Tropheryma whipplei

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Tropheryma whipplei
Scientific classification
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Subclass: Actinobacteridae
Order: Actinomycetales
Genus: Tropheryma
Species: T. whipplei
Binomial name
Tropheryma whipplei
La Scola et al 2001

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Tropheryma whipplei is a bacterium and the causative organism of Whipple's disease.[1] While T. whipplei is categorized with the Gram-positive Actinobacteria, the organism is commonly found to be Gram-negative or Gram-indeterminate when stained in the laboratory.[1] Whipple himself probably observed the organisms as rod-shaped structures with silver stain in his original case,[2] but no name was given to the organism until 1991 when the name Tropheryma whippelii was proposed after sections of the bacterial genome were sequenced.[3] The name was changed to Tropheryma whipplei in 2001 (correcting the spelling of Whipple's name) after deposition in bacterial collections.[1]

Pathogenesis

See Whipple's disease

References

  1. 1.0 1.1 1.2 {La Scola B, Fenollar F, Fournier P, Altwegg M, Mallet M, Raoult D (2001). "Description of Tropheryma whipplei gen. nov., sp. nov., the Whipple's disease bacillus". Int J Syst Evol Microbiol. 51 (Pt 4): 1471–9. PMID 11491348.
  2. Whipple GH. (1907). "A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and msenteric lymphatic tissues". Johns Hopkins Hosp Bull. 18: 382&ndash, 91.
  3. Relman D, Schmidt T, MacDermott R, Falkow S (1992). "Identification of the uncultured bacillus of Whipple's disease". N Engl J Med. 327 (5): 293–301. PMID 1377787.

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