Carcinoma of the penis pathophysiology
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Carcinoma of the penis Microchapters |
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Editor(s)-in-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753; Joel Gelman, M.D. [2], Director of the Center for Reconstructive Urology and Associate Clinical Professor in the Department of Urology at the University of California,Irvine
Overview
On gross pathology, scaly patches or nodules, erythematous, and ulceration are characteristic findings of carcinoma of the penis.
Pathogenesis
- Penile cancer arises from precursor lesions, which generally progress from low-grade to high-grade lesions.
- For HPV related penile cancers this sequence is as follows:[1]
- A. Squamous hyperplasia
- B. Low-grade penile intraepithelial neoplasia (PIN)
- C. High-grade PIN (carcinoma in situ—Bowen's disease, Erythroplasia of Queyrat and bowenoid papulosis (BP))
- D. Invasive carcinoma of the penis
Gross Pathology
- Scaly patches or nodules
- Usually erythematous
- Ulceration
Microscopic Pathology
References
- ↑ Bleeker MC, Heideman DA, Snijders PJ, Horenblas S, Dillner J, Meijer CJ (2009). "Penile cancer: epidemiology, pathogenesis and prevention". World J Urol. 27 (2): 141–50. doi:10.1007/s00345-008-0302-z. PMID 18607597.