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==Overview==
==Overview==
==Future or Investigational Therapies==
* Three immunotoxin drugs are in Phase II trials at the [[NIH]]'s [[National Cancer Institute]] in the U.S.:  [[BL22]]<ref>{{ClinicalTrials|NCT00074048}}</ref>, HA22<ref>{{ClinicalTrials|NCT00462189}}</ref> and LMB-2.<ref>{{ClinicalTrials|NCT00337311}}</ref> 
* All of these protein-based drugs combine part of an anti-B cell antibody with a bacterial toxin to kill the cells on internalization.  BL22 and HA22 attack a common protein called [[CD22]], which is present on hairy cells and healthy B cells.  LMB-2 attacks a protein called [[CD25]], which is not present in HCL-variant, so LMB-2 is only useful for patients with HCL-classic or the Japanese variant.
* All three of these therapies are available only at the National Cancer Institute in Bethesda, Maryland, USA.  While initial results are generally favorable, it is likely to be a number of years before these drugs are available on the market.


==References==
==References==
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Latest revision as of 17:23, 8 April 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Grammar Reviewer: Natalie Harpenau, B.S.[2]

Overview

Future or Investigational Therapies

  • All of these protein-based drugs combine part of an anti-B cell antibody with a bacterial toxin to kill the cells on internalization. BL22 and HA22 attack a common protein called CD22, which is present on hairy cells and healthy B cells. LMB-2 attacks a protein called CD25, which is not present in HCL-variant, so LMB-2 is only useful for patients with HCL-classic or the Japanese variant.
  • All three of these therapies are available only at the National Cancer Institute in Bethesda, Maryland, USA. While initial results are generally favorable, it is likely to be a number of years before these drugs are available on the market.

References


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