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{{Infobox_gene}}
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'''Dual specificity protein phosphatase CDC14A''' is an [[enzyme]] that in humans is encoded by the ''CDC14A'' [[gene]].<ref name="pmid9367992">{{cite journal | vauthors = Li L, Ernsting BR, Wishart MJ, Lohse DL, Dixon JE | title = A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast | journal = J Biol Chem | volume = 272 | issue = 47 | pages = 29403–6 |date=December 1997 | pmid = 9367992 | pmc =  | doi =10.1074/jbc.272.47.29403 }}</ref><ref name="pmid10409437">{{cite journal | vauthors = Wong AK, Chen Y, Lian L, Ha PC, Petersen K, Laity K, Carillo A, Emerson M, Heichman K, Gupte J, Tavtigian SV, Teng DH | title = Genomic structure, chromosomal location, and mutation analysis of the human CDC14A gene | journal = Genomics | volume = 59 | issue = 2 | pages = 248–51 |date=September 1999 | pmid = 10409437 | pmc =  | doi = 10.1006/geno.1999.5863 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDC14A CDC14 cell division cycle 14 homolog A (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8556| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CDC14 cell division cycle 14 homolog A (S. cerevisiae)
| HGNCid = 1718
| Symbol = CDC14A
| AltSymbols =; Cdc14A1; Cdc14A2; cdc14; hCDC14
| OMIM = 603504
| ECnumber =
| Homologene = 89026
| MGIid = 2442676
  | GeneAtlas_image1 = PBB_GE_CDC14A_210743_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CDC14A_210742_at_tn.png
  | Function = {{GNF_GO|id=GO:0004725 |text = protein tyrosine phosphatase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008138 |text = protein tyrosine/serine/threonine phosphatase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006470 |text = protein amino acid dephosphorylation}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0051301 |text = cell division}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8556
    | Hs_Ensembl = ENSG00000079335
    | Hs_RefseqProtein = NP_003663
    | Hs_RefseqmRNA = NM_003672
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 100590540
    | Hs_GenLoc_end = 100758420
    | Hs_Uniprot = Q9UNH5
    | Mm_EntrezGene = 229776
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = XM_149387
    | Mm_RefseqProtein = XP_149387
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''CDC14 cell division cycle 14 homolog A (S. cerevisiae)''', also known as '''CDC14A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CDC14A CDC14 cell division cycle 14 homolog A (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8556| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: CDC14A CDC14 cell division cycle 14 homolog A (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8556| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.<ref name="entrez" />
}}
}}
==Interactions==
CDC14A has been shown to [[Protein-protein interaction|interact]] with [[P53]].<ref name=pmid10644693>{{cite journal |last=Li |first=L |author2=Ljungman M|author3=Dixon J E |date=January 2000  |title=The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53 |journal=J. Biol. Chem. |volume=275 |issue=4 |pages=2410–4 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10644693 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.275.4.2410 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CDC14A}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Li L, Ernsting BR, Wishart MJ, ''et al.'' |title=A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast. |journal=J. Biol. Chem. |volume=272 |issue= 47 |pages= 29403-6 |year= 1997 |pmid= 9367992 |doi=  }}
*{{cite journal  | vauthors=Li L, Ljungman M, Dixon JE |title=The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53 |journal=J. Biol. Chem. |volume=275 |issue= 4 |pages= 2410–4 |year= 2000 |pmid= 10644693 |doi=10.1074/jbc.275.4.2410 }}
*{{cite journal  | author=Wong AK, Chen Y, Lian L, ''et al.'' |title=Genomic structure, chromosomal location, and mutation analysis of the human CDC14A gene. |journal=Genomics |volume=59 |issue= 2 |pages= 248-51 |year= 1999 |pmid= 10409437 |doi= 10.1006/geno.1999.5863 }}
*{{cite journal  | vauthors=Bembenek J, Yu H |title=Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a |journal=J. Biol. Chem. |volume=276 |issue= 51 |pages= 48237–42 |year= 2002 |pmid= 11598127 |doi= 10.1074/jbc.M108126200 }}
*{{cite journal  | author=Li L, Ljungman M, Dixon JE |title=The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53. |journal=J. Biol. Chem. |volume=275 |issue= 4 |pages= 2410-4 |year= 2000 |pmid= 10644693 |doi=  }}
*{{cite journal  | vauthors=Mailand N, Lukas C, Kaiser BK |title=Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation |journal=Nat. Cell Biol. |volume=4 |issue= 4 |pages= 317–22 |year= 2002 |pmid= 11901424 |doi= 10.1038/ncb777 |display-authors=etal}}
*{{cite journal  | author=Bembenek J, Yu H |title=Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a. |journal=J. Biol. Chem. |volume=276 |issue= 51 |pages= 48237-42 |year= 2002 |pmid= 11598127 |doi= 10.1074/jbc.M108126200 }}
*{{cite journal  | vauthors=Kaiser BK, Zimmerman ZA, Charbonneau H, Jackson PK |title=Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase |journal=Mol. Biol. Cell |volume=13 |issue= 7 |pages= 2289–300 |year= 2003 |pmid= 12134069 |doi= 10.1091/mbc.01-11-0535 | pmc=117313 }}
*{{cite journal  | author=Mailand N, Lukas C, Kaiser BK, ''et al.'' |title=Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation. |journal=Nat. Cell Biol. |volume=4 |issue= 4 |pages= 317-22 |year= 2002 |pmid= 11901424 |doi= 10.1038/ncb777 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
*{{cite journal  | author=Kaiser BK, Zimmerman ZA, Charbonneau H, Jackson PK |title=Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase. |journal=Mol. Biol. Cell |volume=13 |issue= 7 |pages= 2289-300 |year= 2003 |pmid= 12134069 |doi= 10.1091/mbc.01-11-0535 }}
*{{cite journal  | vauthors=Gruneberg U, Neef R, Honda R |title=Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2 |journal=J. Cell Biol. |volume=166 |issue= 2 |pages= 167–72 |year= 2004 |pmid= 15263015 |doi= 10.1083/jcb.200403084 | pmc=2172317 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gruneberg U, Neef R, Honda R, ''et al.'' |title=Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2. |journal=J. Cell Biol. |volume=166 |issue= 2 |pages= 167-72 |year= 2004 |pmid= 15263015 |doi= 10.1083/jcb.200403084 }}
*{{cite journal  | vauthors=Vázquez-Novelle MD, Esteban V, Bueno A, Sacristán MP |title=Functional homology among human and fission yeast Cdc14 phosphatases |journal=J. Biol. Chem. |volume=280 |issue= 32 |pages= 29144–50 |year= 2005 |pmid= 15911625 |doi= 10.1074/jbc.M413328200 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Zhao H, Wang Q, Zhang H |title=UXT is a novel centrosomal protein essential for cell viability |journal=Mol. Biol. Cell |volume=16 |issue= 12 |pages= 5857–65 |year= 2006 |pmid= 16221885 |doi= 10.1091/mbc.E05-08-0705 | pmc=1289427 |display-authors=etal}}
*{{cite journal  | author=Vázquez-Novelle MD, Esteban V, Bueno A, Sacristán MP |title=Functional homology among human and fission yeast Cdc14 phosphatases. |journal=J. Biol. Chem. |volume=280 |issue= 32 |pages= 29144-50 |year= 2005 |pmid= 15911625 |doi= 10.1074/jbc.M413328200 }}
*{{cite journal  | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
*{{cite journal  | author=Zhao H, Wang Q, Zhang H, ''et al.'' |title=UXT is a novel centrosomal protein essential for cell viability. |journal=Mol. Biol. Cell |volume=16 |issue= 12 |pages= 5857-65 |year= 2006 |pmid= 16221885 |doi= 10.1091/mbc.E05-08-0705 }}
*{{cite journal  | vauthors=Sanchez M, Galy B, Dandekar T |title=Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy |journal=J. Biol. Chem. |volume=281 |issue= 32 |pages= 22865–74 |year= 2006 |pmid= 16760464 |doi= 10.1074/jbc.M603876200 |display-authors=etal}}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | vauthors=Paulsen MT, Starks AM, Derheimer FA |title=The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancers |journal=Mol. Cancer |volume=5 |issue=  |pages= 25 |year= 2006 |pmid= 16784539 |doi= 10.1186/1476-4598-5-25 | pmc=1524803 |display-authors=etal}}
*{{cite journal  | author=Sanchez M, Galy B, Dandekar T, ''et al.'' |title=Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy. |journal=J. Biol. Chem. |volume=281 |issue= 32 |pages= 22865-74 |year= 2006 |pmid= 16760464 |doi= 10.1074/jbc.M603876200 }}
*{{cite journal  | vauthors=Esteban V, Vázquez-Novelle MD, Calvo E |title=Human Cdc14A reverses CDK1 phosphorylation of Cdc25A on serines 115 and 320 |journal=Cell Cycle |volume=5 |issue= 24 |pages= 2894–8 |year= 2007 |pmid= 17172867 |doi=  10.4161/cc.5.24.3566|display-authors=etal}}
*{{cite journal  | author=Paulsen MT, Starks AM, Derheimer FA, ''et al.'' |title=The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancers. |journal=Mol. Cancer |volume=5 |issue=  |pages= 25 |year= 2006 |pmid= 16784539 |doi= 10.1186/1476-4598-5-25 }}
*{{cite journal  | vauthors=Lanzetti L, Margaria V, Melander F |title=Regulation of the Rab5 GTPase-activating protein RN-tre by the dual specificity phosphatase Cdc14A in human cells |journal=J. Biol. Chem. |volume=282 |issue= 20 |pages= 15258–70 |year= 2007 |pmid= 17371873 |doi= 10.1074/jbc.M700914200 |display-authors=etal}}
*{{cite journal  | author=Esteban V, Vázquez-Novelle MD, Calvo E, ''et al.'' |title=Human Cdc14A reverses CDK1 phosphorylation of Cdc25A on serines 115 and 320. |journal=Cell Cycle |volume=5 |issue= 24 |pages= 2894-8 |year= 2007 |pmid= 17172867 |doi=  }}
*{{cite journal  | vauthors=Yuan K, Hu H, Guo Z |title=Phospho-regulation of HsCdc14A By Polo-like kinase 1 is essential for mitotic progression |journal=J. Biol. Chem. |volume=282 |issue= 37 |pages= 27414–23 |year= 2007 |pmid= 17623655 |doi= 10.1074/jbc.M703555200 |display-authors=etal}}
*{{cite journal  | author=Lanzetti L, Margaria V, Melander F, ''et al.'' |title=Regulation of the Rab5 GTPase-activating protein RN-tre by the dual specificity phosphatase Cdc14A in human cells. |journal=J. Biol. Chem. |volume=282 |issue= 20 |pages= 15258-70 |year= 2007 |pmid= 17371873 |doi= 10.1074/jbc.M700914200 }}
*{{cite journal  | author=Yuan K, Hu H, Guo Z, ''et al.'' |title=Phospho-regulation of HsCdc14A By Polo-like kinase 1 is essential for mitotic progression. |journal=J. Biol. Chem. |volume=282 |issue= 37 |pages= 27414-23 |year= 2007 |pmid= 17623655 |doi= 10.1074/jbc.M703555200 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Protein tyrosine phosphatases}}
{{WikiDoc Sources}}
 
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Latest revision as of 01:07, 23 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Dual specificity protein phosphatase CDC14A is an enzyme that in humans is encoded by the CDC14A gene.[1][2][3]

The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.[3]

Interactions

CDC14A has been shown to interact with P53.[4]

References

  1. ↑ Li L, Ernsting BR, Wishart MJ, Lohse DL, Dixon JE (December 1997). "A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast". J Biol Chem. 272 (47): 29403–6. doi:10.1074/jbc.272.47.29403. PMID 9367992.
  2. ↑ Wong AK, Chen Y, Lian L, Ha PC, Petersen K, Laity K, Carillo A, Emerson M, Heichman K, Gupte J, Tavtigian SV, Teng DH (September 1999). "Genomic structure, chromosomal location, and mutation analysis of the human CDC14A gene". Genomics. 59 (2): 248–51. doi:10.1006/geno.1999.5863. PMID 10409437.
  3. ↑ 3.0 3.1 "Entrez Gene: CDC14A CDC14 cell division cycle 14 homolog A (S. cerevisiae)".
  4. ↑ Li, L; Ljungman M; Dixon J E (January 2000). "The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53". J. Biol. Chem. UNITED STATES. 275 (4): 2410–4. doi:10.1074/jbc.275.4.2410. ISSN 0021-9258. PMID 10644693.

External links

Further reading



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