Burkitt's lymphoma classification: Difference between revisions

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{{CMG}}; {{AE}} {{AS}}
{{CMG}}; {{AE}} {{AS}}
==Overview==
==Overview==
Burkitt's lymphoma may be classified according to WHO classification into 3 clinical variants: endemic Burkitt's lymphoma, sporadic Burkitt's lymphoma, and immunodeficiency-associated Burkitt's lymphoma.
Burkitt's lymphoma may be classified according to the [[World Health Organization]] ([[WHO]]) classification into 3 clinical variants. The clinical variants are endemic Burkitt's lymphoma, sporadic Burkitt's lymphoma, and immunodeficiency-associated Burkitt's lymphoma.
==Classification==
==Classification==
===WHO Classification based on the geographic distribution and clinical presentation===
Burkitt's lymphoma may be classified according to WHO classification into 3 clinical variants:
Burkitt's lymphoma may be classified according to WHO classification into 3 clinical variants :<ref Name= Cancer.ca>Burkitt lymphoma. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/burkitt-lymphoma/?region=on Accessed on September 29, 2015</ref>
* Endemic Burkitt's lymphoma <ref name="pmid9454768">{{cite journal| author=Tao Q, Robertson KD, Manns A, Hildesheim A, Ambinder RF| title=Epstein-Barr virus (EBV) in endemic Burkitt's lymphoma: molecular analysis of primary tumor tissue. | journal=Blood | year= 1998 | volume= 91 | issue= 4 | pages= 1373-81 | pmid=9454768 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9454768  }} </ref>
* Endemic Burkitt's lymphoma  
* Sporadic Burkitt's lymphoma<ref name="pmid30042102">{{cite journal| author=Ng JY, Thompson RJ, Lam A, Nigam S| title=Sporadic Burkitt's lymphoma masquerading as an intussuscepted Meckel's diverticulum in a 9-year-old child. | journal=BMJ Case Rep | year= 2018 | volume= 2018 | issue=  | pages=  | pmid=30042102 | doi=10.1136/bcr-2018-224333 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30042102  }} </ref>
* Sporadic Burkitt's lymphoma  
* Immunodeficiency-associated Burkitt's lymphoma<ref name="pmid28506687">{{cite journal| author=Linke-Serinsöz E, Fend F, Quintanilla-Martinez L| title=Human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) related lymphomas, pathology view point. | journal=Semin Diagn Pathol | year= 2017 | volume= 34 | issue= 4 | pages= 352-363 | pmid=28506687 | doi=10.1053/j.semdp.2017.04.003 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28506687  }} </ref>
* Immunodeficiency-associated Burkitt's lymphoma
It is almost impossible to differentiate these three clinical variants based on histology (i.e. microscopic appearance) or [[immunophenotype]].


By morphology (i.e. microscopic appearance) or [[immunophenotype]], it is almost impossible to differentiate these three clinical variants. Immunodeficiency-associated Burkitt's lymphoma may demonstrate more plasmacytic appearance or more pleomorphism, but these features are not specific.
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|+ '''Classification Based on The Geographic Distribution and Clinical Presentation'''
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|+ '''WHO classification based on the geographic distribution and clinical presentation'''
! style="background: #4479BA;; color:#FFF;" | Name
! style="background: #4479BA;; color:#FFF;" | Name
! style="background: #4479BA;; color:#FFF;" | Description
! style="background: #4479BA;; color:#FFF;" | Description
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| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" | '''Endemic Burkitt's lymphoma'''  
| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" | '''Endemic Burkitt's lymphoma'''  
(African Burkitt's lymphoma)
(African Burkitt's lymphoma)
| style="padding: 5px 5px; background: #F5F5F5;" |  
| style="padding: 5px 5px; background: #F5F5F5;" |
* The most common childhood cancer in Africa
*The endemic form always presents as a jaw or [[facial bone]] [[tumor]]
* Almost always associated with [[Epstein-Barr virus]] infection
*Primary involvement of the [[abdomen]] is not very common
* Characteristically involves the jaw or other [[facial bone]], distal ileum, [[cecum]], [[ovaries]], [[kidney]], or the [[breast]]
*The primary tumor can disseminate to the extranodal sites such as the [[mesentery]], [[ovary]], [[Testicle|testis]], [[Kidney CA|kidney]], [[breast]], and [[meninges]]
*Peripheral [[Lymph node|lymph nodes]], [[mediastinum]], and [[spleen]] involvement are uncommon
*[[Bone marrow]] involvement is noted in less than 10 percent of patients at the time of initial diagnosis but is a common complication of treatment-resistant disease.
|-
|-
| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" | '''Sporadic Burkitt's lymphoma'''  
| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" | '''Sporadic Burkitt's lymphoma'''  
(Non-African or Non-endemic Burkitt's lymphoma)
(Non-African or Non-endemic Burkitt's lymphoma)
| style="padding: 5px 5px; background: #F5F5F5;" |  
| style="padding: 5px 5px; background: #F5F5F5;" |  
* The most common type of Burkitt's lymphoma in North America and European countries
* The most common type of Burkitt's lymphoma in North America and Europe
* Sometimes associated with the [[Epstein-Barr virus]], but in many cases this virus is not present
* Sometimes associated with the [[Epstein-Barr virus]], but in many cases this virus is not present
* [[Non-Hodgkin's lymphoma]], which includes Burkitt's, accounts for 30-50% of childhood lymphoma  
* [[Non-Hodgkin's lymphoma]], which includes Burkitt's, accounts for 30-50% of childhood [[lymphoma]]
* Ileo-cecal region is the common site of involvement
*This form usually has an abdominal presentation, most often with massive dissemination and [[ascites]]; the distal [[ileum]], [[stomach]] , [[cecum]] and/or mesentery, kidney, testis, ovary, breast, bone marrow, or [[Central nervous system|central nervous system (CNS)]] are involved
* Most often starts in the abdomen, but can also start in the ovaries, testicles, kidneys or other organs
*Presenting symptoms can be those that are like [[bowel obstruction]] or [[gastrointestinal bleeding]], often disguised as [[Appendicitis|acute appendicitis]] or [[intussusception]]
* Jaw is less commonly involved, comparing with the endemic variant
*Almost 25 percent of cases will have presentation of the disease in the [[jaw]] or [[facial bones]]
* Can also involve the [[pleura]] lining the lung, [[central nervous system]] (CNS) and, uncommonly, the breast
*[[Lymphadenopathy]], is generally localized
*Bone marrow and CNS involvement occurs in about 30 and 15 percent of cases, respectively, but are likely complications of recurrent or treatment resistant disease
|-
|-
| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" | '''Immunodeficiency-associated Burkitt's lymphoma'''
| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" | '''Immunodeficiency-associated Burkitt's lymphoma'''
| style="padding: 5px 5px; background: #F5F5F5;" |  
| style="padding: 5px 5px; background: #F5F5F5;" |  
* Tends to occur in people with weakened [[immune systems]], typically those with [[HIV]] infection
*The presentation of patients with immunodeficiency-related Burkitt's lymphoma is often accompanied by signs or symptoms related to the underlying immunodeficiency which can be the following:
* Incidence appears to be dropping because of [[antiretroviral therapy]]  
**[[HIV AIDS|AIDS]]
* About 30–40% of cases are associated with the Epstein-Barr virus
**[[Primary immunodeficiency|Congenital immunodeficiency]]
**Acquired immunodeficiency due to bone marrow or solid [[Organ transplant|organ transplantation]]
*Immunodeficiency-related cases frequently often involve [[lymph nodes]], [[bone marrow]], and [[CNS]]
|}
|}


==References==
==References==
{{reflist|2}}
{{reflist|2}}
{{Chromosomal abnormalities}}
{{Chromosomal abnormalities}}
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[[Category:Hematology]]
[[Category:Hematology]]
[[Category:Types of cancer]]
[[Category:Types of cancer]]
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Hematology]]
[[Category:Immunology]]

Latest revision as of 04:44, 18 January 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Burkitt's lymphoma may be classified according to the World Health Organization (WHO) classification into 3 clinical variants. The clinical variants are endemic Burkitt's lymphoma, sporadic Burkitt's lymphoma, and immunodeficiency-associated Burkitt's lymphoma.

Classification

Burkitt's lymphoma may be classified according to WHO classification into 3 clinical variants:

  • Endemic Burkitt's lymphoma [1]
  • Sporadic Burkitt's lymphoma[2]
  • Immunodeficiency-associated Burkitt's lymphoma[3]

It is almost impossible to differentiate these three clinical variants based on histology (i.e. microscopic appearance) or immunophenotype.

Classification Based on The Geographic Distribution and Clinical Presentation
Name Description
Endemic Burkitt's lymphoma

(African Burkitt's lymphoma)

Sporadic Burkitt's lymphoma

(Non-African or Non-endemic Burkitt's lymphoma)

Immunodeficiency-associated Burkitt's lymphoma
  • The presentation of patients with immunodeficiency-related Burkitt's lymphoma is often accompanied by signs or symptoms related to the underlying immunodeficiency which can be the following:
  • Immunodeficiency-related cases frequently often involve lymph nodes, bone marrow, and CNS

References

  1. Tao Q, Robertson KD, Manns A, Hildesheim A, Ambinder RF (1998). "Epstein-Barr virus (EBV) in endemic Burkitt's lymphoma: molecular analysis of primary tumor tissue". Blood. 91 (4): 1373–81. PMID 9454768.
  2. Ng JY, Thompson RJ, Lam A, Nigam S (2018). "Sporadic Burkitt's lymphoma masquerading as an intussuscepted Meckel's diverticulum in a 9-year-old child". BMJ Case Rep. 2018. doi:10.1136/bcr-2018-224333. PMID 30042102.
  3. Linke-Serinsöz E, Fend F, Quintanilla-Martinez L (2017). "Human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) related lymphomas, pathology view point". Semin Diagn Pathol. 34 (4): 352–363. doi:10.1053/j.semdp.2017.04.003. PMID 28506687.

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