Hemophilia laboratory findings: Difference between revisions

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==Overview==
==Overview==
Laboratory findings consistent with the diagnosis of hemophilia include unaffected [[prothrombin time]], prolonged [[partial thromboplastin time]], unaffected [[bleeding time]] and unaffected [[platelet count]].
Laboratory findings consistent with the diagnosis of hemophilia include normal [[prothrombin time (PT)]], prolonged [[activated partial thromboplastin time (aPTT)]], normal [[bleeding time (BT)]], and normal [[platelet count]].
==Laboratory Findings==
==Laboratory Findings==
[[Screening]] tests are blood tests that show if the blood is clotting properly. Types of screening tests:
Laboratory findings consistent with the diagnosis of hemophilia include:
===Complete Blood Count (CBC)===
*Normal prothrombin time (PT)
This common test measures the amount of hemoglobin (the red pigment inside [[red blood cells]] that carries oxygen), the size and number of red blood cells and numbers of different types of [[white blood cells]] and [[platelets]] found in blood. The [[CBC]] is normal in people with hemophilia. However, if a person with hemophilia has unusually heavy bleeding or bleeds for a long time, the [[hemoglobin]] and the [[red blood cell]] count can be low.
*Normal platelet count  
===Activated Partial Thromboplastin Time (APTT) Test===
*Normal bleeding time
This test measures how long it takes for blood to clot. It measures the clotting ability of factors VIII (8), IX (9), XI (11), and XII (12). If any of these clotting factors are too low, it takes longer than normal for the blood to clot. The results of this test will show a longer clotting time among people with hemophilia A or B.
*Elevated activated partial thromboplastin time (aPTT)
===Prothrombin Time (PT) Test===
This test also measures the time it takes for blood to clot. It measures primarily the clotting ability of factors I (1), II (2), V (5), VII (7), and X (10). If any of these factors are too low, it takes longer than normal for the blood to clot. The results of this test will be normal among most people with hemophilia A and B.
===Fibrinogen Test===
This test also helps doctors assess a patient’s ability to form a blood clot. This test is ordered either along with other blood clotting tests or when a patient has an abnormal [[PT]] or [[APTT]] test result, or both. [[Fibrinogen]] is another name for [[clotting factor]] I (1).
===Clotting Factor Tests===
[[Clotting factor]] tests, also called factor assays, are required to diagnose a bleeding disorder. This blood test shows the type of hemophilia and the severity. It is important to know the type and severity in order to create the best treatment plan.
 
{| style="border: 0px; font-size: 90%; margin: 3px; width: 500px;" align=center
|valign=top|
|+
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Condition}}
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Prothrombin time}}
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Partial Thromboplastin Time}}
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Bleeding Time}}
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Platelet Count}}
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Hemophilia A or B
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Von Willebrand Disease
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged or Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Thrombocytopenia
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Decreased
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Vitamin K deficiency or Warfarin
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Normal or mildly prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Disseminated Intravascular Coagulation
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Decreased
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Liver failure, early
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Aspirin
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Liver failure, end-stage
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Pronlonged
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Decreased
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Uremia
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Congenital afibrinogenemia
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Factor V deficiency
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Factor X deficiency as seen in amyloid purpura
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Glanzmann's thrombasthenia
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Bernard-Soulier syndrome
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Decreased
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Factor XII deficiency
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Decreased or unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | C1INH deficiency
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Shortened
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #F5F5F5;" colspan=5| <small>Adapted from Wikipedia hemophilia Laboratory Finding> {{cite web|  url=https://en.wikipedia.org/wiki/Haemophilia| title=Wikipedia Hemophilia Laboratory Finding  }}</small>
|}
 
==References==
==References==


Revision as of 21:08, 21 January 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

Laboratory findings consistent with the diagnosis of hemophilia include normal prothrombin time (PT), prolonged activated partial thromboplastin time (aPTT), normal bleeding time (BT), and normal platelet count.

Laboratory Findings

Laboratory findings consistent with the diagnosis of hemophilia include:

  • Normal prothrombin time (PT)
  • Normal platelet count
  • Normal bleeding time
  • Elevated activated partial thromboplastin time (aPTT)

References

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