Eczema causes: Difference between revisions

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{{Eczema}}
{{Eczema}}
{{CMG}}, {{AE}} [[User:Edzelco|Edzel Lorraine Co, D.M.D., M.D.]]
{{CMG}}, {{AE}} {{EdzelCo}}


==Overview==
==Overview==
[[Eczema]] could be due to a [[genetic]] problem, or a result of the [[adverse effect]] of certain [[medication]].
The [[etiology]] of [[eczema]] is multifactorial and complex. This involves aberrations in [[genetic]] components, [[adverse effect]]s of certain [[medication]]s, and some environmental factors.


==Causes==
==Etiology of Eczema==
*Damage from the [[Enzyme|enzymatic]] activity of [[allergens]] is usually prevented by the body's own [[protease inhibitor]]s, such as, ''[[LEKTI]]'',  produced from the gene ''[[SPINK5]]''.
**[[Netherton’s syndrome]], a [[congenital]] condition presenting with [[erythroderma]], [[food allergy]], [[hay fever]], [[asthma]], and [[urticaria]], results from the [[mutation]] of this [[gene]]. <ref name="pmid11544479">{{cite journal |author=Walley AJ, Chavanas S, Moffatt MF, ''et al'' |title=Gene polymorphism in Netherton and common atopic disease |journal=Nat. Genet. |volume=29 |issue=2 |pages=175–8 |year=2001[[Mutations]] in this gene are known to cause  |pmid=11544479 |doi=10.1038/ng728}}</ref>


*Lack of [[filaggrin]] [[gene]] causes [[dry skin]] and impaired [[skin]] [[barrier]] [[function]]. <ref name=filaggrin>Palmer, C.N. ''et al.'' (2006) Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. ''Nature Genetics''  '''38'''(4), 441-6. PMID 16550169</ref>
===Genetic problem===
 
*Damage from the [[Enzyme|enzymatic]] activity of [[allergens]] is usually prevented by the body's own [[protease inhibitor]]s, such as ''[[LEKTI]]'',  produced from the gene ''[[SPINK5]]''.
*[[Substance P]] and [[Brain-derived neurotrophic factor]] (BDNF) are responsible for the [[pruritic]] sensation in [[eczema]]. <ref name="BBC-blood chemicals">{{cite news |author= |title= 'Blood chemicals link' to eczema -- Scientists have identified two blood chemicals linked to itchy eczema, offering new treatment possibilities. |url= http://news.bbc.co.uk/2/hi/health/6962450.stm |date= 26 August 2007 |publisher=BBC News |accessdate=2007-10-16}}</ref>
*Lack of [[filaggrin]] [[gene]] causes [[dry skin]]. <ref name="pmid16550169">{{cite journal| author=Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP | display-authors=etal| title=Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. | journal=Nat Genet | year= 2006 | volume= 38 | issue= 4 | pages= 441-6 | pmid=16550169 | doi=10.1038/ng1767 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16550169  }} </ref>
 
 
===Common Medications with Eczema as the Adverse Drug Effect===


===Eczema as an Adverse Drug Reaction===
*[[Eczema]] can also be brought about by some adverse effects of [[medications]].
*Below is a list of commonly prescribed medications with [[eczema]] as the common [[adverse drug effect]] '''(Table 1)'''.
*Below is a list of commonly prescribed medications with [[eczema]] as the common [[adverse drug effect]] '''(Table 1)'''.


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|+<big>''' Table 1. More Common types of [[Eczema]].'''
|+<big>''' Table 1. List of [[medications]] with [[eczema]] as its [[adverse effect]].'''
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==References==
==References==
{{reflist|2}}
{{reflist|2}}
[[category:Up to Date]]

Latest revision as of 07:43, 13 November 2023

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Edzel Lorraine Co, DMD, MD[2]

Overview

The etiology of eczema is multifactorial and complex. This involves aberrations in genetic components, adverse effects of certain medications, and some environmental factors.

Etiology of Eczema

Genetic problem

Eczema as an Adverse Drug Reaction


Table 1. List of medications with eczema as its adverse effect.
Medication
Cidofovir
Flurbiprofen
Olaparib
Siltuximab
Sorafenib
Tiagabine

References

  1. Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP; et al. (2006). "Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis". Nat Genet. 38 (4): 441–6. doi:10.1038/ng1767. PMID 16550169.