Acromegaly causes: Difference between revisions
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{{CMG}}; {{AE}} {{AEL}} | {{CMG}}; {{AE}} {{AEL}} | ||
==Overview== | ==Overview== | ||
Common causes of acromegaly include pituitary adenoma, acidophil stem cell adenomas, pleurihormonal adenoma. Less common causes of acromegaly include GHRH secreting tumors as hypothalamic tumors, small cell lung cancer, adrenal adenoma, and pheochromocytoma. Other causes include GH secreting tumors as lymphoma and pancreatic islet cell tumor. | Common causes of acromegaly include [[pituitary adenoma]], acidophil [[stem cell]] adenomas, pleurihormonal adenoma. Less common causes of acromegaly include GHRH secreting tumors as hypothalamic tumors, small cell lung cancer, adrenal adenoma, and pheochromocytoma. Other causes include GH secreting tumors as lymphoma and pancreatic islet cell tumor. | ||
==Causes== | ==Causes== | ||
Revision as of 14:16, 14 August 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]
Overview
Common causes of acromegaly include pituitary adenoma, acidophil stem cell adenomas, pleurihormonal adenoma. Less common causes of acromegaly include GHRH secreting tumors as hypothalamic tumors, small cell lung cancer, adrenal adenoma, and pheochromocytoma. Other causes include GH secreting tumors as lymphoma and pancreatic islet cell tumor.
Causes
Common Causes
Acromegaly may be caused by:
- Pituitary adenoma:[1]
- The pituitary adenoma is a benign tumor in the pituitary gland and it resembles the most common cause of acromegaly.
- The pituitary adenoma is responsible for excessive secretion of the growth hormone and the insulin like growth factor-1.
- Some of the pituitary adenomas have a slow progression and may not be noticed for years.
- Other types of pituitary adenoma causing acromegaly:
- Mixed growth hormone and prolactin cell adenomas
- Acidophil stem cell adenomas
- Mammosomatotroph cell adenomas
- Pleurihormonal adenomas
Less Common Causes
Less common causes of acromegaly include:[1]
- Hypothalamic tumors which secrete Growth Hormone Releasing Hormone (GHRH).
- Ectopic tumor secretion of GHRH. These tumors include the following:
- Small cell lung cancer
- Adrenal adenoma
- Pheochromocytoma
- Thyroid carcinoma
- Ectopic tumor secretion of GH. These tumors include the following:
- Lymphoma
- Pancreatic islet cell tumor
Genetic Causes
- Acromegaly is caused by a mutation in the guanine nucleotide stimulatory protein gene which is responsible for pituitary adenomas.[2]
Causes by Organ System
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | No underlying causes |
| Ear Nose Throat | No underlying causes |
| Endocrine | Pituitary adenoma, Adrenal adenoma, Pancreatic islet cell tumor, Pheochromocytoma, Thyroid carcinoma, |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | No underlying causes |
| Hematologic | No underlying causes |
| Iatrogenic | No underlying causes |
| Infectious Disease | No underlying causes |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | No underlying causes |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | Small cell lung cancer |
| Renal/Electrolyte | No underlying causes |
| Rheumatology/Immunology/Allergy | No underlying causes |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
Causes in Alphabetical Order
List the causes of the disease in alphabetical order.
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3References
- ↑ 1.0 1.1 Melmed S, Braunstein GD, Horvath E, Ezrin C, Kovacs K (1983). "Pathophysiology of acromegaly". Endocr Rev. 4 (3): 271–90. doi:10.1210/edrv-4-3-271. PMID 6354702.
- ↑ Landis CA, Masters SB, Spada A, Pace AM, Bourne HR, Vallar L (1989). "GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours". Nature. 340 (6236): 692–6. doi:10.1038/340692a0. PMID 2549426.