Uremia
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| Uremia Classification and external resources | |
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| Urea | |
| ICD-10 | R39.2 |
| ICD-9 | 585-586, 788.9 |
| DiseasesDB | 26060 |
| eMedicine | med/2341 |
| MeSH | D014511 |
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Ongoing Trials on Uremia at Clinical Trials.gov Clinical Trials on Uremia at Google
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US National Guidelines Clearinghouse on Uremia
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Uremia is a term used to loosely describe the illness accompanying kidney failure. In kidney failure, urea and other waste products, which are normally excreted into the urine, are retained in the blood. Early symptoms include anorexia and lethargy, and late symptoms can include decreased mental acuity and coma. It is usually diagnosed in kidney dialysis patients when the glomerular filtration rate, a measure of kidney function, is below 50% of normal.[1]
Azotemia is another word that refers to high levels of urea, but is used primarily when the abnormality can be measured chemically but is not yet so severe as to produce symptoms. Uremia can also result in fibrinous pericarditis. There are many dysfunctions caused by uremia affecting many systems of the body, such as blood (lower levels of erythropoietin), Sex (lower levels of testosterone/oestrogen) and bones (osteoperosis and metastatic calcifications).
Causes
Besides renal failure, the level of urea in the blood can also be increased by:
- increased production of urea in the liver, due to:
- high protein diet
- increased protein breakdown (surgery, infection, trauma, cancer)
- gastrointestinal bleeding
- drugs (e.g. tetracyclines and corticosteroids)
- decreased elimination of urea, due to:
- decreased blood flow through kidney (e.g. hypotension, cardiac failure)
- urinary outflow obstruction
- dehydration
See also
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
