VIPoma history and symptoms: Difference between revisions
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===Symptoms=== | ===Common Symptoms=== | ||
Symptoms of VIPoma usually arise when tumor reaches certain size. Most tumors are > 2cm and metastatic by the time symptoms arise. | Symptoms of VIPoma usually arise when tumor reaches certain size. Most tumors are > 2cm and metastatic by the time symptoms arise. Common symptoms may include any of the following:<ref name="sss">VIPoma. U.S. National Library of Medicine. Accessed on October 23, 2015. https://www.nlm.nih.gov/medlineplus/ency/article/000228.htm </ref><ref name="pmid16357627" /><ref name="pmid17510774">{{cite journal| author=Ghaferi AA, Chojnacki KA, Long WD, Cameron JL, Yeo CJ| title=Pancreatic VIPomas: subject review and one institutional experience. | journal=J Gastrointest Surg | year= 2008 | volume= 12 | issue= 2 | pages= 382-93 | pmid=17510774 | doi=10.1007/s11605-007-0177-0 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17510774 }} </ref><ref name="pmid235829162" /> | ||
*Watery [[diarrhea]] like cholera and volume ranges from 750ml to more than 3 liters. Secretory diarrhea persists even on fasting for 48 hours and is odorless. The stool appears like dilute tea in color, is blood and mucus free.<ref>Vasoactive Intestinal Peptide Tumor (VIPoma) | *Watery [[diarrhea]] like cholera and volume ranges from 750ml to more than 3 liters. Secretory diarrhea persists even on fasting for 48 hours and is odorless. The stool appears like dilute tea in color, is blood and mucus free.<ref>Vasoactive Intestinal Peptide Tumor (VIPoma) | ||
Aaron Vinik, MD, PhD, FCP, MACP, FACE | Aaron Vinik, MD, PhD, FCP, MACP, FACE | ||
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*[[Lethargy]] | *[[Lethargy]] | ||
*[[Muscle weakness]] | *[[Muscle weakness]] | ||
*[[Weight loss]] | *[[Weight loss]] | ||
*[[Numbness]] caused due to [[hypokalaemia]] | *[[Numbness]] caused due to [[hypokalaemia]] | ||
*[[Flushing]] | *[[Flushing]] | ||
===Less Common Symptoms=== | |||
*Crampy [[abdominal pain]] | |||
*[[Nausea]] | |||
*[[Vomiting]] | |||
==References== | ==References== | ||
Revision as of 14:59, 12 January 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Madhu Sigdel M.B.B.S.[2]Parminder Dhingra, M.D. [3]
Overview
The hallmark of VIPoma is watery diarrhea. A positive history of abdominal pain, weight loss, numbness, and weakness is suggestive of VIPoma.[1][2][3][4]
History and Symptoms
The hallmark of VIPoma is watery diarrhea. A positive history of abdominal pain, weight loss, numbness, and weakness is suggestive of VIPoma.[1][2][3][4]
History
Patients with VIPoma may have a positive history of:
- Watery diarrhea
- Abdominal pain
- Weakness
Common Symptoms
Symptoms of VIPoma usually arise when tumor reaches certain size. Most tumors are > 2cm and metastatic by the time symptoms arise. Common symptoms may include any of the following:[1][2][3][4]
- Watery diarrhea like cholera and volume ranges from 750ml to more than 3 liters. Secretory diarrhea persists even on fasting for 48 hours and is odorless. The stool appears like dilute tea in color, is blood and mucus free.[5]
- Dehydration (thirst, dry skin, dry mouth, tiredness, headaches, and dizziness)
- Lethargy
- Muscle weakness
- Weight loss
- Numbness caused due to hypokalaemia
- Flushing
Less Common Symptoms
- Crampy abdominal pain
- Nausea
- Vomiting
References
- ↑ 1.0 1.1 VIPoma. U.S. National Library of Medicine. Accessed on October 23, 2015. https://www.nlm.nih.gov/medlineplus/ency/article/000228.htm
- ↑ 2.0 2.1 Remme CA, de Groot GH, Schrijver G (2006). "Diagnosis and treatment of VIPoma in a female patient". Eur J Gastroenterol Hepatol. 18 (1): 93–9. PMID 16357627.
- ↑ 3.0 3.1 Ghaferi AA, Chojnacki KA, Long WD, Cameron JL, Yeo CJ (2008). "Pancreatic VIPomas: subject review and one institutional experience". J Gastrointest Surg. 12 (2): 382–93. doi:10.1007/s11605-007-0177-0. PMID 17510774.
- ↑ 4.0 4.1 Ito T, Igarashi H, Jensen RT (2012). "Pancreatic neuroendocrine tumors: clinical features, diagnosis and medical treatment: advances". Best Pract Res Clin Gastroenterol. 26 (6): 737–53. doi:10.1016/j.bpg.2012.12.003. PMC 3627221. PMID 23582916.
- ↑ Vasoactive Intestinal Peptide Tumor (VIPoma) Aaron Vinik, MD, PhD, FCP, MACP, FACE Murray Waitzer Endowed Chair for Diabetes Research, Professor of Medicine/Pathology/Neurobiology, Director of Research and Neuroendocrine Unit, Division of Endocrine and Metabolic Disorders, Eastern Virginia Medical School, Norfolk, VA