Differentiating vasculitis from other diseases: Difference between revisions

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! colspan="3" rowspan="4" style="background:#4479BA; color: #FFFFFF;" align="center" |Diseases
! colspan="3" rowspan="4" style="background:#4479BA; color: #FFFFFF;" align="center" |Diseases
| colspan="8" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" |'''Clinical manifestations'''
| colspan="8" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" |'''Clinical manifestations'''
! colspan="7" rowspan="2" |Para-clinical findings
! colspan="8" rowspan="2" |Para-clinical findings
| colspan="1" rowspan="4" style="background:#4479BA; color: #FFFFFF;" align="center" |'''Gold standard'''
| colspan="1" rowspan="4" style="background:#4479BA; color: #FFFFFF;" align="center" |'''Gold standard'''
! rowspan="4" style="background:#4479BA; color: #FFFFFF;" align="center" |Additional findings
! rowspan="4" style="background:#4479BA; color: #FFFFFF;" align="center" |Additional findings
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|-
|-
! colspan="4" |Lab Findings
! colspan="4" |Lab Findings
! colspan="3" style="background:#4479BA; color: #FFFFFF;" |Imaging
! colspan="4" style="background:#4479BA; color: #FFFFFF;" |Imaging
|-
|-
! style="background:#4479BA; color: #FFFFFF;" align="center" |Headache
! style="background:#4479BA; color: #FFFFFF;" align="center" |Headache
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! style="background:#4479BA; color: #FFFFFF;" align="center" |ESR
! style="background:#4479BA; color: #FFFFFF;" align="center" |ESR
! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
! style="background:#4479BA; color: #FFFFFF;" align="center" |X-ray
! style="background:#4479BA; color: #FFFFFF;" align="center" |CT scan
! style="background:#4479BA; color: #FFFFFF;" align="center" |CT scan
! style="background:#4479BA; color: #FFFFFF;" align="center" |Angiography
! style="background:#4479BA; color: #FFFFFF;" align="center" |Angiography
! style="background:#4479BA; color: #FFFFFF;" align="center" |Ultrasound
!Other
|-
|-
! rowspan="9" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Large-Vessel Vasculitis
! rowspan="9" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Large-Vessel Vasculitis
! colspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Takayasu arteritis]]
! colspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Takayasu arteritis]]<ref name="pmid23626437">{{cite journal| author=Vaideeswar P, Deshpande JR| title=Pathology of Takayasu arteritis: A brief review. | journal=Ann Pediatr Cardiol | year= 2013 | volume= 6 | issue= 1 | pages= 52-8 | pmid=23626437 | doi=10.4103/0974-2069.107235 | pmc=3634248 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23626437  }}</ref>
!
!+
!
!+/-
!
!+
!
!+
!
!+
!
!+
!
!+/-
!
!+/-
!
![[ESR]]
!
![[Leukocytosis]], [[Anemia]]
!
!↑
!
![[CRP]]
!
![[Aneurysm|Aneurysmal dilatation]] of the [[aorta]]
!
![[Blood vessel]] [[stenosis]]
!
!Circumferential thickening of the [[arterial]] wall (Macaroni sign)
!
![[PET scan|PET-scan]], [[Cardiac]] [[CT]]
!
![[Arteriography]]
![[Coronary aneurysm]]
|-
|-
! colspan="2" |[[Giant cell arteritis]]
! colspan="2" |[[Giant cell arteritis]]
!
!
!
!
!
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!
!
|-
|-
! rowspan="3" |Neurological disease
! rowspan="3" |[[Neurological disease]]
![[Cerebral aneurysm]]
![[Cerebral aneurysm]]
!
!
!
!
!
Line 100: Line 104:
|-
|-
![[Neurofibromatosis type 1]]
![[Neurofibromatosis type 1]]
!
!
!
!
!
Line 119: Line 124:
|-
|-
![[Neurofibromatosis type 2]]
![[Neurofibromatosis type 2]]
!
!
!
!
!
Line 137: Line 143:
!
!
|-
|-
! rowspan="4" |Systemic disease
! rowspan="4" |[[Systemic disease]]
![[Fibromuscular dysplasia]]
![[Fibromuscular dysplasia]]
!
!
!
!
!
Line 158: Line 165:
|-
|-
![[Ehlers-Danlos syndrome]]
![[Ehlers-Danlos syndrome]]
!
!
!
!
!
Line 177: Line 185:
|-
|-
![[Polymyalgia rheumatica|Polymyalgia rheumatica (PMR)]]
![[Polymyalgia rheumatica|Polymyalgia rheumatica (PMR)]]
!
!
!
!
!
Line 196: Line 205:
|-
|-
![[Amyloidosis]]
![[Amyloidosis]]
!
!
!
!
!
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! rowspan="18" |Medium-Vessel Vasculitis
! rowspan="18" |Medium-Vessel Vasculitis
! colspan="2" |[[Polyarteritis nodosa]]
! colspan="2" |[[Polyarteritis nodosa]]
!
!
!
!
!
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|-
|-
! colspan="2" |[[Hepatitis B virus]]-associated [[polyarteritis nodosa]]
! colspan="2" |[[Hepatitis B virus]]-associated [[polyarteritis nodosa]]
!
!
!
!
!
Line 254: Line 266:
|-
|-
! colspan="2" |[[Kawasaki disease]]
! colspan="2" |[[Kawasaki disease]]
!
!
!
!
!
Line 272: Line 285:
!
!
|-
|-
! rowspan="10" |Infectious disease
! rowspan="10" |[[Infectious disease]]
!Parvovirus B19 infection
![[Parvovirus B19 infection]]
!
!
!
!
!
Line 292: Line 306:
!
!
|-
|-
!Scarlet fever
![[Scarlet fever]]
!
!
!
!
!
Line 311: Line 326:
!
!
|-
|-
!Toxic shock syndrome
![[Toxic shock syndrome]]
!
!
!
!
!
Line 330: Line 346:
!
!
|-
|-
!Mononucleosis
![[Mononucleosis]]
!
!
!
!
!
Line 349: Line 366:
!
!
|-
|-
!Leptospirosis
![[Leptospirosis]]
!
!
!
!
!
Line 368: Line 386:
!
!
|-
|-
!Lyme Disease
![[Lyme disease|Lyme Disease]]
!
!
!
!
!
Line 387: Line 406:
!
!
|-
|-
!Measles
![[Measles]]
!
!
!
!
!
Line 406: Line 426:
!
!
|-
|-
!Pediatric Rocky Mountain Spotted Fever
![[Rocky Mountain Spotted Fever]]
!
!
!
!
!
Line 425: Line 446:
!
!
|-
|-
!Staphylococcal Scalded Skin Syndrome
![[Staphylococcal scalded skin syndrome|Staphylococcal Scalded Skin Syndrome]]
!
!
!
!
!
Line 444: Line 466:
!
!
|-
|-
!Toxic Epidermal Necrolysis
![[Toxic Epidermal Necrolysis]]
!
!
!
!
!
Line 463: Line 486:
!
!
|-
|-
! rowspan="3" |Cardiovascular disease
! rowspan="3" |[[Cardiovascular disease]]
!Atrial Myxoma
![[Atrial Myxoma]]
!
!
!
!
!
Line 483: Line 507:
!
!
|-
|-
!Cholesterol Embolism
![[Cholesterol Embolism]]
!
!
!
!
!
Line 502: Line 527:
!
!
|-
|-
!Segmental arterial mediolysis
![[Segmental arteries|Segmental arterial]] mediolysis
!
!
!
!
!
Line 521: Line 547:
!
!
|-
|-
! rowspan="2" |Systemic disease
! rowspan="2" |[[Systemic disease]]
!Antiphospholipid Syndrome
![[Antiphospholipid syndrome|Antiphospholipid Syndrome]]
!
!
!
!
!
Line 541: Line 568:
!
!
|-
|-
!Juvenile Idiopathic Arthritis
![[Juvenile Idiopathic Arthritis]]
!
!
!
!
!
Line 561: Line 589:
|-
|-
! rowspan="33" |Small-Vessel Vasculitis
! rowspan="33" |Small-Vessel Vasculitis
! rowspan="4" |ANCA-associated vasculitis
! rowspan="4" |[[ANCA-associated vasculitis]]
![[Microscopic polyangiitis]]
![[Microscopic polyangiitis]]
!
!
!
!
!
Line 582: Line 611:
|-
|-
![[Granulomatosis with polyangiitis|Granulomatosis with polyangiitis (Wegener’s)]]
![[Granulomatosis with polyangiitis|Granulomatosis with polyangiitis (Wegener’s)]]
!
!
!
!
!
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|-
|-
![[Eosinophilic granulomatosis with polyangiitis|Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)]]
![[Eosinophilic granulomatosis with polyangiitis|Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)]]
!
!
!
!
!
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|-
|-
![[Hydralazine]]-associated [[ANCA-associated vasculitis]]
![[Hydralazine]]-associated [[ANCA-associated vasculitis]]
!
!
!
!
!
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!
!
|-
|-
! rowspan="5" |Immune complex small-vessel vasculitis
! rowspan="5" |[[Immune complexes|Immune complex]] small-vessel vasculitis
![[Goodpasture disease|Anti-glomerular basement membrane disease]]
![[Goodpasture disease|Anti-glomerular basement membrane disease]]
!
!
!
!
!
Line 659: Line 692:
|-
|-
![[Cryoglobulinemia|Cryoglobulinemic vasculitis]]
![[Cryoglobulinemia|Cryoglobulinemic vasculitis]]
!
!
!
!
!
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|-
|-
! [[Hepatitis C virus]]-associated [[Cryoglobulinemia|cryoglobulinemic vasculitis]]
! [[Hepatitis C virus]]-associated [[Cryoglobulinemia|cryoglobulinemic vasculitis]]
!
!
!
!
!
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|-
|-
![[Henoch-Schönlein purpura|IgA vasculitis (Henoch-Schönlein purpura)]]
![[Henoch-Schönlein purpura|IgA vasculitis (Henoch-Schönlein purpura)]]
!
!
!
!
!
Line 716: Line 752:
|-
|-
![[Hypocomplementemia|Hypocomplementemic urticarial vasculitis (anti-C1q vasculitis)]]
![[Hypocomplementemia|Hypocomplementemic urticarial vasculitis (anti-C1q vasculitis)]]
!
!
!
!
!
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!
!
|-
|-
!Gastrointestinal disease
![[Gastrointestinal diseases|Gastrointestinal disease]]
![[Acute mesenteric ischemia]]
![[Acute mesenteric ischemia]]
!
!
!
!
!
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!
!
|-
|-
! rowspan="2" |Cardiovascular disease
! rowspan="2" |[[Cardiovascular diseases|Cardiovascular disease]]
!Infective Endocarditis
![[Infective Endocarditis]]
!
!
!
!
!
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!
!
|-
|-
!Leukocytoclastic Vasculitis
![[Leukocytoclastic vasculitis|Leukocytoclastic Vasculitis]]
!
!
!
!
!
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!
!
|-
|-
! rowspan="6" |Pulmonary disease
! rowspan="6" |[[Pulmonary disease]]
!Langerhans Cell Histiocytosis
![[Langerhans Cell Histiocytosis]]
!
!
!
!
!
Line 813: Line 854:
!
!
|-
|-
!Lung Abscess
![[Lung abscess|Lung Abscess]]
!
!
!
!
!
Line 832: Line 874:
!
!
|-
|-
!Non-Small Cell Lung Cancer
![[Non small cell lung cancer|Non-Small Cell Lung Cancer]]
!
!
!
!
!
Line 851: Line 894:
!
!
|-
|-
!Small Cell Lung Cancer
![[Small cell lung cancer|Small Cell Lung Cancer]]
!
!
!
!
!
Line 870: Line 914:
!
!
|-
|-
!Asthma
![[Asthma]]
!
!
!
!
!
Line 889: Line 934:
!
!
|-
|-
!Pulmonary Infarction
![[Pulmonary Infarction]]
!
!
!
!
!
Line 908: Line 954:
!
!
|-
|-
!Renal disease
![[Renal disease]]
!Acute Poststreptococcal Glomerulonephritis
![[Acute poststreptococcal glomerulonephritis|Acute Poststreptococcal Glomerulonephritis]]
!
!
!
!
!
Line 928: Line 975:
!
!
|-
|-
! rowspan="9" |Hematologic disease
! rowspan="9" |[[Hematologic disease]]
!Hemolytic-Uremic Syndrome
![[Hemolytic-uremic syndrome|Hemolytic-Uremic Syndrome]]
!
!
!
!
!
Line 948: Line 996:
!
!
|-
|-
!Chronic Lymphocytic Leukemia (CLL)
![[Chronic Lymphocytic Leukemia|Chronic Lymphocytic Leukemia (CLL)]]
!
!
!
!
!
Line 967: Line 1,016:
!
!
|-
|-
!Multiple Myeloma
![[Multiple myeloma|Multiple Myeloma]]
!
!
!
!
!
Line 986: Line 1,036:
!
!
|-
|-
!Hypereosinophilic Syndrome
![[Hypereosinophilic syndrome|Hypereosinophilic Syndrome]]
!
!
!
!
!
Line 1,005: Line 1,056:
!
!
|-
|-
!Non-Hodgkin Lymphoma
![[Non-Hodgkin lymphoma|Non-Hodgkin Lymphoma]]
!
!
!
!
!
Line 1,024: Line 1,076:
!
!
|-
|-
!Serum Sickness
![[Serum sickness|Serum Sickness]]
!
!
!
!
!
Line 1,043: Line 1,096:
!
!
|-
|-
!Disseminated Intravascular Coagulation
![[Disseminated intravascular coagulation|Disseminated Intravascular Coagulation]]
!
!
!
!
!
Line 1,062: Line 1,116:
!
!
|-
|-
!Idiopathic Thrombocytopenic Purpura
![[Idiopathic thrombocytopenic purpura|Idiopathic Thrombocytopenic Purpura]]
!
!
!
!
!
Line 1,082: Line 1,137:
|-
|-
![[B cell lymphoproliferative disease|B cell lymphoproliferative disorder]]
![[B cell lymphoproliferative disease|B cell lymphoproliferative disorder]]
!
!
!
!
!
Line 1,100: Line 1,156:
!
!
|-
|-
! rowspan="5" |Systemic disease
! rowspan="5" |[[Systemic disease]]
!Sarcoidosis
![[Sarcoidosis]]
!
!
!
!
!
Line 1,120: Line 1,177:
!
!
|-
|-
!Legionella Infection
![[Legionella Infections|Legionella Infection]]
!
!
!
!
!
Line 1,140: Line 1,198:
|-
|-
![[Systemic lupus erythematosus]]
![[Systemic lupus erythematosus]]
!
!
!
!
!
Line 1,159: Line 1,218:
|-
|-
![[Rheumatoid arthritis]]
![[Rheumatoid arthritis]]
!
!
!
!
!
Line 1,178: Line 1,238:
|-
|-
![[Relapsing polychondritis]]
![[Relapsing polychondritis]]
!
!
!
!
!
Line 1,198: Line 1,259:
! rowspan="5" |Variable-vessel vasculitis
! rowspan="5" |Variable-vessel vasculitis
! colspan="2" |[[Behçet's disease|Behçet’s syndrome]]
! colspan="2" |[[Behçet's disease|Behçet’s syndrome]]
!
!
!
!
!
Line 1,217: Line 1,279:
|-
|-
! colspan="2" |[[Cogan syndrome|Cogan's syndrome]]
! colspan="2" |[[Cogan syndrome|Cogan's syndrome]]
!
!
!
!
!
Line 1,235: Line 1,298:
!
!
|-
|-
! rowspan="3" |Gastrointestinal disease
! rowspan="3" |[[Gastrointestinal diseases|Gastrointestinal disease]]
!Inflammatory Bowel Disease
![[Inflammatory bowel disease|Inflammatory Bowel Disease]]
!
!
!
!
!
Line 1,255: Line 1,319:
!
!
|-
|-
!Whipple's disease
![[Whipple's disease]]
!
!
!
!
!
Line 1,274: Line 1,339:
!
!
|-
|-
!Sjögren's syndrome
![[Sjögren's syndrome]]
!
!
!
!
!
Line 1,295: Line 1,361:
! rowspan="6" |Single-organ vasculitis
! rowspan="6" |Single-organ vasculitis
! colspan="2" |Primary [[central nervous system]] [[vasculitis]]
! colspan="2" |Primary [[central nervous system]] [[vasculitis]]
!
!
!
!
!
Line 1,313: Line 1,380:
!
!
|-
|-
! rowspan="3" |Infectious disease
! rowspan="3" |[[Infectious disease]]
!Aspergillosis
![[Aspergillosis]]
!
!
!
!
!
Line 1,333: Line 1,401:
!
!
|-
|-
!Histoplasmosis
![[Histoplasmosis]]
!
!
!
!
!
Line 1,352: Line 1,421:
!
!
|-
|-
!Herpes Simplex Encephalitis
![[Herpes Simplex Encephalitis]]
!
!
!
!
!
Line 1,371: Line 1,441:
!
!
|-
|-
! rowspan="2" |Systemic disease
! rowspan="2" |[[Systemic diseases|Systemic disease]]
!Eclampsia
![[Eclampsia]]
!
!
!
!
!
Line 1,391: Line 1,462:
!
!
|-
|-
!Fibromuscular Dysplasia
![[Fibromuscular dysplasia|Fibromuscular Dysplasia]]
!
!
!
!
!

Revision as of 13:51, 22 March 2018

Vasculitis

Overview

Classification

Large-sized vessel vasculitis
Takayasu's Arteritis
Temporal Arteritis
Medium-sized vessel vasculitis
Kawasaki's Disease
Polyarteritis Nodosa
Small-sized vessel vasculitis
Churg-Strauss Syndrome
Cutaneous leukocytoclastic vasculitis
Essential cryoglobulinemic vasculitis
Henoch-Schonlein Purpura
Microscopic polyangiitis
Wegener's Granulomatosis
Variable-sized vessel vasculitis
Sjogren syndrome
Cogan syndrome
Single organ vasculitis
Primary central nervous system angiitis

Causes

Differential Diagnosis

gsEditor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

Overview

Differential Diagnosis

Abbreviations: ABG= Arterial blood gas, ANP= Atrial natriuretic peptide, BNP= Brain natriuretic peptide, CBC= Complete blood count, COPD= Chronic obstructive pulmonary disease, CRP= C-reactive protein, CT= Computed tomography, CXR= Chest X-ray, DVT= Deep vein thrombosis, ESR= Erythrocyte sedimentation rate, HRCT= High Resolution CT, IgE= Immunoglobulin E, LDH= Lactate dehydrogenase, PCWP= Pulmonary capillary wedge pressure.

Diseases Clinical manifestations Para-clinical findings Gold standard Additional findings
Symptoms Physical examination
Lab Findings Imaging
Headache Fever Weight loss Arthralgia Claudication Bruit HTN Focal neurological disorder Biomarker CBC ESR Other CT scan Angiography Ultrasound Other
Large-Vessel Vasculitis Takayasu arteritis[1] + +/- + + + + +/- +/- ESR Leukocytosis, Anemia ↑ CRP Aneurysmal dilatation of the aorta Blood vessel stenosis Circumferential thickening of the arterial wall (Macaroni sign) PET-scan, Cardiac CT Arteriography Coronary aneurysm
Giant cell arteritis
Neurological disease Cerebral aneurysm
Neurofibromatosis type 1
Neurofibromatosis type 2
Systemic disease Fibromuscular dysplasia
Ehlers-Danlos syndrome
Polymyalgia rheumatica (PMR)
Amyloidosis
Medium-Vessel Vasculitis Polyarteritis nodosa
Hepatitis B virus-associated polyarteritis nodosa
Kawasaki disease
Infectious disease Parvovirus B19 infection
Scarlet fever
Toxic shock syndrome
Mononucleosis
Leptospirosis
Lyme Disease
Measles
Rocky Mountain Spotted Fever
Staphylococcal Scalded Skin Syndrome
Toxic Epidermal Necrolysis
Cardiovascular disease Atrial Myxoma
Cholesterol Embolism
Segmental arterial mediolysis
Systemic disease Antiphospholipid Syndrome
Juvenile Idiopathic Arthritis
Small-Vessel Vasculitis ANCA-associated vasculitis Microscopic polyangiitis
Granulomatosis with polyangiitis (Wegener’s)
Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)
Hydralazine-associated ANCA-associated vasculitis
Immune complex small-vessel vasculitis Anti-glomerular basement membrane disease
Cryoglobulinemic vasculitis
 Hepatitis C virus-associated cryoglobulinemic vasculitis
IgA vasculitis (Henoch-Schönlein purpura)
Hypocomplementemic urticarial vasculitis (anti-C1q vasculitis)
Gastrointestinal disease Acute mesenteric ischemia
Cardiovascular disease Infective Endocarditis
Leukocytoclastic Vasculitis
Pulmonary disease Langerhans Cell Histiocytosis
Lung Abscess
Non-Small Cell Lung Cancer
Small Cell Lung Cancer
Asthma
Pulmonary Infarction
Renal disease Acute Poststreptococcal Glomerulonephritis
Hematologic disease Hemolytic-Uremic Syndrome
Chronic Lymphocytic Leukemia (CLL)
Multiple Myeloma
Hypereosinophilic Syndrome
Non-Hodgkin Lymphoma
Serum Sickness
Disseminated Intravascular Coagulation
Idiopathic Thrombocytopenic Purpura
B cell lymphoproliferative disorder
Systemic disease Sarcoidosis
Legionella Infection
Systemic lupus erythematosus
Rheumatoid arthritis
Relapsing polychondritis
Variable-vessel vasculitis Behçet’s syndrome
Cogan's syndrome
Gastrointestinal disease Inflammatory Bowel Disease
Whipple's disease
Sjögren's syndrome
Single-organ vasculitis Primary central nervous system vasculitis
Infectious disease Aspergillosis
Histoplasmosis
Herpes Simplex Encephalitis
Systemic disease Eclampsia
Fibromuscular Dysplasia

References

  1. ↑ Vaideeswar P, Deshpande JR (2013). "Pathology of Takayasu arteritis: A brief review". Ann Pediatr Cardiol. 6 (1): 52–8. doi:10.4103/0974-2069.107235. PMC 3634248. PMID 23626437.

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