Ependymoma medical therapy

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Ependymoma Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]

Overview

The predominant therapy for ependymoma is surgical resection. Adjunctive chemoradiation may be required.

Chemotherapy

  • There is no evidence to date that adjuvant chemotherapy, including the use of myeloablative chemotherapy, improves the outcome for patients with totally resected, nondisseminated ependymoma.[1]
  • Current treatment approaches do not include chemotherapy as a standard component of primary therapy for children with newly diagnosed ependymomas that are completely resected.
  • Etoposide may be used in recurrent cases.

Radiation Therapy

  • Radiation therapy consisting of 54 gray to 55.8 gray is recommended for children aged 3 years and older who are diagnosed with well-differentiated ependymomas.[2]
  • It is not necessary to treat the entire CNS (whole brain and spine) because these tumors usually recur initially at the local site.
  • When possible, patients should be treated in a center experienced with the delivery of highly conformal radiation therapy (including intensity-modulated radiation therapy or charged-particle radiation therapy) to pediatric patients with brain tumors.

References


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