Acute promyelocytic leukemia laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]

Overview

The laboratory abnormalities in acute promyelocytic leukemia can be broadly divided into abnormalities of the complete blood count and abnormalities of the coagulation system. The complete blood count usually shows anemia, thrombocytopenia, leukopenia, and elevated blast count. The coagulation profile usually shows elevated prothrombin time, elevated partial thromboplastin time, elevated thrombin time, elevated reptilase time, and low fibrinogen. This combination of coagulation parameters accounts for high hemorrhagic risk in patients with acute promyelocytic leukemia.

Laboratory Findings

Abnormalities of the complete blood count

Abnormalities of coagulation parameters

References

  1. Brodsky RA, Jones RJ (October 2004). "Riddle: what do aplastic anemia, acute promyelocytic leukemia, and chronic myeloid leukemia have in common?". Leukemia. 18 (10): 1740–2. doi:10.1038/sj.leu.2403487. PMID 15356647.
  2. Lee HJ, Park HJ, Kim HW, Park SG (December 2013). "Comparison of laboratory characteristics between acute promyelocytic leukemia and other subtypes of acute myeloid leukemia with disseminated intravascular coagulation". Blood Res. 48 (4): 250–3. doi:10.5045/br.2013.48.4.250. PMC 3894382. PMID 24466548.
  3. Jillella AP, Arellano ML, Heffner LT, Gaddh M, Langston AA, Khoury HJ, Mangoankar A, Kota VK (September 2017). "Managing acute promyelocytic leukemia in patients belonging to the Jehovah's Witness congregation". Hematol Rep. 9 (3): 7083. doi:10.4081/hr.2017.7083. PMC 5641824. PMID 29071052.
  4. 4.0 4.1 4.2 4.3 Franchini M, Lippi G, Manzato F (2006). "Recent acquisitions in the pathophysiology, diagnosis and treatment of disseminated intravascular coagulation". Thromb J. 4: 4. doi:10.1186/1477-9560-4-4. PMC 1402263. PMID 16504043.
  5. Bassi SC, Rego EM (2012). "Molecular basis for the diagnosis and treatment of acute promyelocytic leukemia". Rev Bras Hematol Hemoter. 34 (2): 134–9. doi:10.5581/1516-8484.20120033. PMC 3459394. PMID 23049403.

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