Folate deficiency screening

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Screening

Screening for folate deficiency is not routinely recommended. However, early detection can lead to folic acid supplementation, which is a simple treatment of the underlying cause. can reduce the risk of anemia certain conditions such as fetal neural tube defects in newborns.

High risk populations

  • Older people (Age >65)
  • Alcohol abusers
  • Pregnant or lactating women
  • Preterm infants
  • Lower socioeconomic groups
  • Patients with intestinal malabsorption
  • Patients with conditions with increased cell turnover states
  • Patients on special diets, and infants given goats' milk
  • Chronic dialysis patients.

Screening tests

CBC may show increased MCV i.e. MCV > 100fL with or without low hemoglobin.Further testing includes serum folate level (Adults: 2-20 ng/mL). High risk populations are tested for folate deficiency if their CBC is abnormal.

References

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