AM-855

AM-855
	File:AM-855.png
Identifiers
	IUPAC name (4aR,12bR)-8-hexyl-2,5,5-trimethyl-1,4,4a,8,9,10,11,12b-octahydronaphtho[3,2-c]isochromen-12-ol;
PubChem CID	10091328;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C26H38O2
Molar mass	382.577 g/mol
3D model (JSmol)	Interactive image;
	SMILES Oc1c4C2CC(C)=CCC2C(C)(C)Oc4cc3c1CCCC3CCCCCC;

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AM-855 is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8THC with a conformationally restricted side chain which has been bound into a fourth ring fused to the aromatic A-ring of the cannabinoid skeleton. AM-855 is an agonist at both CB₁ and CB₂ with moderate selectivity for CB₁, with a Ki of 22.3nM at CB₁ and 58.6nM at CB₂.^[1]

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References

↑ Khanolkar AD, Lu D, Fan P, Tian X, Makriyannis A. Novel conformationally restricted tetracyclic analogs of delta8-tetrahydrocannabinol. Bioorganic and Medicinal Chemistry Letters. 1999 Aug 2;9(15):2119-24. PMID 10465529

Template:WikiDoc Sources

[1] Khanolkar AD, Lu D, Fan P, Tian X, Makriyannis A. Novel conformationally restricted tetracyclic analogs of delta8-tetrahydrocannabinol. Bioorganic and Medicinal Chemistry Letters. 1999 Aug 2;9(15):2119-24. PMID 10465529

[1]

Identifiers
File:AM-855.png
IUPAC name (4aR,12bR)-8-hexyl-2,5,5-trimethyl-1,4,4a,8,9,10,11,12b-octahydronaphtho[3,2-c]isochromen-12-ol
PubChem CID	10091328
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₆H₃₈O₂
Molar mass	382.577 g/mol
3D model (JSmol)	Interactive image
SMILES Oc1c4C2CC(C)=CCC2C(C)(C)Oc4cc3c1CCCC3CCCCCC

AM-855

References

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