Amyloid purpura

Jump to: navigation, search

WikiDoc Resources for

Amyloid purpura

Articles

Most recent articles on Amyloid purpura

Most cited articles on Amyloid purpura

Review articles on Amyloid purpura

Articles on Amyloid purpura in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Amyloid purpura

Images of Amyloid purpura

Photos of Amyloid purpura

Podcasts & MP3s on Amyloid purpura

Videos on Amyloid purpura

Evidence Based Medicine

Cochrane Collaboration on Amyloid purpura

Bandolier on Amyloid purpura

TRIP on Amyloid purpura

Clinical Trials

Ongoing Trials on Amyloid purpura at Clinical Trials.gov

Trial results on Amyloid purpura

Clinical Trials on Amyloid purpura at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Amyloid purpura

NICE Guidance on Amyloid purpura

NHS PRODIGY Guidance

FDA on Amyloid purpura

CDC on Amyloid purpura

Books

Books on Amyloid purpura

News

Amyloid purpura in the news

Be alerted to news on Amyloid purpura

News trends on Amyloid purpura

Commentary

Blogs on Amyloid purpura

Definitions

Definitions of Amyloid purpura

Patient Resources / Community

Patient resources on Amyloid purpura

Discussion groups on Amyloid purpura

Patient Handouts on Amyloid purpura

Directions to Hospitals Treating Amyloid purpura

Risk calculators and risk factors for Amyloid purpura

Healthcare Provider Resources

Symptoms of Amyloid purpura

Causes & Risk Factors for Amyloid purpura

Diagnostic studies for Amyloid purpura

Treatment of Amyloid purpura

Continuing Medical Education (CME)

CME Programs on Amyloid purpura

International

Amyloid purpura en Espanol

Amyloid purpura en Francais

Business

Amyloid purpura in the Marketplace

Patents on Amyloid purpura

Experimental / Informatics

List of terms related to Amyloid purpura


Amyloid purpura is a condition marked by bleeding under the skin (purpura) in some individuals with amyloidosis.[1] Its cause is unknown, but coagulation defects caused by amyloid are thought to contribute.

Cause

The precise cause of amyloid purpura is unknown, but several mechanisms are thought to contribute.[2] One may be a decrease in the level of circulating factor X,[2] a clotting factor necessary for coagulation. The proposed mechanism for this decrease in factor X is that circulating amyloid fibrils bind and inactivate factor X.[2] Another contributing factor may be enhanced fibrinolysis,[2] the breakdown of clots. Subendothelial deposits of amyloid may weaken blood vessels and lead to the extravasation of blood.[2][3] Amyloid deposits in the gastrointestinal tract and liver may also play a role in the development of amyloid purpura.[2]

Distribution

Amyloid purpura usually occurs in the webbing of the neck and in the face.[2]

Epidemiology

Amyloid purpura affects a minority of individuals with amyloidosis.[1] For example, purpura is present early in the disease in approximately 15% of patients with primary systemic amyloidosis.[4]

References

  1. 1.0 1.1 Eder L, Bitterman H (June 2007). "Image in clinical medicine. Amyloid purpura". N. Engl. J. Med. 356 (23): 2406. doi:10.1056/NEJMicm061510. PMID 17554122.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Gamba G, Montani N, Anesi E, et al (March 2000). "Clotting alterations in primary systemic amyloidosis". Haematologica 85 (3): 289–92. PMID 10702818.
  3. Amyloidosis, Immunoglobulin-Related at eMedicine
  4. Kyle RA, Gertz MA (January 1995). "Primary systemic amyloidosis: clinical and laboratory features in 474 cases". Semin. Hematol. 32 (1): 45–59. PMID 7878478.

Amyloidosis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Amyloidosis from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography

Other Imaging Findings

Treatment

Medical Therapy

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Amyloid purpura On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Amyloid purpura

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Amyloid purpura

CDC on Amyloid purpura

Amyloid purpura in the news

Blogs on Amyloid purpura</small>

Directions to Hospitals Treating Amyloidosis

Risk calculators and risk factors for Amyloid purpura


Linked-in.jpg