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==Causes== | ==Causes== | ||
The following are the causes of Alzheimer's dementia (AD): | The following are the causes of Alzheimer's dementia (AD):<ref name="urlAlzheimer Disease Overview - GeneReviews® - NCBI Bookshelf">{{cite web |url=https://www.ncbi.nlm.nih.gov/books/NBK1161/ |title=Alzheimer Disease Overview - GeneReviews® - NCBI Bookshelf |format= |work= |accessdate=}}</ref><ref name="pmid16966510">{{cite journal |vauthors=Brickell KL, Steinbart EJ, Rumbaugh M, Payami H, Schellenberg GD, Van Deerlin V, Yuan W, Bird TD |title=Early-onset Alzheimer disease in families with late-onset Alzheimer disease: a potential important subtype of familial Alzheimer disease |journal=Arch. Neurol. |volume=63 |issue=9 |pages=1307–11 |year=2006 |pmid=16966510 |doi=10.1001/archneur.63.9.1307 |url=}}</ref><ref name="pmid10441572">{{cite journal |vauthors=Campion D, Dumanchin C, Hannequin D, Dubois B, Belliard S, Puel M, Thomas-Anterion C, Michon A, Martin C, Charbonnier F, Raux G, Camuzat A, Penet C, Mesnage V, Martinez M, Clerget-Darpoux F, Brice A, Frebourg T |title=Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum |journal=Am. J. Hum. Genet. |volume=65 |issue=3 |pages=664–70 |year=1999 |pmid=10441572 |pmc=1377972 |doi=10.1086/302553 |url=}}</ref><ref name="pmid11216203">{{cite journal |vauthors=Munoz DG, Feldman H |title=Causes of Alzheimer's disease |journal=CMAJ |volume=162 |issue=1 |pages=65–72 |year=2000 |pmid=11216203 |pmc=1232234 |doi= |url=}}</ref><ref name="pmid9848086">{{cite journal |vauthors=Hölscher C |title=Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis |journal=Neurobiol. Dis. |volume=5 |issue=3 |pages=129–41 |year=1998 |pmid=9848086 |doi=10.1006/nbdi.1998.0193 |url=}}</ref> | ||
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|'''Cause''' | |'''Cause''' | ||
Revision as of 22:17, 17 September 2017
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Causes
The following are the causes of Alzheimer's dementia (AD):[1][2][3][4][5]
| Cause | Specific characteristics | Percentage of cases |
| Chromosomal (Down syndrome) |
|
<1% |
| All familial | ~25% | |
|
|
15%-25% |
|
|
<2% |
| Unknown (includes genetic/environment interactions) |
|
~75% |
References
- ↑ "Alzheimer Disease Overview - GeneReviews® - NCBI Bookshelf".
- ↑ Brickell KL, Steinbart EJ, Rumbaugh M, Payami H, Schellenberg GD, Van Deerlin V, Yuan W, Bird TD (2006). "Early-onset Alzheimer disease in families with late-onset Alzheimer disease: a potential important subtype of familial Alzheimer disease". Arch. Neurol. 63 (9): 1307–11. doi:10.1001/archneur.63.9.1307. PMID 16966510.
- ↑ Campion D, Dumanchin C, Hannequin D, Dubois B, Belliard S, Puel M, Thomas-Anterion C, Michon A, Martin C, Charbonnier F, Raux G, Camuzat A, Penet C, Mesnage V, Martinez M, Clerget-Darpoux F, Brice A, Frebourg T (1999). "Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum". Am. J. Hum. Genet. 65 (3): 664–70. doi:10.1086/302553. PMC 1377972. PMID 10441572.
- ↑ Munoz DG, Feldman H (2000). "Causes of Alzheimer's disease". CMAJ. 162 (1): 65–72. PMC 1232234. PMID 11216203.
- ↑ Hölscher C (1998). "Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis". Neurobiol. Dis. 5 (3): 129–41. doi:10.1006/nbdi.1998.0193. PMID 9848086.