C8 complex: Difference between revisions
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[[File:3OJY.png|thumb|High Resolution Crystal Structure of Human Complement Component 8]] | [[File:3OJY.png|thumb|High Resolution Crystal Structure of Human Complement Component 8]] | ||
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| LocusSupplementaryData = | | LocusSupplementaryData = | ||
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'''Complement component 8''' is a protein involved in the [[complement system]]. A hereditary deficiency of C8 can result in increased susceptibility to [[Neisseria]] infections, such as meningitis and gonorrhea. | '''Complement component 8''' is a [[protein]] involved in the [[complement system]]. It is part of the [[complement membrane attack complex|membrane attack complex (MAC)]]. | ||
A [[Heredity|hereditary]] deficiency of C8 can result in increased [[Susceptible individual|susceptibility]] to [[Neisseria]] infections, such as [[meningitis]] and [[gonorrhea]]. | |||
[[Image:Formowanie MAC.svg|thumb|400px|top|Membrane attack complex. Some labels are in Polish.]] | [[Image:Formowanie MAC.svg|thumb|400px|top|Membrane attack complex. Some labels are in Polish.]] | ||
==Structure== | |||
C8 is a heterotrimer; it consists of three different subunits. These are called C8 alpha, beta and gamma chains, encoded by the [[Gene|genes]] ''C8A'', ''C8B'' and ''C8G'' respectively. | |||
==References== | ==References== | ||
Latest revision as of 07:27, 10 January 2019
| complement component 8, alpha polypeptide | |
|---|---|
| Identifiers | |
| Symbol | C8A |
| Entrez | 731 |
| HUGO | 1352 |
| OMIM | 120950 |
| RefSeq | NM_000562 |
| UniProt | P07357 |
| Other data | |
| Locus | Chr. 1 p36.2-22.1 |
| complement component 8, beta polypeptide | |
|---|---|
| Identifiers | |
| Symbol | C8B |
| Entrez | 732 |
| HUGO | 1353 |
| OMIM | 1209660 |
| RefSeq | NM_000066 |
| UniProt | P073o58 |
| Other data | |
| Locus | Chr. 1 p36.2-22.1 |
| complement component 8, gamma polypeptide | |
|---|---|
| Identifiers | |
| Symbol | C8G |
| Entrez | 733 |
| HUGO | 1354 |
| OMIM | 120930 |
| RefSeq | NM_000606 |
| UniProt | P07360 |
| Other data | |
| Locus | Chr. 9 q34.3 |
Complement component 8 is a protein involved in the complement system. It is part of the membrane attack complex (MAC).
A hereditary deficiency of C8 can result in increased susceptibility to Neisseria infections, such as meningitis and gonorrhea.
Structure
C8 is a heterotrimer; it consists of three different subunits. These are called C8 alpha, beta and gamma chains, encoded by the genes C8A, C8B and C8G respectively.
References
1.J Biol Chem. 2011 May 20;286(20):17585-92. Epub 2011 Mar 25. Figure created in Pymol
External links
- Complement+C8 at the US National Library of Medicine Medical Subject Headings (MeSH)
The crystal structure is now in the PDB, PDB ID 3OJY.
 | This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it. |