficiency, disseminated intravascular coagulation, uremia, congenital afibrinogenemia, factor V deficiency, factor X deficiency as seen in amyloid purpura, glanzmann's thrombasthenia, Bernard-Soulier syndrome, factor XII deficiency and C1-inhibitor (C1INH) deficiency.

Differentiating Hemophilia from other Diseases

Hemophilia must be differentiated from other diseases leading to spontaneous bleeding and bleeding following injuries or surgery such as:

Von Willebrand Disease^[1]^[2]
Vitamin K deficiency or Warfarin use^[3]^[4]
Lupus Anticoagulant^[5]
Heparin administration
Disseminated intravascular coagulation^[6]
Dysfibrinogenemia^[7]
Thrombocytopenia
Hepatic failure^[8]^[9]^[10]
Uremia^[11]
Congenital afibrinogenemia^[12]^[13]
Factor V deficiency^[14]^[15]
Amyloid purpura^[16]
Glanzmann's thrombasthenia^[17]
Bernard-Soulier syndrome^[18]^[19]
Factor XII deficiency^[20]^[21]
C1-inhibitor (C1INH) deficiency^[22]^[23]

The most important differential diagnoses are enlisted in the table below:^[24]^[25]^[26]^[27]^[28]^[29]^[30]

	Symptoms			Physical Examination			Lab Findings
Diseases	Clinical Manifestations						Para-clinical Findings									Additional Findings
	Symptoms			Physical Examination			Para-clinical Findings
	Joint Bleeding	Gastrointestinal Bleeding	Genitourinary Bleeding	Skin Bruises	Skeletal Deformity	Muscle Hematoma	CBC	PT	PTT	BT	Factor VIII	Factor IX	Fibrinogen	U/A:RBC	S/E:RBC
Hemophilia A	+	+	+	+	+	+	N	N	↑	N	↓	N	N	+	+	-/+Family history
Hemophilia B	+	+	+	+	+	+	N	N	↑	N	N	↓	N	+	+	-/+Family history
von Willebrand disease	-/+	-/+	-/+	-/+	-/+	-/+	N	N	↑/N	↑	↓/N	N	N	-/+	-/+	-/+Family history
Vitamin K deficiency	-/+	+	-/+	+	-	-/+	N	↑	↑/N	N	N	↓	N	+	+	Mostly in infants/GI disorders
Warfarin Toxicity	-/+	+	-/+	+	-	-/+	N	↑	↑/N	N	N	↓	N	+	+	+Drug history
Platelets disorders	-	-/+	-/+	+	-	-	↓Plt	N	N	↑	N	N	N	-/+	-/+	Cause-based specific findings
Liver Failure	-	+	+	-/+	-	-/+	↓Plt/N	↑	↑	↑/N	↑/N	↓	↑/N	-/+	+	Neurological findings/Ascites

References

↑ Goodeve A (December 2016). "Diagnosing von Willebrand disease: genetic analysis". Hematology Am Soc Hematol Educ Program. 2016 (1): 678–682. doi:10.1182/asheducation-2016.1.678. PMC 6065508. PMID 27913546.
↑ "Diagnosis of von Willebrand's disease. A comparative study of diagnostic tests on nine families with von Willebrand's disease and its differential diagnosis from hemophilia and thrombocytopathy". The American Journal of Medicine. 60 (3): A70. 1976. doi:10.1016/0002-9343(76)90768-3. ISSN 0002-9343.
↑ Napolitano M, Mariani G, Lapecorella M (July 2010). "Hereditary combined deficiency of the vitamin K-dependent clotting factors". Orphanet J Rare Dis. 5: 21. doi:10.1186/1750-1172-5-21. PMC 2913942. PMID 20630065.
↑ Hart C, Schmid S (June 2016). "[Coagulation disorders in the intensive care unit - what is new?]". Dtsch. Med. Wochenschr. (in German). 141 (11): 777–80. doi:10.1055/s-0042-103058. PMID 27254626.
↑ Kumano O, Ieko M, Naito S, Yoshida M, Takahashi N, Suzuki T, Komiyama Y (July 2016). "New formulas for mixing test to discriminate between lupus anticoagulant and acquired hemophilia A". Thromb. Res. 143: 53–7. doi:10.1016/j.thromres.2016.05.004. PMID 27182981.
↑ Matsumoto T, Wada H, Fujimoto N, Toyoda J, Abe Y, Ohishi K, Yamashita Y, Ikejiri M, Hasegawa K, Suzuki K, Imai H, Nakatani K, Katayama N (July 2018). "An Evaluation of the Activated Partial Thromboplastin Time Waveform". Clin. Appl. Thromb. Hemost. 24 (5): 764–770. doi:10.1177/1076029617724230. PMID 28884611.
↑ Hua B, Li K, Lee A, Poon MC, Zhao Y (November 2015). "Coexisting congenital dysfibrinogenemia with a novel mutation in fibrinogen γ chain (γ322 Phe→Ile, Fibrinogen Beijing) and haemophilia B in a family". Haemophilia. 21 (6): 846–51. doi:10.1111/hae.12712. PMID 25982359.
↑ Hartmann M, Szalai C, Saner FH (January 2016). "Hemostasis in liver transplantation: Pathophysiology, monitoring, and treatment". World J. Gastroenterol. 22 (4): 1541–50. doi:10.3748/wjg.v22.i4.1541. PMID 26819521.
↑ Stravitz RT, Ellerbe C, Durkalski V, Schilsky M, Fontana RJ, Peterseim C, Lee WM (May 2018). "Bleeding complications in acute liver failure". Hepatology. 67 (5): 1931–1942. doi:10.1002/hep.29694. PMID 29194678.
↑ Tischendorf M, Miesbach W, Chattah U, Chattah Z, Maier S, Welsch C, Zeuzem S, Lange CM (2016). "Differential Kinetics of Coagulation Factors and Natural Anticoagulants in Patients with Liver Cirrhosis: Potential Clinical Implications". PLoS ONE. 11 (5): e0155337. doi:10.1371/journal.pone.0155337. PMC 4865185. PMID 27171213.
↑ Andrassy K, Ritz E (1985). "Uremia as a cause of bleeding". Am. J. Nephrol. 5 (5): 313–9. doi:10.1159/000166955. PMID 3904449.
↑ Santoro C, Massaro F, Venosi S, Capria S, Baldacci E, Foà R, Mazzucconi MG (July 2016). "Severe Thrombotic Complications in Congenital Afibrinogenemia: A Pathophysiological and Management Dilemma". Semin. Thromb. Hemost. 42 (5): 577–82. doi:10.1055/s-0036-1581103. PMID 27253088.
↑ Stanciakova L, Kubisz P, Dobrotova M, Stasko J (July 2016). "Congenital afibrinogenemia: from etiopathogenesis to challenging clinical management". Expert Rev Hematol. 9 (7): 639–48. doi:10.1080/17474086.2016.1200967. PMID 27291795.
↑ Boujrad S, El Hasbaoui B, Echahdi H, Malih M, Agadr A (2017). "[Factor V congenital deficiency: about a case]". Pan Afr Med J (in French). 27: 182. doi:10.11604/pamj.2017.27.182.12285. PMC 5579429. PMID 28904709.
↑ Thalji N, Camire RM (September 2013). "Parahemophilia: new insights into factor v deficiency". Semin. Thromb. Hemost. 39 (6): 607–12. doi:10.1055/s-0033-1349224. PMID 23893775.
↑ Colucci G, Alberio L, Demarmels Biasiutti F, Lämmle B (2014). "Bilateral periorbital ecchymoses. An often missed sign of amyloid purpura". Hamostaseologie. 34 (3): 249–52. doi:10.5482/HAMO-14-03-0018. PMID 24975676.
↑ Iqbal I, Farhan S, Ahmed N (August 2016). "Glanzmann Thrombasthenia: A Clinicopathological Profile". J Coll Physicians Surg Pak. 26 (8): 647–50. doi:2396 Check |doi= value (help). PMID 27539755.
↑ Boeckelmann D, Hengartner H, Greinacher A, Nowak-Göttl U, Sachs UJ, Peter K, Sandrock-Lang K, Zieger B (September 2017). "Patients with Bernard-Soulier syndrome and different severity of the bleeding phenotype". Blood Cells Mol. Dis. 67: 69–74. doi:10.1016/j.bcmd.2017.01.010. PMID 28131619.
↑ Andrews RK, Berndt MC (September 2013). "Bernard-Soulier syndrome: an update". Semin. Thromb. Hemost. 39 (6): 656–62. doi:10.1055/s-0033-1353390. PMID 23929303.
↑ Fernandes HD, Newton S, Rodrigues JM (June 2018). "Factor XII Deficiency Mimicking Bleeding Diathesis: A Unique Presentation and Diagnostic Pitfall". Cureus. 10 (6): e2817. doi:10.7759/cureus.2817. PMC 6093754. PMID 30128221.
↑ Simão F, Feener EP (2017). "The Effects of the Contact Activation System on Hemorrhage". Front Med (Lausanne). 4: 121. doi:10.3389/fmed.2017.00121. PMC 5534673. PMID 28824910.
↑ Otani IM, Banerji A (August 2017). "Acquired C1 Inhibitor Deficiency". Immunol Allergy Clin North Am. 37 (3): 497–511. doi:10.1016/j.iac.2017.03.002. PMID 28687105.
↑ Castelli R, Cicardi M, Gardinali M, Zingale LC, Savi C, Munari M, Agostoni A (March 1997). "Cardiopulmonary by-pass in a patient with acquired C1 inhibitor deficiency". Int J Artif Organs. 20 (3): 175–7. PMID 9151154.
↑ Hathaway WE (1993)Vitamin K deficiency. Southeast Asian J Trop Med Public Health 24 Suppl 1 ():5-9. PMID: 7886607
↑ Santagostino E, Fasulo MR (2013) Hemophilia a and hemophilia B: different types of diseases? Semin Thromb Hemost 39 (7):697-701. DOI:10.1055/s-0033-1353996 PMID: 24014073
↑ Israels SJ (2015). "Laboratory testing for platelet function disorders". Int J Lab Hematol. 37 Suppl 1: 18–24. doi:10.1111/ijlh.12346. PMID 25976956.
↑ Lechner K, Niessner H, Thaler E (1977) Coagulation abnormalities in liver disease. Semin Thromb Hemost 4 (1):40-56. PMID: 199944
↑ Buga-Corbu I, Arion C (2014) Up to date concepts about Von Willebrand disease and the diagnose of this hemostatic disorder. J Med Life 7 (3):327-34. PMID: 25408749
↑ Giangrande P (2005) Haemophilia B: Christmas disease. Expert Opin Pharmacother 6 (9):1517-24. DOI:10.1517/14656566.6.9.1517 PMID: 16086639
↑ Deaton JG, Bhimji SS. Toxicity, Warfarin. [Updated 2017 May 23]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan-.Available from: https://www.ncbi.nlm.nih.gov/books/NBK431112/

Template:WH Template:WS

[pmid27913546-1] Goodeve A (December 2016). "Diagnosing von Willebrand disease: genetic analysis". Hematology Am Soc Hematol Educ Program. 2016 (1): 678–682. doi:10.1182/asheducation-2016.1.678. PMC 6065508. PMID 27913546.

[2] "Diagnosis of von Willebrand's disease. A comparative study of diagnostic tests on nine families with von Willebrand's disease and its differential diagnosis from hemophilia and thrombocytopathy". The American Journal of Medicine. 60 (3): A70. 1976. doi:10.1016/0002-9343(76)90768-3. ISSN 0002-9343.

[pmid20630065-3] Napolitano M, Mariani G, Lapecorella M (July 2010). "Hereditary combined deficiency of the vitamin K-dependent clotting factors". Orphanet J Rare Dis. 5: 21. doi:10.1186/1750-1172-5-21. PMC 2913942. PMID 20630065.

[pmid27254626-4] Hart C, Schmid S (June 2016). "[Coagulation disorders in the intensive care unit - what is new?]". Dtsch. Med. Wochenschr. (in German). 141 (11): 777–80. doi:10.1055/s-0042-103058. PMID 27254626.

[pmid27182981-5] Kumano O, Ieko M, Naito S, Yoshida M, Takahashi N, Suzuki T, Komiyama Y (July 2016). "New formulas for mixing test to discriminate between lupus anticoagulant and acquired hemophilia A". Thromb. Res. 143: 53–7. doi:10.1016/j.thromres.2016.05.004. PMID 27182981.

[pmid28884611-6] Matsumoto T, Wada H, Fujimoto N, Toyoda J, Abe Y, Ohishi K, Yamashita Y, Ikejiri M, Hasegawa K, Suzuki K, Imai H, Nakatani K, Katayama N (July 2018). "An Evaluation of the Activated Partial Thromboplastin Time Waveform". Clin. Appl. Thromb. Hemost. 24 (5): 764–770. doi:10.1177/1076029617724230. PMID 28884611.

[pmid25982359-7] Hua B, Li K, Lee A, Poon MC, Zhao Y (November 2015). "Coexisting congenital dysfibrinogenemia with a novel mutation in fibrinogen γ chain (γ322 Phe→Ile, Fibrinogen Beijing) and haemophilia B in a family". Haemophilia. 21 (6): 846–51. doi:10.1111/hae.12712. PMID 25982359.

[pmid26819521-8] Hartmann M, Szalai C, Saner FH (January 2016). "Hemostasis in liver transplantation: Pathophysiology, monitoring, and treatment". World J. Gastroenterol. 22 (4): 1541–50. doi:10.3748/wjg.v22.i4.1541. PMID 26819521.

[pmid29194678-9] Stravitz RT, Ellerbe C, Durkalski V, Schilsky M, Fontana RJ, Peterseim C, Lee WM (May 2018). "Bleeding complications in acute liver failure". Hepatology. 67 (5): 1931–1942. doi:10.1002/hep.29694. PMID 29194678.

[pmid27171213-10] Tischendorf M, Miesbach W, Chattah U, Chattah Z, Maier S, Welsch C, Zeuzem S, Lange CM (2016). "Differential Kinetics of Coagulation Factors and Natural Anticoagulants in Patients with Liver Cirrhosis: Potential Clinical Implications". PLoS ONE. 11 (5): e0155337. doi:10.1371/journal.pone.0155337. PMC 4865185. PMID 27171213.

[pmid3904449-11] Andrassy K, Ritz E (1985). "Uremia as a cause of bleeding". Am. J. Nephrol. 5 (5): 313–9. doi:10.1159/000166955. PMID 3904449.

[pmid27253088-12] Santoro C, Massaro F, Venosi S, Capria S, Baldacci E, Foà R, Mazzucconi MG (July 2016). "Severe Thrombotic Complications in Congenital Afibrinogenemia: A Pathophysiological and Management Dilemma". Semin. Thromb. Hemost. 42 (5): 577–82. doi:10.1055/s-0036-1581103. PMID 27253088.

[pmid27291795-13] Stanciakova L, Kubisz P, Dobrotova M, Stasko J (July 2016). "Congenital afibrinogenemia: from etiopathogenesis to challenging clinical management". Expert Rev Hematol. 9 (7): 639–48. doi:10.1080/17474086.2016.1200967. PMID 27291795.

[pmid28904709-14] Boujrad S, El Hasbaoui B, Echahdi H, Malih M, Agadr A (2017). "[Factor V congenital deficiency: about a case]". Pan Afr Med J (in French). 27: 182. doi:10.11604/pamj.2017.27.182.12285. PMC 5579429. PMID 28904709.

[pmid23893775-15] Thalji N, Camire RM (September 2013). "Parahemophilia: new insights into factor v deficiency". Semin. Thromb. Hemost. 39 (6): 607–12. doi:10.1055/s-0033-1349224. PMID 23893775.

[pmid24975676-16] Colucci G, Alberio L, Demarmels Biasiutti F, Lämmle B (2014). "Bilateral periorbital ecchymoses. An often missed sign of amyloid purpura". Hamostaseologie. 34 (3): 249–52. doi:10.5482/HAMO-14-03-0018. PMID 24975676.

[pmid27539755-17] Iqbal I, Farhan S, Ahmed N (August 2016). "Glanzmann Thrombasthenia: A Clinicopathological Profile". J Coll Physicians Surg Pak. 26 (8): 647–50. doi:2396 Check |doi= value (help). PMID 27539755.

[pmid28131619-18] Boeckelmann D, Hengartner H, Greinacher A, Nowak-Göttl U, Sachs UJ, Peter K, Sandrock-Lang K, Zieger B (September 2017). "Patients with Bernard-Soulier syndrome and different severity of the bleeding phenotype". Blood Cells Mol. Dis. 67: 69–74. doi:10.1016/j.bcmd.2017.01.010. PMID 28131619.

[pmid23929303-19] Andrews RK, Berndt MC (September 2013). "Bernard-Soulier syndrome: an update". Semin. Thromb. Hemost. 39 (6): 656–62. doi:10.1055/s-0033-1353390. PMID 23929303.

[pmid30128221-20] Fernandes HD, Newton S, Rodrigues JM (June 2018). "Factor XII Deficiency Mimicking Bleeding Diathesis: A Unique Presentation and Diagnostic Pitfall". Cureus. 10 (6): e2817. doi:10.7759/cureus.2817. PMC 6093754. PMID 30128221.

[pmid28824910-21] Simão F, Feener EP (2017). "The Effects of the Contact Activation System on Hemorrhage". Front Med (Lausanne). 4: 121. doi:10.3389/fmed.2017.00121. PMC 5534673. PMID 28824910.

[pmid28687105-22] Otani IM, Banerji A (August 2017). "Acquired C1 Inhibitor Deficiency". Immunol Allergy Clin North Am. 37 (3): 497–511. doi:10.1016/j.iac.2017.03.002. PMID 28687105.

[pmid9151154-23] Castelli R, Cicardi M, Gardinali M, Zingale LC, Savi C, Munari M, Agostoni A (March 1997). "Cardiopulmonary by-pass in a patient with acquired C1 inhibitor deficiency". Int J Artif Organs. 20 (3): 175–7. PMID 9151154.

[pmid7886607-24] Hathaway WE (1993)Vitamin K deficiency. Southeast Asian J Trop Med Public Health 24 Suppl 1 ():5-9. PMID: 7886607

[pmid24014073-25] Santagostino E, Fasulo MR (2013) Hemophilia a and hemophilia B: different types of diseases? Semin Thromb Hemost 39 (7):697-701. DOI:10.1055/s-0033-1353996 PMID: 24014073

[pmid25976956-26] Israels SJ (2015). "Laboratory testing for platelet function disorders". Int J Lab Hematol. 37 Suppl 1: 18–24. doi:10.1111/ijlh.12346. PMID 25976956.

[pmid199944-27] Lechner K, Niessner H, Thaler E (1977) Coagulation abnormalities in liver disease. Semin Thromb Hemost 4 (1):40-56. PMID: 199944

[pmid25408749-28] Buga-Corbu I, Arion C (2014) Up to date concepts about Von Willebrand disease and the diagnose of this hemostatic disorder. J Med Life 7 (3):327-34. PMID: 25408749

[pmid16086639-29] Giangrande P (2005) Haemophilia B: Christmas disease. Expert Opin Pharmacother 6 (9):1517-24. DOI:10.1517/14656566.6.9.1517 PMID: 16086639

[30] Deaton JG, Bhimji SS. Toxicity, Warfarin. [Updated 2017 May 23]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan-.Available from: https://www.ncbi.nlm.nih.gov/books/NBK431112/

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@@ Line 1: / Line 1: @@
-kipedi__NOTOC__
+__NOTOC__
-{{Hemophilia}}
+[[Image:Home_logo1.png|right|250px|link=https://www.wikidoc.org/index.php/Hemophilia]]
-{{CMG}}; {{AE}} {{Simrat}}
+{{CMG}}; {{AE}} {{Sab}}{{Simrat}}{{VE}}{{FNY}}
 ==Overview==
-Hemophilia must be differentiated from other diseases that lead to spontaneous bleeding and bleeding following injuries or surgery such as [[von Willebrand disease]], liver failure-early or end stage, [[thrombocytopenia]], [[vitamin K deficiency]], [[disseminated intravascular coagulation]], [[uremia]], [[congenital afibrinogenemia]], [[factor V]] deficiency, [[factor X]] deficiency as seen in amyloid purpura, [[glanzmann's thrombasthenia]],  bernard-soulier syndrome, [[factor XII]] deficiency and C1INH deficiency.
+Hemophilia must be differentiated from other diseases leading to spontaneous [[bleeding]] and [[bleeding]] following [[Injury|injuries]] or [[surgery]] such as [[von Willebrand disease]], [[hepatic failure]], [[thrombocytopenia]], [[vitamin K deficiency]], [[disseminated intravascular coagulation]], [[uremia]], [[congenital afibrinogenemia]], [[factor V]] [[deficiency]], [[factor X]] [[deficiency]] as seen in [[amyloid purpura]], [[glanzmann's thrombasthenia]],  [[Bernard-Soulier syndrome]], [[factor XII]] [[deficiency]] and [[C1-inhibitor|C1-inhibitor (C1INH)]] [[deficiency]].
-==Differentiating Hemophilia with other Diseases==
+==Differentiating Hemophilia from other Diseases==
-**[[von Willebrand Disease]]
+Hemophilia must be differentiated from other [[Disease|diseases]] leading to spontaneous [[bleeding]] and [[bleeding]] following [[Injury|injuries]] or [[surgery]] such as:
-**[[vitamin K deficiency]] or [[Warfarin]]
+*[[Von Willebrand Disease]]<ref name="pmid27913546">{{cite journal |vauthors=Goodeve A |title=Diagnosing von Willebrand disease: genetic analysis |journal=Hematology Am Soc Hematol Educ Program |volume=2016 |issue=1 |pages=678–682 |date=December 2016 |pmid=27913546 |pmc=6065508 |doi=10.1182/asheducation-2016.1.678 |url=}}</ref><ref>{{cite journal|title=Diagnosis of von Willebrand's disease. A comparative study of diagnostic tests on nine families with von Willebrand's disease and its differential diagnosis from hemophilia and thrombocytopathy|journal=The American Journal of Medicine|volume=60|issue=3|year=1976|pages=A70|issn=00029343|doi=10.1016/0002-9343(76)90768-3}}</ref>
-**Lupus Anticoagulant
+*[[Vitamin K deficiency]] or [[Warfarin]] use<ref name="pmid20630065">{{cite journal |vauthors=Napolitano M, Mariani G, Lapecorella M |title=Hereditary combined deficiency of the vitamin K-dependent clotting factors |journal=Orphanet J Rare Dis |volume=5 |issue= |pages=21 |date=July 2010 |pmid=20630065 |pmc=2913942 |doi=10.1186/1750-1172-5-21 |url=}}</ref><ref name="pmid27254626">{{cite journal |vauthors=Hart C, Schmid S |title=[Coagulation disorders in the intensive care unit - what is new?] |language=German |journal=Dtsch. Med. Wochenschr. |volume=141 |issue=11 |pages=777–80 |date=June 2016 |pmid=27254626 |doi=10.1055/s-0042-103058 |url=}}</ref>
-**[[Heparin]] Administration
+*[[Lupus anticoagulant|Lupus Anticoagulant]]<ref name="pmid27182981">{{cite journal |vauthors=Kumano O, Ieko M, Naito S, Yoshida M, Takahashi N, Suzuki T, Komiyama Y |title=New formulas for mixing test to discriminate between lupus anticoagulant and acquired hemophilia A |journal=Thromb. Res. |volume=143 |issue= |pages=53–7 |date=July 2016 |pmid=27182981 |doi=10.1016/j.thromres.2016.05.004 |url=}}</ref>
-**[[Disseminated Intravascular Coagulation]]
+*[[Heparin]] administration
-**Dysfibrinogenemia
+*[[Disseminated Intravascular Coagulation|Disseminated intravascular coagulation]]<ref name="pmid28884611">{{cite journal |vauthors=Matsumoto T, Wada H, Fujimoto N, Toyoda J, Abe Y, Ohishi K, Yamashita Y, Ikejiri M, Hasegawa K, Suzuki K, Imai H, Nakatani K, Katayama N |title=An Evaluation of the Activated Partial Thromboplastin Time Waveform |journal=Clin. Appl. Thromb. Hemost. |volume=24 |issue=5 |pages=764–770 |date=July 2018 |pmid=28884611 |doi=10.1177/1076029617724230 |url=}}</ref>
-**Thrombocytopenia
+*[[Familial dysfibrinogenemia|Dysfibrinogenemia]]<ref name="pmid25982359">{{cite journal |vauthors=Hua B, Li K, Lee A, Poon MC, Zhao Y |title=Coexisting congenital dysfibrinogenemia with a novel mutation in fibrinogen γ chain (γ322 Phe→Ile, Fibrinogen Beijing) and haemophilia B in a family |journal=Haemophilia |volume=21 |issue=6 |pages=846–51 |date=November 2015 |pmid=25982359 |doi=10.1111/hae.12712 |url=}}</ref>
-**Early liver failure
+*[[Thrombocytopenia]]
-**End-staged liver failure
+*[[Hepatic failure]]<ref name="pmid26819521">{{cite journal |vauthors=Hartmann M, Szalai C, Saner FH |title=Hemostasis in liver transplantation: Pathophysiology, monitoring, and treatment |journal=World J. Gastroenterol. |volume=22 |issue=4 |pages=1541–50 |date=January 2016 |pmid=26819521 |doi=10.3748/wjg.v22.i4.1541 |url=}}</ref><ref name="pmid29194678">{{cite journal |vauthors=Stravitz RT, Ellerbe C, Durkalski V, Schilsky M, Fontana RJ, Peterseim C, Lee WM |title=Bleeding complications in acute liver failure |journal=Hepatology |volume=67 |issue=5 |pages=1931–1942 |date=May 2018 |pmid=29194678 |doi=10.1002/hep.29694 |url=}}</ref><ref name="pmid27171213">{{cite journal |vauthors=Tischendorf M, Miesbach W, Chattah U, Chattah Z, Maier S, Welsch C, Zeuzem S, Lange CM |title=Differential Kinetics of Coagulation Factors and Natural Anticoagulants in Patients with Liver Cirrhosis: Potential Clinical Implications |journal=PLoS ONE |volume=11 |issue=5 |pages=e0155337 |date=2016 |pmid=27171213 |pmc=4865185 |doi=10.1371/journal.pone.0155337 |url=}}</ref>
-**[[Uremia]]
+*[[Uremia]]<ref name="pmid3904449">{{cite journal |vauthors=Andrassy K, Ritz E |title=Uremia as a cause of bleeding |journal=Am. J. Nephrol. |volume=5 |issue=5 |pages=313–9 |date=1985 |pmid=3904449 |doi=10.1159/000166955 |url=}}</ref>
-**Congenital afibrinogenemia
+*[[Congenital afibrinogenemia]]<ref name="pmid27253088">{{cite journal |vauthors=Santoro C, Massaro F, Venosi S, Capria S, Baldacci E, Foà R, Mazzucconi MG |title=Severe Thrombotic Complications in Congenital Afibrinogenemia: A Pathophysiological and Management Dilemma |journal=Semin. Thromb. Hemost. |volume=42 |issue=5 |pages=577–82 |date=July 2016 |pmid=27253088 |doi=10.1055/s-0036-1581103 |url=}}</ref><ref name="pmid27291795">{{cite journal |vauthors=Stanciakova L, Kubisz P, Dobrotova M, Stasko J |title=Congenital afibrinogenemia: from etiopathogenesis to challenging clinical management |journal=Expert Rev Hematol |volume=9 |issue=7 |pages=639–48 |date=July 2016 |pmid=27291795 |doi=10.1080/17474086.2016.1200967 |url=}}</ref>
-**[[Factor V]] deficiency
+*[[Factor V]] [[deficiency]]<ref name="pmid28904709">{{cite journal |vauthors=Boujrad S, El Hasbaoui B, Echahdi H, Malih M, Agadr A |title=[Factor V congenital deficiency: about a case] |language=French |journal=Pan Afr Med J |volume=27 |issue= |pages=182 |date=2017 |pmid=28904709 |pmc=5579429 |doi=10.11604/pamj.2017.27.182.12285 |url=}}</ref><ref name="pmid23893775">{{cite journal |vauthors=Thalji N, Camire RM |title=Parahemophilia: new insights into factor v deficiency |journal=Semin. Thromb. Hemost. |volume=39 |issue=6 |pages=607–12 |date=September 2013 |pmid=23893775 |doi=10.1055/s-0033-1349224 |url=}}</ref>
-**Amyloid purpura
+*[[Amyloid purpura]]<ref name="pmid24975676">{{cite journal |vauthors=Colucci G, Alberio L, Demarmels Biasiutti F, Lämmle B |title=Bilateral periorbital ecchymoses. An often missed sign of amyloid purpura |journal=Hamostaseologie |volume=34 |issue=3 |pages=249–52 |date=2014 |pmid=24975676 |doi=10.5482/HAMO-14-03-0018 |url=}}</ref>
-**[[Glanzmann's thrombasthenia]]
+*[[Glanzmann's thrombasthenia]]<ref name="pmid27539755">{{cite journal |vauthors=Iqbal I, Farhan S, Ahmed N |title=Glanzmann Thrombasthenia: A Clinicopathological Profile |journal=J Coll Physicians Surg Pak |volume=26 |issue=8 |pages=647–50 |date=August 2016 |pmid=27539755 |doi=2396 |url=}}</ref>
-**Bernard-soulier syndrome
+*[[Bernard-Soulier syndrome]]<ref name="pmid28131619">{{cite journal |vauthors=Boeckelmann D, Hengartner H, Greinacher A, Nowak-Göttl U, Sachs UJ, Peter K, Sandrock-Lang K, Zieger B |title=Patients with Bernard-Soulier syndrome and different severity of the bleeding phenotype |journal=Blood Cells Mol. Dis. |volume=67 |issue= |pages=69–74 |date=September 2017 |pmid=28131619 |doi=10.1016/j.bcmd.2017.01.010 |url=}}</ref><ref name="pmid23929303">{{cite journal |vauthors=Andrews RK, Berndt MC |title=Bernard-Soulier syndrome: an update |journal=Semin. Thromb. Hemost. |volume=39 |issue=6 |pages=656–62 |date=September 2013 |pmid=23929303 |doi=10.1055/s-0033-1353390 |url=}}</ref>
-**[[Factor XII]] deficiency
+*[[Factor XII]] [[deficiency]]<ref name="pmid30128221">{{cite journal |vauthors=Fernandes HD, Newton S, Rodrigues JM |title=Factor XII Deficiency Mimicking Bleeding Diathesis: A Unique Presentation and Diagnostic Pitfall |journal=Cureus |volume=10 |issue=6 |pages=e2817 |date=June 2018 |pmid=30128221 |pmc=6093754 |doi=10.7759/cureus.2817 |url=}}</ref><ref name="pmid28824910">{{cite journal |vauthors=Simão F, Feener EP |title=The Effects of the Contact Activation System on Hemorrhage |journal=Front Med (Lausanne) |volume=4 |issue= |pages=121 |date=2017 |pmid=28824910 |pmc=5534673 |doi=10.3389/fmed.2017.00121 |url=}}</ref>
-**C1INH deficiency<ref>{{Cite web | title =Wikipedia Hemophilia Differential diagnosis| url =https://en.wikipedia.org/wiki/Haemophilia }}</ref>
+*[[C1-inhibitor|C1-inhibitor (C1INH)]] [[deficiency]]<ref name="pmid28687105">{{cite journal |vauthors=Otani IM, Banerji A |title=Acquired C1 Inhibitor Deficiency |journal=Immunol Allergy Clin North Am |volume=37 |issue=3 |pages=497–511 |date=August 2017 |pmid=28687105 |doi=10.1016/j.iac.2017.03.002 |url=}}</ref><ref name="pmid9151154">{{cite journal |vauthors=Castelli R, Cicardi M, Gardinali M, Zingale LC, Savi C, Munari M, Agostoni A |title=Cardiopulmonary by-pass in a patient with acquired C1 inhibitor deficiency |journal=Int J Artif Organs |volume=20 |issue=3 |pages=175–7 |date=March 1997 |pmid=9151154 |doi= |url=}}</ref>
+'''The most important differential diagnoses are enlisted in the table below:'''<ref name="pmid7886607">Hathaway WE (1993)[https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=7886607 Vitamin K deficiency.] ''Southeast Asian J Trop Med Public Health'' 24 Suppl 1 ():5-9. PMID: [https://pubmed.gov/7886607 7886607]</ref><ref name="pmid24014073">Santagostino E, Fasulo MR (2013) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=24014073 Hemophilia a and hemophilia B: different types of diseases?] ''Semin Thromb Hemost'' 39 (7):697-701. [http://dx.doi.org/10.1055/s-0033-1353996 DOI:10.1055/s-0033-1353996] PMID: [https://pubmed.gov/24014073 24014073]</ref><ref name="pmid25976956">{{cite journal| author=Israels SJ| title=Laboratory testing for platelet function disorders. | journal=Int J Lab Hematol | year= 2015 | volume= 37 Suppl 1 | issue=  | pages= 18-24 | pmid=25976956 | doi=10.1111/ijlh.12346 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25976956  }}</ref><ref name="pmid199944">Lechner K, Niessner H, Thaler E (1977) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=199944 Coagulation abnormalities in liver disease.] ''Semin Thromb Hemost'' 4 (1):40-56. PMID: [https://pubmed.gov/199944 199944]</ref><ref name="pmid25408749">Buga-Corbu I, Arion C (2014) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=25408749 Up to date concepts about Von Willebrand disease and the diagnose of this hemostatic disorder.] ''J Med Life'' 7 (3):327-34. PMID: [https://pubmed.gov/25408749 25408749]</ref><ref name="pmid16086639">Giangrande P (2005) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=16086639 Haemophilia B: Christmas disease.] ''Expert Opin Pharmacother'' 6 (9):1517-24. [http://dx.doi.org/10.1517/14656566.6.9.1517 DOI:10.1517/14656566.6.9.1517] PMID: [https://pubmed.gov/16086639 16086639]</ref><ref>Deaton JG, Bhimji SS. Toxicity, Warfarin. [Updated 2017 May 23]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan-.Available from: <nowiki>https://www.ncbi.nlm.nih.gov/books/NBK431112/</nowiki></ref>
+{|
+|- style="background: #4479BA; color: #FFFFFF; text-align: center;"
+! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Diseases
+| colspan="6" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Clinical Manifestations'''
+! colspan="9" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Para-clinical Findings
+! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Additional Findings
+|-
+| colspan="3" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Symptoms'''
+! colspan="3" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physical Examination
+|-
+! colspan="9" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings
+|-
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Joint Bleeding
+! colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gastrointestinal Bleeding
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Genitourinary Bleeding
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Skin Bruises
+! colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Skeletal Deformity
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Muscle Hematoma
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |CBC
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PT
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PTT
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BT
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Factor VIII
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Factor IX
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fibrinogen
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |[[Urinalysis|U/A]]:RBC
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |S/E:RBC
+|-
+! style="background: #DCDCDC; padding: 5px; text-align: center;" |Hemophilia A
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |        '''<big>+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |      '''<big>+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |          '''<big>+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>+</big>'''
+! style="background: #F5F5F5; padding: 5px; text-align: center;" |N
+! style="background: #F5F5F5; padding: 5px; text-align: center;" |N
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |<big>'''↑'''</big>
+! style="background: #F5F5F5; padding: 5px; text-align: center;" |N
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |  '''<big>↓</big>'''
+! style="background: #F5F5F5; padding: 5px; text-align: center;" |N
+! style="background: #F5F5F5; padding: 5px; text-align: center;" |N
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" | -/+Family history
+|-
+! style="background: #DCDCDC; padding: 5px; text-align: center;" |Hemophilia B
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>+</big>'''
+! style="background: #F5F5F5; padding: 5px; text-align: center;" |N
+! style="background: #F5F5F5; padding: 5px; text-align: center;" |N
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |<big>'''↑'''</big>
+! style="background: #F5F5F5; padding: 5px; text-align: center;" |N
+! style="background: #F5F5F5; padding: 5px; text-align: center;" |N
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>↓</big>'''
+! style="background: #F5F5F5; padding: 5px; text-align: center;" |N
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" | -/+Family history
+|-
+! style="background: #DCDCDC; padding: 5px; text-align: center;" |[[von Willebrand disease]]
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-/+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-/+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-/+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-/+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-/+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-/+</big>'''
+! style="background: #F5F5F5; padding: 5px; text-align: center;" |N
+! style="background: #F5F5F5; padding: 5px; text-align: center;" |N
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>↑/</big>N'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |<big>'''↑'''</big>
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |  '''<big>↓/</big>N'''
+! style="background: #F5F5F5; padding: 5px; text-align: center;" |N
+! style="background: #F5F5F5; padding: 5px; text-align: center;" |N
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-/+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-/+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" | -/+Family history
+|-
+! style="background: #DCDCDC; padding: 5px; text-align: center;" |Vitamin K deficiency
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-/+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-/+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-/+</big>'''
+! style="background: #F5F5F5; padding: 5px; text-align: center;" |N
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |<big>'''↑'''</big>
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>↑/</big>N'''
+! style="background: #F5F5F5; padding: 5px; text-align: center;" |N
+! style="background: #F5F5F5; padding: 5px; text-align: center;" |N
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>↓</big>'''
+! style="background: #F5F5F5; padding: 5px; text-align: center;" |N
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |Mostly in infants/GI disorders
+|-
+! style="background: #DCDCDC; padding: 5px; text-align: center;" |Warfarin Toxicity
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-/+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |  '''<big>+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-/+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-/+</big>'''
+! style="background: #F5F5F5; padding: 5px; text-align: center;" |N
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |<big>'''↑'''</big>
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>↑/</big>N'''
+! style="background: #F5F5F5; padding: 5px; text-align: center;" |N
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''N'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>↓</big>'''
+! style="background: #F5F5F5; padding: 5px; text-align: center;" |N
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" | +Drug history
+|-
+! style="background: #DCDCDC; padding: 5px; text-align: center;" |Platelets disorders
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-/+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-/+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>↓Plt</big>'''
+! style="background: #F5F5F5; padding: 5px; text-align: center;" |N
+! style="background: #F5F5F5; padding: 5px; text-align: center;" |N
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |<big>'''↑'''</big>
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''N'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''N'''
+! style="background: #F5F5F5; padding: 5px; text-align: center;" |N
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-/+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-/+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |Cause-based specific findings
+|-
+! style="background: #DCDCDC; padding: 5px; text-align: center;" |Liver Failure
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-/+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-/+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>↓Plt/N</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |<big>'''↑'''</big>
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |<big>'''↑'''</big>
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>↑/</big>N'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>↑/</big>N'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>↓</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>↑/</big>N'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>-/+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |'''<big>+</big>'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;" |Neurological findings/Ascites
+|}
 ==References==

Hemophilia differential diagnosis: Difference between revisions

Latest revision as of 18:45, 13 August 2019

Overview

Differentiating Hemophilia from other Diseases

References

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