Hairy cell leukemia laboratory tests

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]; Grammar Reviewer: Natalie Harpenau, B.S.[3]

Overview

Laboratory findings consistent with the diagnosis of hairy cell leukemia include abnormal complete blood count, immunohistochemistry, and flow cytometry. The presence of hairy cells with thread-like cytoplasmic extensions on blood smear is a key diagnostic feature among patients with hairy cell leukemia.

Laboratory Findings

Laboratory findings consistent with the diagnosis of hairy cell leukemia include:[1][2][3][4][5]

Complete Blood Count

Blood Smear

Immunohistochemistry and Flow Cytometry

References

  1. Grever, Michael R.; Abdel-Wahab, Omar; Andritsos, Leslie A.; Banerji, Versha; Barrientos, Jacqueline; Blachly, James S.; Call, Timothy G.; Catovsky, Daniel; Dearden, Claire; Demeter, Judit; Else, Monica; Forconi, Francesco; Gozzetti, Alessandro; Ho, Anthony D.; Johnston, James B.; Jones, Jeffrey; Juliusson, Gunnar; Kraut, Eric; Kreitman, Robert J.; Larratt, Loree; Lauria, Francesco; Lozanski, Gerard; Montserrat, Emili; Parikh, Sameer A.; Park, Jae H.; Polliack, Aaron; Quest, Graeme R.; Rai, Kanti R.; Ravandi, Farhad; Robak, Tadeusz; Saven, Alan; Seymour, John F.; Tadmor, Tamar; Tallman, Martin S.; Tam, Constantine; Tiacci, Enrico; Troussard, Xavier; Zent, Clive S.; Zenz, Thorsten; Zinzani, Pier Luigi; Falini, Brunangelo (2017). "Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia". Blood. 129 (5): 553–560. doi:10.1182/blood-2016-01-689422. ISSN 0006-4971.
  2. Frassoldati A, Lamparelli T, Federico M, Annino L, Capnist G, Pagnucco G, Dini E, Resegotti L, Damasio EE, Silingardi V (April 1994). "Hairy cell leukemia: a clinical review based on 725 cases of the Italian Cooperative Group (ICGHCL). Italian Cooperative Group for Hairy Cell Leukemia". Leuk. Lymphoma. 13 (3–4): 307–16. doi:10.3109/10428199409056295. PMID 7519510.
  3. Golomb HM, Catovsky D, Golde DW (November 1978). "Hairy cell leukemia: a clinical review based on 71 cases". Ann. Intern. Med. 89 (5 Pt 1): 677–83. PMID 717940.
  4. Kraut E (June 2011). "Infectious complications in hairy cell leukemia". Leuk. Lymphoma. 52 Suppl 2: 50–2. doi:10.3109/10428194.2011.570819. PMID 21504285.
  5. Westbrook CA, Groopman JE, Golde DW (August 1984). "Hairy cell leukemia. Disease pattern and prognosis". Cancer. 54 (3): 500–6. PMID 6733679.
  6. Somasundaram V, Purohit A, Aggarwal M, Manivannan P, Mishra P, Seth T, Tyagi S, Mahapatra M, Pati HP, Saxena R (2014). "Hairy cell leukemia: A decade long experience of North Indian Hematology Center". Indian J Med Paediatr Oncol. 35 (4): 271–5. doi:10.4103/0971-5851.144988. PMC 4264273. PMID 25538404.
  7. Grever, Michael R.; Abdel-Wahab, Omar; Andritsos, Leslie A.; Banerji, Versha; Barrientos, Jacqueline; Blachly, James S.; Call, Timothy G.; Catovsky, Daniel; Dearden, Claire; Demeter, Judit; Else, Monica; Forconi, Francesco; Gozzetti, Alessandro; Ho, Anthony D.; Johnston, James B.; Jones, Jeffrey; Juliusson, Gunnar; Kraut, Eric; Kreitman, Robert J.; Larratt, Loree; Lauria, Francesco; Lozanski, Gerard; Montserrat, Emili; Parikh, Sameer A.; Park, Jae H.; Polliack, Aaron; Quest, Graeme R.; Rai, Kanti R.; Ravandi, Farhad; Robak, Tadeusz; Saven, Alan; Seymour, John F.; Tadmor, Tamar; Tallman, Martin S.; Tam, Constantine; Tiacci, Enrico; Troussard, Xavier; Zent, Clive S.; Zenz, Thorsten; Zinzani, Pier Luigi; Falini, Brunangelo (2017). "Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia". Blood. 129 (5): 553–560. doi:10.1182/blood-2016-01-689422. ISSN 0006-4971.
  8. Golomb HM (August 1978). "Hairy cell leukemia: an unusual lymphoproliferative disease: a study of 24 patients". Cancer. 42 (2 Suppl): 946–56. PMID 356959.
  9. Bernadou A, Pelletier G, Cadiou M, Giannoni F, James JM, Bilski-Pasquier G (1981). "[Hairy cell leukemia. I.--Clinical, biological and evolutive study on twenty-eight cases (author's transl)]". Sem Hop (in French). 57 (33–36): 1361–5. PMID 6270794.
  10. Sherman, Michael J.; Hanson, Curtis A.; Hoyer, James D. (2011). "An Assessment of the Usefulness of Immunohistochemical Stains in the Diagnosis of Hairy Cell Leukemia". American Journal of Clinical Pathology. 136 (3): 390–399. doi:10.1309/AJCP5GE1PSBMBZTW. ISSN 1943-7722.
  11. Grever, Michael R.; Abdel-Wahab, Omar; Andritsos, Leslie A.; Banerji, Versha; Barrientos, Jacqueline; Blachly, James S.; Call, Timothy G.; Catovsky, Daniel; Dearden, Claire; Demeter, Judit; Else, Monica; Forconi, Francesco; Gozzetti, Alessandro; Ho, Anthony D.; Johnston, James B.; Jones, Jeffrey; Juliusson, Gunnar; Kraut, Eric; Kreitman, Robert J.; Larratt, Loree; Lauria, Francesco; Lozanski, Gerard; Montserrat, Emili; Parikh, Sameer A.; Park, Jae H.; Polliack, Aaron; Quest, Graeme R.; Rai, Kanti R.; Ravandi, Farhad; Robak, Tadeusz; Saven, Alan; Seymour, John F.; Tadmor, Tamar; Tallman, Martin S.; Tam, Constantine; Tiacci, Enrico; Troussard, Xavier; Zent, Clive S.; Zenz, Thorsten; Zinzani, Pier Luigi; Falini, Brunangelo (2017). "Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia". Blood. 129 (5): 553–560. doi:10.1182/blood-2016-01-689422. ISSN 0006-4971.
  12. Venkataraman, Girish; Aguhar, Christine; Kreitman, Robert J.; Yuan, Constance M.; Stetler-Stevenson, Maryalice (2011). "Characteristic CD103 and CD123 Expression Pattern Defines Hairy Cell Leukemia". American Journal of Clinical Pathology. 136 (4): 625–630. doi:10.1309/AJCPKUM9J4IXCWEU. ISSN 1943-7722.
  13. Falini B, Tiacci E, Liso A, Basso K, Sabattini E, Pacini R, Foa R, Pulsoni A, Dalla Favera R, Pileri S (June 2004). "Simple diagnostic assay for hairy cell leukaemia by immunocytochemical detection of annexin A1 (ANXA1)". Lancet. 363 (9424): 1869–70. doi:10.1016/S0140-6736(04)16356-3. PMID 15183626.
  14. Uppal, Guldeep; Ly, Vandi; Wang, Zi-Xuan; Bajaj, Renu; Solomides, Charalambos C.; Banks, Peter M.; Medeiros, L. Jeffrey; Peiper, Stephen C.; Gong, Jerald Z. (2015). "The Utility of BRAF V600E Mutation-Specific Antibody VE1 for the Diagnosis of Hairy Cell Leukemia". American Journal of Clinical Pathology. 143 (1): 120–125. doi:10.1309/AJCPQLQ89VXTVWKN. ISSN 1943-7722.
  15. Andrulis M, Penzel R, Weichert W, von Deimling A, Capper D (December 2012). "Application of a BRAF V600E mutation-specific antibody for the diagnosis of hairy cell leukemia". Am. J. Surg. Pathol. 36 (12): 1796–800. doi:10.1097/PAS.0b013e3182549b50. PMID 22531170.
  16. Wang XJ, Kim A, Li S (2014). "Immunohistochemical analysis using a BRAF V600E mutation specific antibody is highly sensitive and specific for the diagnosis of hairy cell leukemia". Int J Clin Exp Pathol. 7 (7): 4323–8. PMC 4129051. PMID 25120816.

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