Ependymoma medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]

Overview

There is no evidence to date that adjuvant chemotherapy, including the use of myeloablative chemotherapy,^[1] improves the outcome for patients with totally resected, nondisseminated ependymoma.^[2]
current treatment approaches do not include chemotherapy as a standard component of primary therapy for children with newly diagnosed ependymomas that are completely resected.

Radiation therapy consisting of 54 gray to 55.8 gray is recommended for children aged 3 years and older who are diagnosed with well-differentiated ependymomas.^[3]
It is not necessary to treat the entire CNS (whole brain and spine) because these tumors usually recur initially at the local site.^[4]^[5]
When possible, patients should be treated in a center experienced with the delivery of highly conformal radiation therapy (including intensity-modulated radiation therapy or charged-particle radiation therapy) to pediatric patients with brain tumors.

↑ Warth J, Desforges JF (1975). "Determinants of intracellular pH in the erythrocyte". Br J Haematol. 29 (3): 369–72. PMID 34-40 Check |pmid= value (help).
↑ Kozlova MV (1975). "[Differences in the responses of taste receptors to organic and inorganic acids with changes in the concentration of bicarbonate in the solution]". Fiziol Zh SSSR Im I M Sechenova. 61 (7): 1000–7. PMID 1293-301 Check |pmid= value (help).
↑ Diewitz M (1975). "[Coronary heart disease and its differential treatment]". Med Welt. 26 (43): 1980–8. PMID 583-90 Check |pmid= value (help).
↑ De Dobbeleer GD, Ledoux-Corbusier MH, Achten GA (1975). "Graft versus host reaction. An ultrastructural study". Arch Dermatol. 111 (12): 1597–902. PMID 972-8 Check |pmid= value (help).
↑ Colwell WM, Simmons DG, Harris JR, Fulp TG, Carrozza JH, Maag TA (1975). "Influence of some physical factors on survival of Marek's disease vaccine virus". Avian Dis. 19 (4): 781–90. PMID 987-93 Check |pmid= value (help).