VIPoma natural history, complications and prognosis

	VIPoma Microchapters
Home
Patient Information
Overview
Historical Perspective
Pathophysiology
Causes
Differentiating VIPoma from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X Ray
CT
MRI
Echocardiography or Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Interventions
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
VIPoma natural history, complications and prognosis On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of VIPoma natural history, complications and prognosis All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on VIPoma natural history, complications and prognosis
CDC on VIPoma natural history, complications and prognosis
VIPoma natural history, complications and prognosis in the news
Blogs on VIPoma natural history, complications and prognosis
Directions to Hospitals Treating VIPoma
Risk calculators and risk factors for VIPoma natural history, complications and prognosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Madhu Sigdel M.B.B.S.[2]Parminder Dhingra, M.D. [3] Homa Najafi, M.D.[4]

Overview

If left untreated, patients with VIPoma may progress to develop watery diarrhea, abdominal pain, bloating, nausea, vomiting, skin rash, backache, flushing, and lethargy. Common complications of VIPoma include metastasis, cardiac arrest from low blood potassium level, and dehydration. The presence of metastasis is associated with a particularly poor prognosis among patients with VIPoma, with a 5 year survival rate of 60%.

If left untreated, patients with VIPoma may progress to develop watery diarrhea, abdominal pain, bloating, nausea, vomiting, skin rash, backache, flushing, and lethargy.^[1]
VIPoma have a very slow growth rate compared to the most malignant tumors.

Common complications of VIPoma include:^[2]^[3]

Surgery can usually cure VIPomas. However, in one-third to one-half of patients, the tumor has spread by the time of diagnosis and cannot be cured.^[4]
The 5-year survival for patients with localized VIPoma is 94% whereas metastatic pancreatic VIPomas is 60%, respectively.

↑ Natanzi, Naveed; Amini, Mazyar; Yamini, David; Nielsen, Shawn; Ram, Ramin (2009). "Vasoactive Intestinal Peptide Tumor". Scholarly Research Exchange. 2009: 1–7. doi:10.3814/2009/938325. ISSN 1687-8299.
↑ J. V. VERNER & A. B. MORRISON (1958). "Islet cell tumor and a syndrome of refractory watery diarrhea and hypokalemia". The American journal of medicine. 25 (3): 374–380. doi:10.1016/0002-9343(58)90075-5. PMID 13571250. Unknown parameter |month= ignored (help)
↑ A. Ayub, M. Zafar, A. Abdulkareem, M. A. Ali, T. Lingawi & A. Harbi (1993). "Primary hepatic vipoma". The American journal of gastroenterology. 88 (6): 958–961. PMID 8389095. Unknown parameter |month= ignored (help)
↑ Nilubol N, Freedman EM, Quezado MM, Patel D, Kebebew E (2016). "Pancreatic Neuroendocrine Tumor Secreting Vasoactive Intestinal Peptide and Dopamine With Pulmonary Emboli: A Case Report". J Clin Endocrinol Metab. 101 (10): 3564–3567. doi:10.1210/jc.2016-2051. PMC 5052354. PMID 27583474.