Hemophilia epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
The prevalence of hemophilia is estimated to be 20,000 cases in the United States annually. The age-adjusted prevalence of hemophilia in six US states (Oklahoma, Massachusetts, Colorado, Georgia, Louisiana, and New York) in 1994 was 13.4 cases per 100, 000 males. The incidence of hemophilia is estimated to be 1 in 5,000 male births for hemophilia A and 1 in 30,000 births for hemophilia B.
Epidemiology and Demographics
Incidence
- The mean incidence of hemophilia from 1982-91 was 1 in 5,032 live male births.[1]
- The incidence of congenital hemophilia A is 1 in 5000 boys/men.[1][2]
- The incidence of congenital hemophilia B is about 1 in 30,000 boys/men.[1]
- 400 hemophilic babies are born every year in the United States.[1][3][4]
Prevalence
- The age-adjusted prevalence of hemophilia in six US states (Oklahoma, Massachusetts, Colorado, Georgia, Louisiana, and New York) in 1994 was 13.4 cases per 100, 000 males.[1]
- The prevalence of hemophilia in Swedish population was 13.7 per 100, 000 males in 1980.[1][5]
- The prevalence of hemophilia in other countries identified through contact with specialized hemophilia treatment centers range from 9.7 to 20.5 per 100, 000 males.[1][6][7][8][9][10]
Race
Hemophilia affects people from all racial and ethnic groups. However hemophilia C predominantly occurs in Jews of Ashkenazi descent.
Gender
Hemophilia A and B occurs more often in males and less often in females. Hemophilia C is mild form of hemophilia affecting both sexes equally.
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Soucie JM, Evatt B, Jackson D (December 1998). "Occurrence of hemophilia in the United States. The Hemophilia Surveillance System Project Investigators". Am. J. Hematol. 59 (4): 288–94. PMID 9840909.
- ↑ https://www.nhlbi.nih.gov/health-topics/hemophilia
- ↑ https://www.nhlbi.nih.gov/health-topics/hemophilia
- ↑ "CDC Hemophilia Epidemiology and demographics".
- ↑ Larsson SA, Nilsson IM, Blombäck M (1982). "Current status of Swedish hemophiliacs. I. A demographic survey". Acta Med Scand. 212 (4): 195–200. PMID 7148514.
- ↑ Rosendaal FR, Varekamp I, Smit C, Bröcker-Vriends AH, van Dijck H, Vandenbroucke JP, Hermans J, Suurmeijer TP, Briët E (January 1989). "Mortality and causes of death in Dutch haemophiliacs, 1973-86". Br. J. Haematol. 71 (1): 71–6. PMID 2917132.
- ↑ Walker I (1991). "Survey of the Canadian hemophilia population". Can J Public Health. 82 (2): 127–9. PMID 2049704.
- ↑ Rizza CR, Spooner RJ (March 1983). "Treatment of haemophilia and related disorders in Britain and Northern Ireland during 1976-80: report on behalf of the directors of haemophilia centres in the United Kingdom". Br Med J (Clin Res Ed). 286 (6369): 929–33. PMID 6403138.
- ↑ Koumbarelis E, Rosendaal FR, Gialeraki A, Karafoulidou A, Noteboom WM, Loizou C, Panayotopoulou C, Markakis C, Mandalaki T (December 1994). "Epidemiology of haemophilia in Greece: an overview". Thromb. Haemost. 72 (6): 808–13. PMID 7740446.
- ↑ Ghirardini A, Schinaia N, Chiarotti F, De Biasi R, Rodeghiero F, Binkin N (November 1994). "Epidemiology of hemophilia and of HIV infection in Italy. GICC. Gruppo Italiano Coagulopatie Congenite". J Clin Epidemiol. 47 (11): 1297–306. PMID 7722566.