Folate deficiency classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Classification

Folate deficiency can be classified as follows :

Situational

Some situations that increase the need for folate may lead to folate deficiency in the body. These include:

  • hemorrhage
  • kidney dialysis
  • liver disease
  • malabsorption e.g. celiac disease
  • pregnancy and lactation
  • alcohol consumption

Medication

Medications can interfere with folate utilization, including:

  • anticonvulsant medications e.g phenytoin
  • metformin 
  • methotrexate, an anti-cancer drug also used as an anti-inflammatory
  • sulfasalazine, used in Inflammatory bowel syndrome
  • birth control pills

Congenital

  • Defects in folate metabolism
  • Defects in folate absorption

References

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