Hairy cell leukemia risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]; Grammar Reviewer: Natalie Harpenau, B.S.[3]
Overview
The most potent risk factor in the development of hairy cell leukemia is chemical exposure. Other risk factors include radiation exposure, UV light and sawdust exposure.
Risk Factors
| Risk Factor | Description |
|---|---|
| Chemical exposure | Exposure to either herbicides or diesel may be correlated with an increased risk of hairy cell leukemia. |
| Radiation exposure |
Excessive X-ray imaging or prior radiotherapy may be associated with increased risk of hairy cell leukemia. |
| Sawdust exposure | Occupations that involve exposure to sawdust and wood may be associated with increased risk of hairy cell leukemia development. |
| Ethnicity | Hairy cell leukemia usually more commonly affects individuals of the Ashkenazi Jewish ancestry. |
| Gender | Males are more commonly affected with hairy cell leukemia than females. |
| Age | The chance to develop hairy cell leukemia increases as patients get older, while it is rarely diagnosed in patients younger than 30 years of age. |
| HLA haplotype | Family members who are sharing the same HLA haplotype are at increased risk for hairy cell leukemia. |
References
- ↑ Monnereau A, Slager SL, Hughes AM, Smith A, Glimelius B, Habermann TM, Berndt SI, Staines A, Norman AD, Cerhan JR, Sampson JN, Morton LM, Clavel J (August 2014). "Medical history, lifestyle, and occupational risk factors for hairy cell leukemia: the InterLymph Non-Hodgkin Lymphoma Subtypes Project". J. Natl. Cancer Inst. Monographs. 2014 (48): 115–24. doi:10.1093/jncimonographs/lgu004. PMC 4155459. PMID 25174032.
- ↑ Nordström M, Hardell L, Magnusson A, Hagberg H, Rask-Andersen A (October 1997). "Occupation and occupational exposure to UV light as risk factors for hairy cell leukaemia evaluated in a case-control study". Eur. J. Cancer Prev. 6 (5): 467–72. PMID 9466117.
- ↑ Orsi L, Delabre L, Monnereau A, Delval P, Berthou C, Fenaux P, Marit G, Soubeyran P, Huguet F, Milpied N, Leporrier M, Hemon D, Troussard X, Clavel J (May 2009). "Occupational exposure to pesticides and lymphoid neoplasms among men: results of a French case-control study". Occup Environ Med. 66 (5): 291–8. doi:10.1136/oem.2008.040972. PMC 2728754. PMID 19017688.
- ↑ Stewart DJ, Keating MJ (October 1980). "Radiation exposure as a possible etiologic factor in hairy cell leukemia (leukemic reticuloendotheliosis)". Cancer. 46 (7): 1577–80. PMID 7417955.
- ↑ Clavel J, Mandereau L, Cordier S, Le Goaster C, Hémon D, Conso F, Flandrin G (September 1995). "Hairy cell leukaemia, occupation, and smoking". Br. J. Haematol. 91 (1): 154–61. PMID 7577624.