Hairy cell leukemia laboratory tests

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Laboratory findings consistent with the diagnosis of hairy cell leukemia include abnormal complete blood count, immunohistochemistry, and flow cytometry. The presence of hairy cells with thread-like cytoplasmic extensions on blood smear is a key diagnostic feature among patients with hairy cell leukemia.

Laboratory Findings

Complete Blood Count

Blood Smear

  • Hairy cells with thread-like cytoplasmic extensions[1]
  • Positive TRAP stain

Immunohistochemistry

  • On immunohistochemistry, characteristic findings of hairy cell leukemia include:[1]

Flow Cytometry

  • On flow cytometry, characteristic findings of hairy cell leukemia include:[1]

References

  1. 1.0 1.1 1.2 1.3 Somasundaram V, Purohit A, Aggarwal M, Manivannan P, Mishra P, Seth T, Tyagi S, Mahapatra M, Pati HP, Saxena R (2014). "Hairy cell leukemia: A decade long experience of North Indian Hematology Center". Indian J Med Paediatr Oncol. 35 (4): 271–5. doi:10.4103/0971-5851.144988. PMC 4264273. PMID 25538404.


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