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'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''
__NOTOC__
{{DiseaseDisorder infobox |
{{DiseaseDisorder infobox |
   Name          = {{PAGENAME}} |
   Name          = {{PAGENAME}} |
   Image          = Pulmonary cryptococcosis (2) Alcian blue-PAS.jpg |
   Image          = Pulmonary cryptococcosis (2) Alcian blue-PAS.jpg |
   Caption        = Histopathological image of pulmonary cryptococcosis in an immunocompromised host. Alcian blue-PAS stain. |
   Caption        = Pulmonary cryptococcosis in an immunocompromised host, source: wikiwand.com|
  ICD10          = {{ICD10|B|45||b|35}} |
  ICD9          = {{ICD9|117.5}} |
  ICDO          = |
  OMIM          = |
  DiseasesDB    = 3213 |
  MedlinePlus    = |
  eMedicineSubj  = med |
  eMedicineTopic = 482 |
  MeshID        = D003453 |
}}
}}
{{Cryptococcosis}}
{{Cryptococcosis}}
{{About1|Cryptococcus neoformans}}


{{CMG}}
'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''


==Overview==
{{CMG}}; {{AE}} {{SSK}}, {{YD}}
'''Cryptococcosis''' is an infection acquired by inhalation of soil contaminated with the encapsulated yeast ([[fungus]]) [[Cryptococcus neoformans]].


== Etiology and Incidence ==
{{SK}} Busse-Buschke Disease; Torulosis; European Blastomycosis; Cryptococcal Meningitis; Cryptococcal Pneumonia
Cryptococcosis is a defining opportunistic infection for [[AIDS]], although patients with [[Hodgkin's]] or other [[lymphomas]] or [[sarcoidosis]] or those receiving long-term [[corticosteroid]] therapy are also at increased risk.


Distribution is worldwide. The prevalence of cryptococcosis has been increasing over the past 20 years for many reasons, including the increase in indicence of AIDS and the expanded use of immunosuppressive drugs.
==[[Cryptococcosis overview|Overview]]==


In humans, ''C. neoformans'' causes three types of infections:
==[[Cryptococcosis historical perspective|Historical Perspective]]==
* Wound or [[cutaneous]] cryptococcosis
* [[Pulmonary]] cryptococcosis, and
* Cryptococcal [[meningitis]].
Cryptococcal meningitis (infection of the brain) is believed to result from dissemination of the fungus from either an observed or unappreciated pulmonary infection.  ''[[Cryptococcus gattii]]'' causes infections in immunocompetent people (those having a functioning [[immune system]]), but ''C. neoformans v. grubii'', and ''v. neoformans'' usually only cause clinically evident infections in persons who have some form of defect in their immune systems (immunocompromised persons).  People who have defects in their [[cell-mediated immunity]], for example, people with [[AIDS]], are especially susceptible to disseminated cryptococcosis. Cryptococcosis is often fatal, especially if untreated.


== Diagnosis ==
==[[Cryptococcosis classification|Classification]]==


Symptoms include chest pain, dry cough, swelling of abdomen, headache, blurred vision and confusion. Although symptoms may not be able to be detected.
==[[Cryptococcosis pathophysiology|Pathophysiology]]==


Detection of cryptococcal [[antigen]] (capsular material) by [[Microbiological culture|culture]] of [[Cerebrospinal fluid|CSF]], [[sputum]] and [[urine]] provides definitive diagnosis. Blood cultures may be positive in heavy infections.
==[[Cryptococcosis causes|Causes]]==


=== Cerebrum: Cryptococcosis (PAS stain) ===
==[[Cryptococcosis differential diagnosis|Differentiating Cryptococcosis from other Diseases]]==


<youtube v=ZG0AcmtBLe4/>
==[[Cryptococcosis epidemiology and demographics|Epidemiology and Demographics]]==


== Treatment ==
==[[Cryptococcosis risk factors|Risk Factors]]==


The standard regimen of treatment in non-AIDS patients [[intravenous]] [[Amphotericin B]] combined with [[Wiktionary:oral|oral]] [[flucytosine]].
==[[Cryptococcosis screening|Screening]]==


AIDS patients often have a reduced response to Amphotericin B and flucytosine, therefore after initial treatment as above, oral [[fluconazole]] can be used.
==[[Cryptococcosis Natural History, Complications and Prognosis|Natural History, Complications and Prognosis]]==


==External links==
==Diagnosis==
* [http://www.merck.com/mrkshared/CVMHighLight?file=/mrkshared/mmanual/section13/chapter158/158g.jsp%3Fregion%3Dmerckcom&word=Cryptococcosis&domain=www.merck.com#hl_anchor The Merck Manual]
[[Cryptococcosis history and symptoms|History and Symptoms]] | [[Cryptococcosis physical examination|Physical Examination]] | [[Cryptococcosis laboratory tests|Laboratory Findings]] | [[Cryptococcosis chest x ray|Chest X Ray]] | [[Cryptococcosis CT|CT]] | [[Cryptococcosis MRI|MRI]] | [[Cryptococcosis other imaging findings|Other Imaging Findings]] | [[Cryptococcosis other diagnostic studies|Other Diagnostic Studies]]
* [http://www.healthatoz.com/healthatoz/Atoz/ency/cryptococcosis.jsp Health AtoZ]
 
* {{WhoNamedIt|synd|1793}}
==Treatment==
* [http://www.youtube.com/watch?v=ZG0AcmtBLe4 See pathology video with commentary of brain tissue infested by cryptoccocus neoformans]
[[Cryptococcosis medical therapy|Medical Therapy]] | [[Cryptococcosis surgery|Surgery]] | [[Cryptococcosis primary prevention|Primary Prevention]]  | [[Cryptococcosis secondary prevention|Secondary Prevention]] | [[Cryptococcosis cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Cryptococcosis future or investigational therapies|Future or Investigational Therapies]]
 
==Case Studies==
[[Cryptococcosis case study one|Case #1]]


{{Mycoses}}
{{Mycoses}}
[[Category:Fungal diseases]]
[[Category:Overview complete]]
[[ca:Criptococcosi]]
[[fr:Cryptococcose]]
[[pl:Kryptokokoza]]
[[pt:Criptococose]]


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[[Category:Pulmonology]]
[[Category:Neurology]]
[[Category:Dermatology]]

Latest revision as of 21:10, 29 July 2020

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Cryptococcosis Microchapters

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Overview

Historical Perspective

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This page is about clinical aspects of the disease.  For microbiologic aspects of the causative organism(s), see Cryptococcus neoformans.

For patient information click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Serge Korjian M.D., Yazan Daaboul, M.D.

Synonyms and keywords: Busse-Buschke Disease; Torulosis; European Blastomycosis; Cryptococcal Meningitis; Cryptococcal Pneumonia

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Cryptococcosis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | Chest X Ray | CT | MRI | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

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