Folate deficiency risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Several factors may put a person at risk for developing Folate deficiency.These include the presence of congenital defect, malabsorptive disorder and alcohol abuse. Certain medications use are also associated with higher risk for developing Folate deficiency.
Risk Factors
Several factors may put a person at risk for developing Folate deficiency.These include the presence of congenital defect, malabsorptive disorder and alcohol abuse. Certain medications use are also associated with higher risk for developing Folate deficiency.
Common Risk Factors[1][2]
- Common risk factors in the development of Folate deficiency include:
- Low dietary folate intake
- Age >65 years
- Alcoholism
- Pregnant or lactating mothers
- Prematurity
- Intestinal malabsorptive disorders e.g. celiac disease, tropical sprue, jejunal resection, inflammatory bowel diseases.
- Use of drugs e.g. trimethoprim, methotrexate, anticonvulsants, sulfasalazine, or pyrimethamine
- Infantile intake of goats' milk which is low in folate content
- States of increased cell turnover e.g. chronic hemolysis
Less Common Risk Factors
- Less common risk factors in the development of Folate deficiency include:
- Congenital defects in folate absorption and metabolism
- Intake of special diet
- Chronic dialysis
References
- ↑ Shahab-Ferdows, Setareh; Engle-Stone, Reina; Hampel, Daniela; Ndjebayi, Alex O; Nankap, Martin; Brown, Kenneth H; Allen, Lindsay H (2015). "Regional, Socioeconomic, and Dietary Risk Factors for Vitamin B-12 Deficiency Differ from Those for Folate Deficiency in Cameroonian Women and Children". The Journal of Nutrition. 145 (11): 2587–2595. doi:10.3945/jn.115.210195. ISSN 1541-6100.
- ↑ Metz, Jack (1999). "Results: Appropriate use of tests for folate and vitamin B12 deficiency". Australian Prescriber. 22 (1): 16–18. doi:10.18773/austprescr.1999.010. ISSN 0312-8008.